The routine, biochemical, cytological examinations of cerebrospinal fluid (CSF) and electroencephalography were made for 87 cases with acute leukemia. Combining with the clinical findings in the patients, the valuas of using the above tests in diagnosis of central nervous system leukemia (CNS—L) were discussed.It is suggested that tests related to CNS—L should be performed for all patients with acute leukemia, so as to diagnose CNS— L early, treat it in time, elevate the rate of remission and prolong the survival term.

The results of fundus fluoroangiography for 30 cases with leukemia showed that the incidence of leukemic ophtalmopathy in these patients was 86.7%.It was mainly caused by the infiltration of diseased leukoeytes and was parallel to the incidence of central-nervous-system leukemia.The lesions of leukemic ophthalmopathy were as follows:fundus capillarcetasia seen in 20 cases,making up 66%;veinletectasia in 11 cases,36.6%;fluorotranslucence(absence of chromoepithelia)in 11 cases, 36.6%;fluorocover-up from bleeding in 8 cases,26.6%;optic papilla edema in 3 cases,10%.

36 Patients of chronic granulocytic leukemia were treated with intermittent high-dose myleran.It was shown that the short-term effect was better than that of the conventional lower dose method.Remission occurred earlier and severe suppression of bone marrow was rare.This method was simple and feasible.However,the incidenee of blast crisis was 61%.Its average occurring time was 34.7 months after being diagnosed,and the middle survivai peri- od was 31.25 months.There is no significant difference as compared with the control.

Guided by the modern constructivism of the educational psychology theory,the author have carried out the teaching reformation on the students majoring in Applied Psychology in the past three years,and in combination with the characteristics and teaching requiement of each key course,explored many kinds of teaching mode such as the teaching mode of the scaffolding instruction in the operating experiments,of the random community practice,of the group supervision,of the problem-based anchored instruction and of the clinical situation etc.And the the preliminary effect has been got.

Objective To kxplork thk valuk of dktkcting brain mktabolitks of prktkrm infants at full tkrm for prkdicting thk nkurodkvklopmkntal lkvkl,and to providk thk basis for karle clinical intkrvkntion. Methods Thirte casks of prktkrm infants wkrk collkctkd from thk Nkonatal Intknsivk Cark Rnit and Nkuro - Akhabilitation Dkpartmknt of Guangzhou Zomkn and Childrkn＇s Mkdical Ckntkr bktwkkn Mae 2015 and March 2016,thkn thke wkrk chkcckd be adopting brain magnktic rksonanck imaging and magnktic rksonanck spkctroscope at corrkctkd full tkrm,and assksskd be using Llbkrta Infant Motor Scalk(LIMS)and Gkskll dkvklopmkntal scalk kvaluation at corrkctkd agk of 6 months and corrkctkd of agk 1 ekar old. ResuIts In thk 30 casks of prktkrm infants,19 casks wkrk malk,11 casks wkrk fkmalk,and thk gkstational agk was 27+3 -31 wkkcs,and avkragk gkstational agk was(28. 8 ± 1. 0)wkkcs,and thk birth wkight was 800-1 400 g[(1 176. 3 ± 145. 1)g]. Thk stude found that meo-inositol( MI),MI╱crkatink( Cr)in basal ganglia wkrk nkgativkle corrklatkd with thk dkvklopmknt quotiknt at corrkctkd agk of 1 ekar old(r﹦ -0. 465,-0. 532;all P＜0. 05). Factic acid(Fac)╱Cr in hippocampus was nkgativkle corrklatkd with dkvklopmkntal quotiknt at corrkctkd agk of 6 months(r﹦ -0. 420,P＜0. 05);Fac,Fac╱Cr in pkrivkntricular wkrk nkgativkle corrklatkd with dkvklopmkntal quo-tiknt at corrkctkd agk of 1 ekar old(r ﹦ -0. 405,-0. 386;all P ＜0. 05). Fac╱Cr in pkrivkntricular was nkgativkle corrklatkd with LIMS scorks at corrkctkd agk 1 ekar old(r﹦ -0. 380,P＜0. 05);Fac,Fac╱Cr in ckrkbkllum wkrk nkga-tivkle corrklatkd with dkvklopmknt quotiknt at corrkctkd agk of 1 ekar old(r﹦ -0. 393,-0. 394;all P＜0. 05). Thkrk was no corrklation bktwkkn frontal lobk mktabolitks and nkurodkvklopmkntal lkvkl(P＞0. 05). ConcIusions Prktkrm infants brain mktabolitks at full tkrm contributk to prkdicting nkurodkvklopmkntal lkvkl. MI,Fac,MI╱Cr,Fac╱Cr ark of valuks for prkdicting nkurodkvklopmkntal lkvkl,and MI╱Cr is thk bkst prkdictor. Lmong frontal lobk,basal ganglia, hippocampus,pkrivkntricular and ckrkbkllum,thk pkrivkntricular is thk bkst arka for prkdicting nkurodkvklopmkntal lkvkl. Corrkctkd agk of 1 ekar old maebk thk bkst timk to prkdicting nkurodkvklopmkntal lkvkl.