OBJECTIVETo investigate the imaging features and diagnostic value of MRI and CT in diagnosis of spinal tuberculosis by comparing study.

METHODSFrom May 2014 to December 2014, 32 patients with spinal tuberculosis were diagnosed as patients with spinal tuberculosis, and the data of MRI and CT were retrospectively analyzed.

RESULTSPatients with lesions appeared respectively in the cervical, thoracic and lumbar spine; CT diagnosis of bone destruction and vertebral disc soft tissue injury rate is lower than that of MRI, the intervertebral disc injury diagnosed rate higher than that of MRI, P < 0.05, the difference is statistically significant.

CONCLUSIONCT and MRI in the diagnosis of spinal tuberculosis imaging studies are different, and combination of both can improve the diagnosis rate, can prevent and treat in a timely manner, so as to improve the treatment effect.

Several genetic polymorphisms of the aldosterone synthase gene(CYP11B2),which may influence the plasma aldosterone levels,had been reported to influence the blood glucose levels.In addition to the effects of sodium()(and consequently water) resorption and potassium excretion(),aldosterone could be involved in the development and progression of diabetes and its chronic complications.This paper also discussed the therapeutic significance of aldosterone receptor antagonists on the occcurance of chronic diabetic complications.

Objective To analyse the correlation between hepatitis B virus infection in mother and immune effect of hepatitis B vaccine in infant so as to explore ways to prevent mother-to-infant transmission.Methods 8 022 aged from 7 months to 2 years old children and their mothers were selected.The children's HepB immunization were investigated.The serological investigation of mother and children were tested by the colloidal gold tripes and ELISA methods.The HBV genotype were detected among HBsAg positive mother.Results The mother's carry rate of HBsAg was 2.43% while the children's was 0.45%.The protect rate of HepB was 81.48%.127 genotype C were detected among 146 HBsAg positive mothers.There were 26 pair of mothers and their children whose's HBsAg were both positive.Nine of the mother's HBeAg and HBcAb were positive.While five of the mother's HBeAb and HBcAb were positive,and ten of the mother's HBcAb were positive.The differences of the three were statistically significant (?2=6.03,P

Objective To investigate the imaging features and diagnostic value of MRI and CT in diagnosis of spinal tuberculosis by comparing study. Methods From May 2014 to December 2014, 32 patients with spinal tuberculosis were diagnosed as patients with spinal tuberculosis, and the data of MRI and CT were retrospectively analyzed. Results Patients with lesions appeared respectively in the cervical, thoracic and lumbar spine; CT diagnosis of bone destruction and vertebral disc soft tissue injury rate is lower than that of MRI, the intervertebral disc injury diagnosed rate higher than that of MRI, P<0.05, the difference is statistical y significant. Conclusion CT and MRI in the diagnosis of spinal tuberculosis imaging studies are different, and combination of both can improve the diagnosis rate, can prevent and treat in a timely manner, so as to improve the treatment effect.

Objective: To understand the pathogenic spectrum characteristics of enteroviruses of non-enterovirus (EV) 71 and non-coxsackievirus (CV) A16 associated with hand, foot and mouth disease (HFMD) in Xinjiang. Methods: Specimens were collected from HFMD patients infected with non-EV-A71 non-CV-A16 enterovirus from 2011 to 2016 in Xinjiang. The virion protein (VP)1 gene sequence was amplified by reverse transcription polymerase chain reaction (RT-PCR) and sequenced. Sequencing and genotyping were performed through erterovirus genotyping tool. Results: A total of 119 sequences were obtained, 15 human enterovirus serotypes were identified including CV-A6, CV-A10, CV-A4, CV-A8, CV-B1, CV-B3 (4 strains), CV-B4, CV-B5, ECHO30, ECHO12, ECHO14, CV-A9, CV-A24, PV1 and PV3. The composition ratio of CV-A6 among non-EV-A71 non-CV-A16 enterovirus in 2013, 2015 and 2016 was 87.9%, 79.5% and 88.3% respectively. Conclusions The pathogens causing HFMD in Xinjiang included more than 17 kinds of human enterovirus serotypes. Since 2013, CV-A6 has become the main pathogen of HFMD simultaneously or alternately with EV-A71 and CV-A16.

