1.Current treatment of vascular Behcet′s disease
Runze SONG ; Si CAI ; Ruisheng QU ; Yu WANG ; Dong ZHOU ; Anping ZHANG
International Journal of Surgery 2021;48(9):643-648
Behcet′s disease is a chronic, multisystemic, inflammatory disease characterized by recurrent episodes of mucous membranes, eyes, musculoskeletal, blood vessels, central nervous system, and gastrointestinal tract.The treatment of Behcet′s disease varies according to the degree of organ involvement, gender and age of the patient, and there is no standard treatment. Behcet′s disease can be divided into vascular type, gastrointestinal type and neural type. Vascular type often leads to high mortality and disability rate.Glucocorticoids, azathioprine and cyclophosphamide are still recommended as first-line treatments for vascular Behcet′s disease.However, with the use of tumor necrosis factor inhibitors, they are an acceptable option for the treatment of refractory vascular Bezier′s disease.This article reviews the current treatment of vascular Behcet′s disease.
2.Application and development of shape memory polymers in endovascular therapy
Yanyi ZHOU ; Zhaolong LI ; Yaoming ZHANG ; Wenyang HE ; Ruisheng QU ; Chaoqiang CUI ; Dong ZHOU
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery 2020;27(11):1362-1366
As one of the stimulus-response polymeric intelligent materials, shape memory polymers have been widely applied in biomedicine due to their better biocompatibility, higher controllability, stronger deformation restorability and biodegradability compared with shape memory alloys and shape memory ceramics. This review will introduce the structural principles of shape memory polymers and summarize their applications in the treatment of vascular diseases, especially in endovascular therapy. At the same time, the related technical problems and the future of shape memory polymers are prospected. With the continuous development of processing technology and materials, it can be predicted that shape memory polymers will be more widely used in the medical field.
3.State-of-the-art and outlook of drug-eluting stents
Wenyang HE ; Yanyi ZHOU ; Yaoming ZHANG ; Hao GU ; Ruisheng QU ; Chaoqiang CUI ; Dong ZHOU
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery 2022;29(07):930-934
Implantation of drug-eluting stents (DES) is one of the most effective treatment for intraluminal vascular diseases such as vascular stenosis caused by atherosclerosis. Antiproliferative drugs offered by could significantly reduce the restenosis of blood vessels, which is beneficial to interventional therapy in more advanced and complex vascular diseases. This review sumarizes the state-of-the-art of the DES based on the function of loaded drug and material of the stents. We hope this review can provide basic information of DES for clinicians and researchers to make more rational choices in practical applications. Moreover, this review also propses the prospects of drug-loaded stents.