Objective To explore the causes of misdiagnose of ectopic pregnancy by retrospective analysis in our hospital cases,in order to increase the diagnose and curative level in ectopic pregnancy.Methods Clinical data of the misdiagnosis of 96 cases from the 357 patients of ectopic pregnancy in our hospital from year 1993 to 2002,including materials of histories ,symptoms signs and laboratory examinations were retrospectively analyzed.Results The misdiagnosis rate of ectopic pregnancy in our hospital was 26 9%, most of them were treated as early pregnancies, threatened abortions etc. The causes of misdiagnosis were neglectful of asking essential history, no overall physical examination and misleading by the laboratory results.Conclusions The effectively preventive measures against misdiagnosing of ectopic pregnancy were strengthen vigilance of ectopic pregnancy,familiar with the knowledge of atypical ectopic pregnancy and the essential examinations on gravida.

Bone growth factors play an important role in the process of bone metabolism and perform a variety of physio -logical functions such as regulating bone growth , differentiation and remodeling .Meanwhile , these cytokines are associated with orthopedic disorder and therapy .The curative effect of the overturned sartorius iliac flap in repair of acetabular defect in developmental dysplasia of the hip proves to be good , but mechanism between the overturned flap and the surrounding bone tissue is unclear .This review briefly summarizes the functions and applications of several major cytokines in bone for -mation and remodeling , which may provide new ideas and methods for illuminating the mechanism of these cytokines during the repair of the acetabular defect .

Objective To investigate the influence of pravastatin on serum matrix metalloproteinases-1(MMP-1), MMP-9 and its role in prevention of restenosis following coronary intervention. Methods Totally 62 patients after percutaneous coronary intervention (PCI) were randomly assigned to receive 10 mg/d pravastatin in 24-48 h after PCI for 6 months (n=32) or no therapy (n=30) as control. The blood samples of all patients were examined at admission and 7, 21 d after administration of pravastatin. All patients received follow-up and coronary checking within 6 months. Results TIMI 3 flow was achieved in all cases and residual stenosis was less than 20%. No severe complications were found. ①The use of pravastatin after PCI could significantly reduce serum levels of MMP-1 and MMP-9 as compared with control group (P

Objective To investigate sexual life associated with hysterectomy of young women and its related factors.Methods Data from 199 patients with hysterectomy were collected.Statistical analysis was performed between the postoperative recovery condition among them,including daily life and sex life.Results There was significant difference on sexual life quality of the patients by hysterectomy among patient age,occupation,education,postoperative time,disease and complication (P ＜ 0.05).The age of 41-50 years and 51-60 years old patients' quality of life satisfaction was significantly higher than that of age ≤40 years old patients (OR =3.8,95 ％ CI 1.36-10.66; OR =3.6,95 ％ CI 1.24-10.43).The patients of the occupation of service sectors,workers,and patients with free occupation have a decreased satisfactions compared with that of farmer patients (OR =0.46,95 ％ CI 0.12-1.75; OR =0.75,95 ％ CI 0.27-2.12; OR =0.94 95 ％ CI 0.45-1.98).There was a increasing satisfactions in administrative and the intellectuals (OR =1.11,95 ％ CI 0.34-3.62; OR =1.33,95 ％ CI 0.35-5.10).Patients with primary school educations as a reference for comparison,the quality of life of patients with associated college and above degree were increased than patients with primary school (OR =1.15,95 ％ CI 0.43-3.04),and were decreased in the patients of the high and middle school (OR =0.98,95 ％ CI 0.46-2.11; OR =0.63,95 ％ CI 0.26-1.54; OR =0.15,95 ％ CI 0.02-1.27).The quality of life satisfaction of long period patients (7-12 months,13-24 months,24 months after the operation)was significantly higher than that of short period patients with 6 months(OR =1.94,95 ％ CI 0.65-5.83; OR =6.32,95 ％ CI 2.17-18.38; OR =8.47,95 ％ CI 2.92-24.56,P ＜ 0.001).Conclusion The doctors need focus on relative knowledge education of perioperation.It is important to inform patients and their spouses to have the knowledge of female physiology,fully understanding the impact of the extent of surgery on sexual life of patients to enhance the confidence and improve the life quality of patients.

Objective To compare the effects of loop electrosurgical excision procedure(LEEP knife)and microwave on cervical erosion and study the nursing effects.Methods One hundred and fifty cases of cervical erosion patients from January to December 2013 in our hospital were selected and randomly divided into observation group and control group with 75 cases in each group.Patients in the observation group were treated with LEEP knife and the control group with microwave treatment.All patients were nursed conventionally.The operative time,blood loss and efficacy of two groups were analyzed.Result Patients in the observation group had less blood loss,shorter operation time and a better curative effect than the control group with statistical difference(all P<0.05).Conclusions Compared with microwave treatment,LEEP knife can effectively treat the cervical erosion.Preparation before operation,mental care and knowledge-related nursing are critical for the smooth manipulation of the operation.

