Objective]The aim of this study was to investigate the level of serum C3,C4 and HDL-C in patients with coronary heart disease and the correlation between C3,C4 and HDL-C in patients with coronary heart disease.[Methods]We collected 251 cases of patient diagnosed with coronary artery disease by coronary angiography in Sun Yat-sen Memorial Hospital ,Sun Yat-Sen University from 2015-12 to 2016-07 and collected over our Boji Medical Center healthy people in 214 cases. These patients were divided into acute coronary syndrome group with 180 cases and stable coronary heart disease group with 71 cases. Each test results was adopted from clinical laboratory of Sun Yat-Sen Memorial Hospital ,Sun Yat-Sen University.[Results]Compared with the healthy control ,the difference of serum C3,C4 and HDL-C from acute coronary syndrome group and stable coronary heart disease group,was statistically significant(P<0.05). However,in patients with acute coronary syndrome and stable coronary artery disease groups,there was no significant correlation(P > 0.05)between C3,C4 and HDL-C. In healthy group,complement C3 negatively correlated with HDL-C,the difference was statistically significant(P<0.05).[Conclusions]In patients with coronary heart disease, the level of C3 and C4 increased,while the level of HDL-C decreased ,and inflammation may affect the relevance judgments between complement and HDL-C.

To investigate the relationship between SORL1 gene polymorphism and sporadic Alzheimer’s disease（Alzheimer’s disease，AD）.Methods The SNP loci of SORL1 gene rs1010159，rs2282649，rs3824968，rs1699102，rs3781836，rs2070045，rs3781834，rs641120，rs689021，rs668387 and rs12364988 in 131 sporadic AD patients and 128 healthy controls in Xinjiang were detected by PCR amplification and DNA sequencing. Results There was no significant difference between AD group and control group in the polymorphisms of SNP loci rs1010159，rs2282649，rs3824968，rs1699102，rs3781836，rs2070045，rs3781834，rs641120，rs689021，rs668387，rs12364988 and rs985421 of SORL1 gene（P>0.05）.Conclusion The polymorphisms of SNP loci rs1010159，rs2282649，rs3824968，rs1699102，rs3781836，rs2070045，rs3781834，rs641120，rs689021，rs668387，rs12364988 and rs985421 of SORL1 gene have no correlation with the pathogenesis of AD.