Objective To explore the influence of nursing intervention on quality of life of uremic patients with restless legs. Methods 60 uremic patients with restless legs in our hospital from June 2009to December 2010 were divided into the observation group and the control group with 30 patients in each group according to the nursing method.The control group was given conventional nursing,the observation group was given strengthening sleep nursing and psychological care on the basis of the control group.The psychological status,sleep status and quality of life were compared between the two groups. Results The psychological improvement in the observation group was better than that in the control group,sleep time and insomnia proportion in the obeervation group was better than that in the control group,the score of life quality in the observation group was better than that in the control group. Conclusions Nursing intervention can improve adverse psychological state in uremic patients with restless legs,improve aleep quality and quality of life.

OBJECTIVE:To study the stability of Baicalin in Biyuanling granules and predicate its validity duration. METHODS:The content of Baicalin in Biyuanling granules was determined by RP HPLC on Diamonsil ODS C_(18) chromatographic column(200 mm?4.6 mm,5?m) with methanol -water- phosphoric acid(53:47:0.2) used as mobile phase.The detective wavelength was set at 274 nm.The stability of Baicalin in Biyuanling granules was determined by classical accelerated test process in constant temperature and its validity duration was computed.RESULTS:The disintegration constant of Baicalin at 25℃was K = 4.592?10 ~6 h~1,and the validity duration was t_(0.9)=2.62 years.CONCLUSION:The method developed in this study was proved to be scientific,reasonable and suitable for the study of the stability of Biyuanling granules.

Objective To compare the effects of Yangxue Qingnao Granule and Xueshuantong Capsule on abnormal coagulation system in migraine patients. Methods All patients were divided into group A and group B according to sex. Each group contained 60 patients. Yangxue Qingnao Granule and Xueshuantong Capsule was administrated in group A and group B respectively. The adjusting functions of abnormal coagulation system of migraine patients in the two groups were compared.Results Xueshuantong Capsule was better than Yangxue Qinguao Granule in adjusting blood coagulation system (P< 0.05). Conclusion The clinical usage of Xueshuantong capsule has better effect than Yangxue Qingnao Granule on regulating abnormal blood coagulation system.

BACKGROUND: Although nickel and chromium are essential elements of human body, over high concentration of them will produce many adverse effects to human body, therefore biological safety of nichrome material for dental restoration deserves attention.OBJECTIVE: To observe the changes of nickel and chromium content at 6 months and 1 year after porcelain-fused-to-nichrome crown restoration, and compare to healthy controls to investigate the long-term safety of nichorme in oral cavity.DESIGN, TIME AND SETTING: A case-control observation was performed between January 2006 and December 2007 at the First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei Province, China.PARTICIPANTS: Sixty patients who visited Department of Stomatology, the First Affiliated Hospital of Hebei North University, between January and December 2006 were included in test group, including 28 male, 32 female, the mean age was 40 years. Each of them had 3 anterior maxillary teeth restored by porcelain-fused-to-nichrome crowns, without other metal fillings or protheses. Sixty healthy cases visited the hospital at the same time were used as control, including 30 male, 30 female, the mean ages was 39 years.METHODS: Fasting venous blood of participants in two groups was harvested sterilely at 6 months and 1 year after test group restoration, serum nickel and chromium content were determined using graphite furnace atomic absorption spectrometry.MAIN OUTCOME MEASURES: ① Serum nickel content changes in test and control group. ②Serum chromium content changes in test and control groupRESULTS: All cases were involved in result analysis. ① Serum nickel content changes in test and control group: At 6 months postrestoration, there was no significant difference in serum nickel content between test group and control group (P>0.05). At 1 year after restoration, serum nickel content of test group was significantly higher than that of control group (P<0.05). ② Serum chromium content changes in test and control group: There was no significant difference in chromium content between test and control group at 6 months and 1 year after test group restoration (P>0.05).CONCLUSION: Nickel and chromium released from porcelain-fused-to-nichrome crowns after restoration under oral environment, serum nickel content had an increasing tendency with the prolongation of restoration time, but in small quantity and within biosafety range, to identify whether the increasing tendency will increased continuously with the prolongation of restoration time needs long-term follow-up.

0.05). Conclusion:After Ni-Cr-Based porcelain-fused-to-metal crown application, the metal ion can be released and absorbed by human body. But the content is almost harmless to human body.