Objective To investigate the effects of fast-track anesthesia on hemodynamics,a-wakening quality,and neurological function in patients undergoing cardiac surgery.Methods A to-tal of 130 patients undergoing cardiac surgery were selected and were randomly divided into control group(n=65)and study group(n=65).The clinical data of the patients were collected,and the hemodynamic parameters,awakening quality,neurological function,and incidence of postoperative complications were compared between the two groups.Results The study group had lower dosages of fentanyl citrate injection and rocuronium bromide compared with the control group(P＜0.05).After anesthesia induction and tracheal intubation,the heart rate(HR),mean arterial pressure(MAP),cardiac output(CO),cardiac index(CI),and bispectral index(BIS)were changed compared with before anesthesia induction in both groups,but the degree of change in the study group was less than that in the control group(P＜0.05).The study group had shorter postoperative recovery time to breathe,awakening time,extubation time,ICU stay time,and postoperative hospital stay compared with the control group,the incidence of restlessness after extubation was lower in the study group than in the control group(P＜0.05).The study group had lower levels of neuron-specific enolase(NSE)and β-amyloid protein(Aβ)at 180 min after arterial cannulation compared with the control group(P＜0.05).The total incidence of postoperative complications was 3.08％in the study group,which was lower than 16.92％in the control group(P＜0.05).Conclusion Fast-track anesthesia can effectively stabilize hemodynamics in patients undergoing cardiac surgery,improve awakening quality and neurological function,and reduce the incidence of postoperative complications.

Objective To investigate the effect of nursing intervention guided with self-management on self-management behavior and quality of life of kidney-transplant patients .Methods 192 eligible subjects were randomly divided into the experimental group ( n =99 ) and the control group ( n =93 ) .The control group received conventional nursing and follow-up visits while the experimental group adopted nursing intervention guided with self-management in addition , including collective education , group discussion , individual guidance and information.Self-management scale and quality of life scale were used to assess patients ’ self-management behavior and quality of life before and 3 months after intervention .Results There was no statistically significant difference of self-management behavior and quality of life between two groups before intervention (P>0.05). But after intervention , there was statistically significant difference of self-management behavior and quality of life between two groups (t=9.25,-6.65, respectively;P<0.05).In the experimental group, the score of self-management scale before and after intervention was respectively (93.22 ±3.28) and(100.44 ±4.44), the score of quality of life was (12.16 ±1.46)and(10.92 ±0.92), and the differences were statistically significant (t=-9.11,5.01, respectively; P<0.05).Conclusions Nursing intervention guided with self-management can improve the self-management level and quality of life of kidney transplant patients and has clinical significance for preventing rejection and increasing survival rate .

Objective To investigate the effects of fast-track anesthesia on hemodynamics,a-wakening quality,and neurological function in patients undergoing cardiac surgery.Methods A to-tal of 130 patients undergoing cardiac surgery were selected and were randomly divided into control group(n=65)and study group(n=65).The clinical data of the patients were collected,and the hemodynamic parameters,awakening quality,neurological function,and incidence of postoperative complications were compared between the two groups.Results The study group had lower dosages of fentanyl citrate injection and rocuronium bromide compared with the control group(P＜0.05).After anesthesia induction and tracheal intubation,the heart rate(HR),mean arterial pressure(MAP),cardiac output(CO),cardiac index(CI),and bispectral index(BIS)were changed compared with before anesthesia induction in both groups,but the degree of change in the study group was less than that in the control group(P＜0.05).The study group had shorter postoperative recovery time to breathe,awakening time,extubation time,ICU stay time,and postoperative hospital stay compared with the control group,the incidence of restlessness after extubation was lower in the study group than in the control group(P＜0.05).The study group had lower levels of neuron-specific enolase(NSE)and β-amyloid protein(Aβ)at 180 min after arterial cannulation compared with the control group(P＜0.05).The total incidence of postoperative complications was 3.08％in the study group,which was lower than 16.92％in the control group(P＜0.05).Conclusion Fast-track anesthesia can effectively stabilize hemodynamics in patients undergoing cardiac surgery,improve awakening quality and neurological function,and reduce the incidence of postoperative complications.

