Objective:To explore effects of nurses' cognition of patient safety culture and psychological capital on career growth, so as to provide a basis for promoting nurses' career growth.Methods:This research was a cross-sectional survey. From July to August 2019, a total of 480 nurses from 3 ClassⅢ Grade A hospitals in Tianjin were selected as the research objects by means of convenient sampling. General information questionnaire, Hospital Survey on Patient Safety Culture (HSOPSC) , nurses' Psychological Capital Questionnaire (PCQ) and Career Growth Scale (CGS) were used to investigate the patients. In this study, 480 questionnaires were issued and 465 valid questionnaires were collected, with an effective recovery rate of 97%. Stratified regression analysis was used to analyze the mediating effect of psychological capital, and AMOS was further used to construct the structural equation model for verification.Results:The total mean score of HSOPSC of 465 nurses was (3.91±0.30) , the total mean score of PCQ was (4.66±0.35) and the total mean score of CGS was (3.62±0.41) . Nurses' cognition of patient safety culture was positively correlated with career growth ( r=0.525, P<0.01) . Nurses' cognition of patient safety culture was positively correlated with psychological capital ( r=0.470, P<0.01) . There was a positive correlation between psychological capital and career growth ( r=0.557, P<0.01) . The direct path coefficient of patient safety culture cognition on career growth was 0.33. Psychological capital played a part of the mediating role in the relationship between patient safety cultural cognition and career growth. The mediating effect was 0.30, and the mediating effect accounted for 47.6% of the total effect. Conclusions:The career growth of nurses is at a medium level, and psychological capital plays an intermediary role between the patient's cultural awareness of safety and career growth. Nursing managers should take effective measures to improve nurses' cognition of patient safety culture, at the same time improve nurses' psychological capital level, so as to promote nurses' career growth.

Objective? To evaluate the rehabilitation effect of phase I cardiopulmonary rehabilitation on patients with coronary artery bypass grafting(CABG). Methods? Chinese and English databases were searched via computer including PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, VIP, with the time set as the database establishment date to 31st January of 2019, to obtain randomized controlled trials of phase I cardiopulmonary rehabilitation in CABG. Meta-analysis of the included studies was performed by RevMan 5.3 software. Results? A total of 8 studies were included, according to the Meta analysis, 6 min walking distance increased in the phase I cardiopulmonary rehabilitation patients group(MD=56.46,95%CI 32.82-80.09,P＜ 0.001), the percentage of forced vital capacity(FVC) in expected value(1%) increased (MD=7.30,95%CI 2.59-12.00,P=0.002), the percentage of forced expiratory volume in first second(FEV1) in the expected value(1%) increased (MD=7.93,95%CI 3.13-12.72,P=0.001), hospital stay decreased(MD=-5.35,95%CI -9.67--1.03,P=0.002), incidence of postoperative arrhythmia decreased(MD=0.42, 95%CI -0.21-0.85),P=0.002), but the improvement effect of quality of life was not significan(t P＞ 0.05). Conclusions? Phase I cardiopulmonary rehabilitation can improve the activity endurance, pulmonary function, shorten the hospitalization time and reduce the incidence of postoperative arrhythmia, but it can not significantly improve the quality of life. Due to the small number of included studies and the heterogeneity of some indicators, the results of this study still need to be verified by multicenter, large sample and high-quality randomized controlled trials.

Wound infection is becoming a considerable healthcare crisis due to the abuse of antibiotics and the substantial production of multidrug-resistant bacteria. Seawater immersion wounds usually become a mortal trouble because of the infection of Vibrio vulnificus. Bdellovibrio bacteriovorus, one kind of natural predatory bacteria, is recognized as a promising biological therapy against intractable bacteria. Here, we prepared a B. bacteriovorus-loaded polyvinyl alcohol/alginate hydrogel for the topical treatment of the seawater immersion wounds infected by V. vulnificus. The B. bacteriovorus-loaded hydrogel (BG) owned highly microporous structures with the mean pore size of 90 μm, improving the rapid release of B. bacteriovorus from BG when contacting the aqueous surroundings. BG showed high biosafety with no L929 cell toxicity or hemolysis. More importantly, BG exhibited excellent in vitro anti-V. vulnificus effect. The highly effective infected wound treatment effect of BG was evaluated on mouse models, revealing significant reduction of local V. vulnificus, accelerated wound contraction, and alleviated inflammation. Besides the high bacterial inhibition of BG, BG remarkably reduced inflammatory response, promoted collagen deposition, neovascularization and re-epithelization, contributing to wound healing. BG is a promising topical biological formulation against infected wounds.

Post-traumatic stress disorder (PTSD) is a psychiatric disease that seriously affects brain function. Currently, selective serotonin reuptake inhibitors (SSRIs) are used to treat PTSD clinically but have decreased efficiency and increased side effects. In this study, nasal cannabidiol inclusion complex temperature-sensitive hydrogels (CBD TSGs) were prepared and evaluated to treat PTSD. Mice model of PTSD was established with conditional fear box. CBD TSGs could significantly improve the spontaneous behavior, exploratory spirit and alleviate tension in open field box, relieve anxiety and tension in elevated plus maze, and reduce the freezing time. Hematoxylin and eosin and c-FOS immunohistochemistry slides showed that the main injured brain areas in PTSD were the prefrontal cortex, amygdala, and hippocampus CA1. CBD TSGs could reduce the level of tumor necrosis factor-