Objective:To conduct Meta-analysis of the effectiveness of improved activity mode in prevention of peripherally inserted central catheter (PICC) related thrombosis in tumor patients.Methods:PubMed, The Cochrane Library, CNKI, Wanfang Database and VIP database were conducted computer retrieval of studies on improved activity mode and PICC related thrombosis in tumor patients from January 1, 2010 to December 31, 2019. A total of two researchers independently screened literature, extracted data and evaluated the quality of literature. The RevMan 5.3 software was used for Meta-analysis of the included studies.Results:A total of 7 randomized controlled trials (RCT) were included in this study. Meta-analysis results showed that compared with the conventional catheterization side upper limb exercise group, the incidence of catheter-related venous thrombosis in tumor patients in the improved activity mode group was reduced ( OR=0.22, 95% CI=0.13-0.38, P<0.01) , and the maximum blood flow velocity of the axillary vein was increased ( MD=1.03, 95% CI=0.64-1.42, P<0.01) . Conclusions:Improved activities on the limb of catheterization can effectively accelerate the blood flow velocity of the axillary vein after PICC catheterization in tumor patients and reduce the occurrence of catheter-related venous thrombosis.