Objective To investigate the expression and clinical significance of serum PTX3 in HCC patients. Methods We selected 78 HCC patients as the liver cancer group, and 78 cases of healthy subjects as the healthy control group. The PTX3 levels were detected and compared between the two groups. The differences of PTX3 levels in patients with different pathological characteristics were analyzed. ROC curve was used to analyze the auxiliary diagnostic value of serum PTX3 in HCC. Results PTX3 level in HCC patients was higher than that in healthy control group (P < 0.05). PTX3 level in stage Ⅰ group was higher than those in the stage Ⅱ group and Ⅲ group (P < 0.05). PTX3 level in patients with tumor ≥5cm was significantly lower than that with tumor diameter < 5cm (P < 0.05). In addition, PTX3 level in patients with HBV infection was significantly higher than that without HBV infection (P < 0.05). The AUC was 0.938. Conclusion The serum PTX3 level is significantly increased in patients with HCC. It has auxiliary diagnostic value for HCC.

Objective To evaluate the application value of high resolution MRI fat suppression T2WI combined with DWI in anal fistula and its activity. Methods We analyzed the clinical data and MRI findings of 59 patients who received high resolution MRI from January 2016 to November 2017. According to the clinical and surgical results,anal fistulas were divided into positive inflammatory activity(PIA)and negative inflammatory activity(NIA). ADC values of anal fistula were measured and the optimal cut-off of ADC values were calculated. Results 59 patients with 71 anal fistulas and 62 internal openings confirmed by surgical results.ADC values were differenct between PIA and NIA anal fistulas(P = 0.001) and the optimal cut-off of ADC value were 1.214. The sensitivity of high resolution MRI fat suppression T2WI,DWI and T2WI combined with DWI for detecting anal fistula and internal opening were 80.28%(57/71),83.10%(59/71),95.77%(68/71) and 82.26%(51/62), 83.87%(52/62),96.77%(60/62),respectively. Conclusion MRI-DWI is very important for evaluating the activities of anal fistula and thigh resolution MRI fat suppression T2WI combined with DWI has the highest sensitivity for detecting anal fistula and internal opening.

【Objective】 To analyze the sensory integration characteristics of 4- to 5-year-old preschool children while maintaining static balance, in order to provide reference for promoting the development of motor development. 【Methods】 A total of 128 preschool children were randomly selected in this study from a public kindergarten in Suzhou. Wearable sensor were worn at the center of mass(COM) position for four tests: T1 standing with eyes open, T2 standing with eyes closed, T3 standing with eyes open on a sponge pad, and T4 standing with eyes closed on a sponge pad. The angular velocity modulus(ω) of COM shaking was extracted, the Romberg quotient(RQ), vestibular Romberg quotient(VRQ), and the rate of increase in body stability when integrating different sensations were calculated. The contribution weights and sensory integration characteristics of visual, proprioceptive, and vestibular sensations to static balance were analyzed. Independent sample t-test was used to analyze the differences between different gender and age groups. 【Results】 The RQ was 1.20, and the VRQ was 1.58. The contribution rates of visual, proprioceptive, and vestibular senses to body balance were approximately 9.28%, 28.19% and 62.53%, respectively. The difference in the rate of increase in body stability between integrated vision and integrated proprioception with normal vestibular perception was statistically significant(P<0.001, Cohen′s d=-1.14),while the difference in the rate of increase in body stability between integrated proprioception and vestibular perception with normal vestibular perception and integrated vision with normal proprioception was statistically significant(P<0.001, Cohen′s d=2.30). The difference in the rate of increased body stability between the sum of vestibular and proprioceptive integration and the simultaneous integration of visual and proprioceptive integration was statistically significant(P<0.001, Cohen′s d=-0.86). The gender differences in RQ, VRQ, and the rate of increased body stability when integrating different sensations(P>0.05) and the difference in half year old age was not statistically significant(P>0.05). 【Conclusions】 When preschool children aged 4 - 5 maintain static balance, the contribution of vestibular integration proprioception to body stability is greater than that of vestibular integrate vision. The contribution of vestibular and visual integrate proprioception to body stability is greater than that of vestibular and proprioception integrate vision. The sensory integration characteristics between boys and girls, as well as half year old children, are basically the same.