Objective To evaluate short-term curative effect of chloroquine combined with traditional Chinese medicine in treatment of erosion lichen planus. Methods 40 cases were chosen and randomly divided into two groups. The treatment group included 20 cases were treated with chloroquine combined with traditional Chinese medicine. The control group with 20 cases was treated only with chloroquine. The curative effect of the two groups were compared. Results Comparing the two groups, in the treatment group, the pain was remarkably relieved and the erosion areas were obviously smaller. Significant changes were observed statisticly. The overall effectiveness of the treatment group was 85% ,but that of the control group was 65%. Conclusion The treatment of chloroquine combined with traditional Chinese medicine have a short-term clinical effect on erosion lichen planus.

Aortic arch atheroma is one of the causes of embolic stroke. With the deepening of research on aortic arch atheroma, its relationship with stroke is more and more clear, particularly the aortic arch plaque thickness ≥4 mm, is associated with cryptogenic stroke, stroke recurrence, and other vascular events. Although aortic arch atheroma and clinical features of stroke have been further understood, there are still many doubts.

Objective To investigate the influence of congenital cleft lip or cleft palate on total respiratary compliance (C T) in child.Methods Sixty children without congenital malformation (control group) and 240 children with congenital cleft lip or cleft palate (test group), scheduled for selected operation, were divided into 5 subgroups according to the age range: 1 12 months,1 3 years,4 7 years and 8 12 years,respectively. With the mechnical ventilation following intratracheal intubation after anesthesia induction, P ET CO 2 was maitained at 4 4.6kPa. The C T was measured with Datex Ultima monitor.Results Compared with the control level in the same age subgroup, C T remained unsignificant changes in all subgroups of cleft lip and in 1 12 months and 1 3 years subgroups of cleft palate, but decreased significantly in 4 7 years and 8 12 years subgroups of cleft palate(P

Objective To explore an effective method of repairing the old rupture of patellar tendon. Methods We designed a new 井-shaped apparatus for traction and fixing which was to be used, under the dynamic conditions, to reduce the patella, loosen the quadriceps m. of thigh, repair the tendon of knee cap and facilitate postoperative exercises with the fixing apparatus on. Results We used the apparatus to repair the tendon of knee cap in 6 cases. The follow up of 8 to 56 months (averaging 26 months) showed that their functions of the knee joint were all satisfactory. Conclusions The 井-shaped external fixation device can be used under the dynamic conditions to repair the old rupture of patellar tendon with the advantages of little contracture of the knee cap and quadriceps m. of thigh, easy fixation after repair and suture, and early exercise of the knee joint. This novel method is simple and recommendable.

Objective To develop a superparamagnetic iron oxide (SPIO)-based MR probe containing vascular endothelial growth factor(VEGF) to investigate their biological and chemical properties and targeting effect of colorectal cancer cells in vitro. Methods The anti-VEGF-SPIO probe was fabricated with VEGF antibody and SPIO through chemical method. Its biological and chemical properties and reflexivity were tested with SDS-PAGE and MRL The SW620 cells incubated with anti-VEGF-SPIO probe for 30, 60 and 90 minutes respectively and compared with marrow mesenchymal stem cell at 37℃. The comparison among groups was conducted by using analysis of variance and LSD-t test. The MRI results were confirmed by the Prussian blue staining. The comparison among groups was performed by analysis of variance and factorial experiment. Results SPIO-based MR probe containing VEGF was successfully contributed and isolated. The reflexivity of anti-VEGF-SPIO probe was 0.0426×10~6 mol/s. The immunofluorescence and prussia blue stain proved high expression of VEGF in SW620 cells. Anti-VEGF-SPIO probe and SW620 cellscombined at 37℃ in vitro MRI proved the SW620 cells incubated with anti-VEGF-SPIO probe appeared hypointense on T_2WI and T_2~* WI. MR signal were 392±7,91±8,264±10 for 30, 60 and 90 minutes respectively, which were statistically different from that before incubation 679±12 (F=4735.489, P< 0.01). The intensity decreased most significantly at 60 minutes in vitro. Its MR signal 82±7 were statistically different compared with marrow mesenchymal stem cell 689±43, t=39.167,P<0.05). While SW620 cells incubated without SPIO were not statistically different compared with marrow mesenchymal stem cell, which were 419±59 and 400±41 respectively(t=-0.718,P>0.05). Conclusion Nanoscale iron particles containing the anti-vascular endothelial growth factor molecular probe can evaluate tumor angiogenesis at the receptor level, which provides a new way of the tumor angiogenesis diagnosis and anti-angiogenesis therapy.