Objective: To compare the different therapeutic effects of acupuncture and Phenolphthalein for constipation due to intestinal qi stagnation. Methods:A total of 50 patients with constipation due to intestinal qi stagnation were randomly divided into an acupuncture group and a medication group by the random digital table, 25 cases in each group. The patients in the acupuncture group were treated by puncturing Gongsun (SP 4), Sanyinjiao (SP 6), Taichong (LR 3), Zusanli (ST 36), Shangjuxu (ST 37), Hegu (LI 4), Lieque (LU 7), and Tianshu (ST 25), once every day, and 7 d as one course, for continuous 3 courses; while the patients in the medication group were given Phenolphthalein, 7 d as one course, for continuous 3 courses. Compared the Cleveland clinic constipation score (CCS) between the two groups after one course, 3 courses and 3 months after the treatment, as well as the frequency of defecation within one week. Results:After one week of treatment, CCS scores and frequency of defecation per week were significantly changed in both groups compared with those before treatment (P<0.05), and CCS scores and frequency of defecation per week were improved more significantly in the patients of the medication group than in those of the acupuncture group (P<0.01). After 3 weeks of treatment, CCS scores and frequency of defecation per week were significantly changed in both groups compared with those before treatment (P<0.05), and CCS scores and frequency of defecation per week were improved more significant in the patients of the acupuncture group than in those of the medication group (P<0.05). Three months after the end of treatment, CCS scores and frequency of defecation per week were significantly changed in both groups compared with those before treatment (P<0.05), and CCS scores and frequency of defecation per week were improved more significantly in the patients of the acupuncture group than in those of the medication group (P<0.05). Conclusion:Acupuncture and medication are effective in the treatment of constipation due to intestinal qi stagnation. Their short-term therapeutic effect is similar, but the long-term therapeutic effect is better in the acupuncture group than in the medication group.

Objective To investigate clinical and pathological features of lupus erythematosus profundus (LEP)of the scalp in children.Methods A retrospective study was carried out on 5 children with LEP.The clinical and histopathological features,treatment and prognosis of LEP were analyzed.Results The 5 children with LEP included 2 boys and 3 girls with a median age at onset of 5 months (range,2-38 months) and a median clinical course of 15 months (range,4-72 months).Clinically,the patients presented with arc-shaped or circular purple atrophic plaques on the scalp complicated by alopecia.The occipitalia and tempora were the most commonly involved sites.Antinuclear antibodies (ANA) and extractable nuclear antigens (ENAs) were negative in all the patients.Main histopathological changes were hyaline degeneration of the fat,mucin deposition and local aggregation of lymphocytes in fat lobules.Of the 5 patients,2 were treated with oral prednisone (1.5-2 mg/kg/day),1 with oral hydroxychloroquine (5 mg/kg/day),1 with oral prednisone (1.5 mg/kg/day) combined with hydroxychloroquine (5 mg/kg/day),and another 1 with topical halometasone cream and 0.03％ tacrolimus ointment.Lesions were remissed after 2-3 months of treatment,and subsided with growth of new hairs after 6 months.No recurrence was observed during a 1.5-year follow-up.Conclusion Prednisone and hydroxychloroquine are markedly effective for LEP,and pediatric patients with LEP may be treated by topical highpotency glucocorticoids and calcineurin inhibitors.

As an important nucleus of basal ganglia, globus pallidus was concerned to involve in the neural mechanism of Parkins's disease (PD). Previous studies of PD patients and animal model indicate that neurotransmitters and receptors are changed in globus pallidus neurons, the balance between inhibition and excitation is broken in the output nuclei of basal ganglia, and globus pallidus neurons display bursting and oscillatory discharge, the synchronous tendency of neighboring neurons enhances. These neurophysiological changes are associated with PD symptoms, such as bradykinesia, rigidity and tremor, which reflects that globus pallidus plays an important role in the process of PD. In the present paper, the recent advances in pathophysiology in globus pallidus, its clinical application in treatment of Parkinson's disease, and the study direction in the future are reviewed.

Objective To investigate the characteristics and clinical significance of ocular vestibular evoked myogenic potential (oVEMP) and caloric test in Meniere disease (MD) at different hearing stages.Methods Fifty-five patients(52.8±15.8 years old) with MD were divided into stage 1(9 cases,48.8±13.8 years old), stage 2(9 cases,46.0±16.3 years old), stage 3(23 cases,50.3±13.5 years old) and stage 4(cases 14, 53.5±16.2 years) respectively according to the pure tone audiometry.They were evaluated by oVEMP and caloric test.Results The abnormal rates of oVEMP were 55.6%, 66.7%, 78.3%, 78.6%,and caloric tests were 22.2%, 33.3%, 78.3%,and 85.7% respectively in stage 1, 2, 3, and 4 MD patients.The amplitudes of oVEMP in stage of 1, 2, 3, and 4 MD patients were 4.3±4.0 μV,3.5±2.3 μV,2.5±2.4 μV,and 1.3±0.5 μV,respectively.Conclusion The abnormal rates of oVEMP and caloric tests in MD patients increased with the degree of hearing impairment and the amplitudes of oVEMP were decreased, suggesting that utricle and horizontal semicircular canal injuries were aggravated.

The 7th version (2015) of national examination syllabus for licensed pharmacists has been put into effect for more than two years,which has caused extensive concern of all sectors of society.This article summarized and evaluated thinking of the revision,content of the new version and the situation implementation to provide reference for further improving the system of licensed pharmacists.