Objective To explore the changes of gene and protein expressions of nuclear factor-κB(NF-κB) and tumor necrosis factor-α (TNF-α) in immature rats with pilocarpine-induced epilepsy treated with ghrelin. Methods The pllocarpine-induced epilepsy model in immatured rats were built, then the rats were divided into three groups: Ghrelin-treated group, saline-treated group and model group, meanwhile the normal control group was set. The NF-κB and TNF-α levels of gene and protein in the cerebral cortex of immature rats were detected. Results The expression levels of gene and protein of NF-κB and TNF-α were increased in model group,but decreased in the normal control group;NF-κB and TNF-α levels in Ghrelin treated group were obviously lower than those of saline-treated group and model group(P < 0. 05). Conclusion The protective mechanism of Ghrelin for nerve cell is cutting down the expressions of NF-κB and TNF-α in the cerebral cortex of immature rats with epilepsy and lessening inflammatory reaction in neurocytes.

AIM: To evaluate the influences of triptolide on serum cytokines, symptoms and pulmonary function in patients with steroid - resistant asthma, so as to investigate if there is therapeutic effect of triptolide on these patients. METHODS: Sixteen patients with steroid - resistant asthma were randomly divided into two groups (A and B, n =8 for each group). All of the patients took procaterol (50 - 100 μg/d) and theophylline (400 mg/d) orally as baseline treatment. Additionally, triptolide was prescribed for group A (33 μg, orally, three times per day for 4 weeks). Asthmatic symptom score calculation, serum cytokines ( interferon - γ, IFN - γ; interleukin - 4, IL - 4; and interleukin - 5, IL - 5)determination and pulmonary function test (FVC%, FEV1%, PEF%, V50% and V25% ) were undertaken before and at the end of the study. RESULTS: At baseline, no significant difference was found between group A and group B with respect to the above mentioned indices. Following the administration of triptolide, group A had significantly increased serum IFN -γlevel, FVC%, FEV1%, PEF%, V50% and V25%, and significantly decreased asthmatic symptom score and serum IL-4, IL-5 levels (P＜0.01 compared with baseline in the same group, and P＜0.05 compared with group B at the end of the study). Compared with baseline, no significant change was observed for group B regarding all the indices at the end of the study. CONCLUSION: Triptolide in combination with procaterol and theophylline may be a novel and effective strategy for the treatment of steroid - resistant asthma.

The present investigation reports the chemical composition of the Rhus typhina L. stem identified via mass spectrometry and NMR as gallic acid, 1-O-galloyl-β-D-glucose, tryptophan, scopolin, methyl gallate, fustin, quercetin, rutin, and 1,2,3,4,6-penta-O-galloyl-β-D-glucose. The antioxidant properties and the chemical composition contents of the R. typhina L. stem grown in different regions in China were de-termined. To determine the antioxidant activity, a total phenolic content analysis, 2, 2-diphenyl-1-pi-crylhydrazyl radical scavenging activity assay, ferric reducing antioxidant power assay, andβ-carotene linoleic acid model system were conducted. The results showed that the Rhus typhina L. stem possessed high antioxidant capacities due to its high phenolic content. The contents of the nine isolated compounds were determined by UPLC-ESI-MS/MS. The calibration curves of the nine isolated compounds were linear within the concentration range and the average recoveries were high. The result showed that 1-O-galloyl-β-D-glucose, gallic acid, methyl gallate, and 1,2,3,4,6-penta-O-galloyl-β-D-glucose could be the compounds mainly responsible for the antioxidant capacity of the R. typhina L. stem. This reveals that the R. typhina L. stem is a good source of antioxidants.

AIM: To investigate the protective effect and mechanisms of di-ao-xin-xue-kang (DK) on myocardial ischemia-reperfusion. METHODS: Models of myocardial ischemia-reperfusion were constructed with sixteen mongrel dogs. The left ventricular pressure (LVSP), the marximal/minimum rate of LVSP (?dp/dt max) and the serum aspartate aminotransferase (AST), creatine kinase (CK), lactate dehydrogenase (LDH), malondialdehyde (MDA) were determined before and 90 minutes after occlusion, 120 and 240 minutes after reperfusion, and the MDA content in myocardial cell membrane prepared at 240 minutes after reperfusion was determined. The oxygen free radical was assayed with electron spin resonace spectroscopy (ESR) technique. RESULTS: ① LVSP and ?dp/dt max in the normal saline control (NS) group decreased with the time progress of occlusion-reperfusion, and it was the same in DK group, but the levels were significantly higher than that in NS group (P

Objective To analyze the quality of life and its influencing factors in elderly patients with malignant tumors in rehabilitation period. Methods A comprehensive questionnaire on the quality of life of the elderly patients with malignant tumors was designed with reference to the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 scale. The quality of life of patients with malignant tumor diagnosed in Shanxi Cancer Hospital from November 2009 to November 2013 was investigated and evaluated. All data were analyzed by SPSS 13.0 software, and SAS9.2 software was used for statistical analysis. The influencing factors were analyzed by multiple linear regression analysis. Results Sex, marriage and other factors had no influence on the quality of life in elderly patients with malignant tumors (P> 0.05). The social and medical factors, such as age, educational level, number of children, medical form (economic status), discharge time, treatment style, etc were the main factors affecting the quality of life of patients (all P<0.05).Conclusions Poor physical condition,social relationship,psychological factors and medical factors have effect on quality of life in elderly patients with malignant tumor.Strict adherence to doctor's advice and popularization of relevant knowledge, providing family warmth, social support and economic support can improve the quality of life of patients with malignant tumor.