Objective:To explore the influencing factors of 31-day unplanned readmission in obstetrics.Methods:The medical records and relevant clinical data of 29 public hospitals in a province in 2017 were collected to construct a two-level logistic regression model on the influencing factors of 31-day unplanned readmission.Results:In 2017, there were 71 330 obstetric patients discharged from 29 public hospitals, 690 of whom were unplanned readmitted in 31 days, accounting for 0.97%. The type of medical insurance payment, number of previous hospitalization, condition of previous hospitalization, age, history of cesarean section, pregnancy complications and complications during delivery were all the factors influencing the 31-day unplanned readmission of obstetrics.Conclusions:The condition of 31-day unplanned readmission could be influenced by the factors of sociology, previous visit and clinical. These factors should be considered reasonably in the evaluation and management of obstetric quality.

Objective:To analyze regional differences in MMACHC gene variations among patients with cblC-type methylmalonic acidemia (MMA) in China and to explore the relationship between these variations and neonatal screening, biochemical markers and prognosis.Methods:Retrospective case summary. Clinical and laboratory data, including general condition, biochemical markers and genetic analysis, were collected from 1 859 cblC MMA patients from 2005 to 2023. Patients were divided into 7 groups according to their regions: north China, northeast China, east China, central China, south China, southwest China and northwest China. They were also classified into neonatal screening and non-neonatal screening groups. Mann-Whitney U and Kruskal-Wallis tests were used to compare biochemical marker levels. In contrast, the Chi-square test was applied to compare MMACHC gene variant frequencies, neonatal screening proportion, onset age and prognosis between groups. Results:Among 1 859 cases of cblC MMA, 1 019 were male and 840 were female, with a consultation age of 1.0 (0.1, 5.0) month. A total of 1 787 cases carried compound heterozygous or homozygous variants and only 1 variant site was identified in 72 cases. The 10 most frequent variants were c.609G>A (1 238 cases), c.658_660delAAG (343 cases), c.80A>G (284 cases), c.482G>A (239 cases), c.567dupT (191 cases), c.656_658delAGA (131 cases), c.217C>T (109 cases), c.394C>T (105 cases), c.445_446delTG (51 cases) and c.1A>G (50 cases). The frequency of the c.609G>A was the lowest in northwest China (28.8% (44/154), χ2=-18.42, P<0.05). The frequency of the c.567dupT was the most common in southwest China (25.0% (20/80), χ2=71.70, P<0.001) and c.656_658delAGA had the highest frequency in northeast China (9.3% (19/205), χ2=32.08, P<0.001). Non-missense variants (91.2% (62/68), 88.5% (46/52)) and early-onset patients (90.0% (36/40), 94.4% (34/36)) were both more prevalent in southwest and south China ( χ2=14.95, 31.69, both P<0.05). The proportion of neonatal screening was the lowest in south China (22.2% (8/36), χ2=98.48, P<0.05), where the mortality rate was the highest (19.1% (4/21), χ2=38.98, P<0.001). East China exhibited the highest frequency of missense variants (21.5% (339/1 579)), the highest proportion of patients identified through neonatal screening (54.5% (465/853)), and a more significant proportion of patients with good prognosis (36.6% (227/621), χ2=14.57, 93.49, 38.98, all P<0.05). In addition, the c.482G>A variant was more frequent in patients diagnosed by neonatal screening compared to those diagnosed by other methods (8.3% (132/1 586) vs. 5.9% (122/2 060), χ2=7.97, P<0.05). Conclusions:The frequency of MMACHC gene variation varies across different regions. The c.609G>A was least frequent in northwest China, c.567dupT was most common in southwest China, and c.656_658delAGA was most prevalent in northeast China. South China had the lowest neonatal screening rate and the highest mortality. At the same time, east China exhibited the highest frequency of missense variants, the highest proportion of patients identified through neonatal screening and the best prognosis. The c.482G>A variant was more frequent in patients diagnosed by neonatal screening compared to those diagnosed by other methods.