Objective To investigate the prevalence of anxiety and depression among the persons with disabilities in Shanghai and the factors related to them. Methods From November to December, 2014, 731 persons with disabilities were consecutively enrolled in this cross-sectional study. They were assessed with Self-rating Anxiety Scale (SAS) and the Self-rating Depression Scale (SDS). Binary Logistic regression analysis was employed to reveal potential related factors of anxiety and depression. Results The prevalence rates of anxiety and depression among the disabled in Shanghai were 9.58%and 8.48%, respectively. The duration (OR=0.967, P<0.05) and severity (OR<1, P<0.05) of disability were associated with depression, whereas retiral (OR=2.047, P<0.05), living alone or in care unit (OR=3.073, P<0.01) and duration of disability (OR=0.956, P<0.01) were associated with anxiety. Conclusion The frequency of anxiety and depression is mild among the persons with disabilities in Shanghai, and a special intervention is needed.

Objective This study aims to examine expression of Caveolin -1 in non smoking cell lung cancer(NSCLC)and to discusses the relationship between expression of Caveolin -1 and the Epidermal growth factor receptor mutations .Methods Immunohistochemical staining was used to determine the Caveolin -1 ex-pression and ARMS-qPCR was used to measure EGFR mutations in 40 cases of lung cancer tissue .The clinical pathological characteristics and correlations in patients were analyzed .Results The expression of Caveolin -1 in human lung cancer was significantly lower than that in normal lung tissue ,and negatively correlated with EGFR mutations ,which was statistically significant .Conclusion Caveolin -1 expression is negatively correlated with EGFR mutations in non-small cell lung cancer and related to the histologic type .Caveolin-1 may be a molecu-lar target for diagnosis and judgment of NSCLC .

OBJECTIVE:To provide reference for the perfection of relevant system of licensed pharmacist qualification exami-nation in China. METHODS:Using the self-made network questionnaire,the survey was conducted among the candidates who par-ticipated in the National Licensed Pharmacist Qualification Examination in 2016 about their evaluation on relevant system of li-censed pharmacist qualification examination. The survey data was analyzed statistically so as to put forward suggestions. RE-SULTS:A total of 4209 questionnaires were collected,including 4205 valid questionnaires with effective rate of 99.90%. 41.90%of the interviewed candidates thought that the examination paper was a good reflection of"to determine the content of the examina-tion according to the need"principle;nearly half of them thought the paper content was reasonable;69.25% thought that the prac-tice of examination paper for the overall promotion of candidates'professional skills and practice level of performance were not sat-isfactory. 80.10% and 68.94% of the interviewed candidates thought that the outline and guidelines of the new national licensed pharmacist qualification examination could guide the preparation of examination. More than half of the interviewed candidates be-lieved that pharmaceutical services and practical experience should be added in examination outline. 49.51% of the candidates thought the persons majoring in pharmacy and TCM should be allowed to participate in this examination. 39.52% of the candidates thought that the requirements of education degree for applicants should be increase to college or bachelor degree or above. 57.18%of the respondents considered that the validity of qualified branch scores should be extended. CONCLUSIONS:The vast majority of the candidates give a high evaluation on the new version of the national licensed pharmacist qualification examination outline and guideline,while some people think that the outline of the examination,the form of examination and entry criteria and other aspects need to be improved. It is recommended that the state attach importance to the cultivation of pharmacy service personnel,raise the threshold of entry and examination,improve the quality of examination quality and improve the form of examination and focus on requirements according to the different areas of practice examination.

In the automatic analysis system of the kidney-tissue image, boundary enhancement for glomerulus area is a vital step. Complex characteristics of kidney-tissue image leads to the difficulty in boundary features description. This paper suggests a kind of feature template under the special boundary definition. A nonlinear threshold surface is constructed by neural network, then the proper surface can be selected to enhance boundary with the influence of error permissibility being taken into account. Experimental results indicate that this learning method with error permissibility can enhance the boundary of glomerulus and suppress noises at the same time, so it can obtain good processed effects and have a fine performance highly adaptive to various sample images.
Humans ; Image Processing, Computer-Assisted ; Kidney Glomerulus ; pathology ; Neural Networks (Computer)

Objective To explore the clinical features and risk factors of primary gout in Xinjiang area.Methods A total of 364 patients with gout and 546 healthy crowd were divided into two groups.A unified questionnaire was used to investigate and detect relevant biochemical indicators.Related biochemical indexes were examined and analyzed.Logistic regression model was established to analyze the risk factors related to gout.Results The mean age of onset of gout was 42.95±11.93.More than two joints were involved in56.32％ of patients with gout.BMI, SUA, GLU, BUN, CREA, TG, TC, LDL-C of gout group were significantly higher than those of control group (P＜0.01), while HDL-C was significantly lower than that of control group (P＜0.01).The advanced age, high uric acid hematic disease, high blood pressure, high blood sugar, smoking, drinking, family history of gout, BMI, high TG levels, and high creatinine hematic disease, high blood LDL-C may be risk factors for gout occurence (OR=3.767, 103.482, 3.621, 2.934, 3.140, 3.482, 4.198, 1.102, 1.498, 1.102, 1.498), while aerobic exercise regularly (three times or more a week) is the protection factor gout occurs.Conclusion The average age of patients with gout in Xinjiang is lower than the national level.The distribution of the degree of culture of patients with gout in Xinjiang may have no obvious rule, and the population with medium and low degree of culture is the main affected population.More than half of patients with gout are now involved in more than two joints.The most common associated with gout is hypertension.Beer/liquor and high-fat diet are the most common dietary factors for patients with gout in Xinjiang.The advanced age, hyperuricemia, hypertension, hyperglycemia, smoking, drinking, hypercreatinine, BMI, high-TG, high LDL-C and family history of gout may all increase the risk of gout, while aerobic regular exercise (more than 3 times per week) may reduce the risk of gout.