Objective To observe the effect of dapagliflozin on cardiac function in patients with heart failure after emergency percutaneous transluminal coronary intervention in acute ST segment ele-vation myocardial infarction.Methods A total of 100 patients with acute myocardial infarction un-derwent emergency PCI were randomly divided into study group(52 cases)and control group(48 ca-ses).The study group was given dapagliflozin on the basis of standardized treatment of myocardial in-farction,and the control group was given conventional treatment of myocardial infarction.Cardiac ul-trasound related indexes[left ventricular ejection fraction(LVEF),left ventricular end-diastolic di-ameter(LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic vol-ume(LVEDV)],plasma N-terminal brain natriuretic peptide(NT-proBNP)level,6-minute walking test(6MWT)results.The incidence of adverse reactions and major cardiovascular adverse events(MACE)were compared between the two groups during follow-up.Results After 6 months of treat-ment,LVESD,LVEDD and LVEDV in the two groups were significantly lower than before treatment,and LVEF was significantly higher than before treatment(P＜0.05);the LVESD,LVEDD and LVEDV of the study group were significantly lower than those of the control group,and LVEF was sig-nificantly higher than that of the control group(P＜0.05).The NT-proBNP in the two groups was significantly lower than before treatment,and was significantly lower in the study group than that in the control group(P＜0.05).The 6MWT distance of the study group was significantly longer than that of the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions and MACE between the two groups(P＞0.05).Conclusion Dapagliflozin can improve cardiac function in patients with heart failure after emergency PCI of acute ST segment elevation my-ocardial infarction.

Objective To observe the effect of dapagliflozin on cardiac function in patients with heart failure after emergency percutaneous transluminal coronary intervention in acute ST segment ele-vation myocardial infarction.Methods A total of 100 patients with acute myocardial infarction un-derwent emergency PCI were randomly divided into study group(52 cases)and control group(48 ca-ses).The study group was given dapagliflozin on the basis of standardized treatment of myocardial in-farction,and the control group was given conventional treatment of myocardial infarction.Cardiac ul-trasound related indexes[left ventricular ejection fraction(LVEF),left ventricular end-diastolic di-ameter(LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic vol-ume(LVEDV)],plasma N-terminal brain natriuretic peptide(NT-proBNP)level,6-minute walking test(6MWT)results.The incidence of adverse reactions and major cardiovascular adverse events(MACE)were compared between the two groups during follow-up.Results After 6 months of treat-ment,LVESD,LVEDD and LVEDV in the two groups were significantly lower than before treatment,and LVEF was significantly higher than before treatment(P＜0.05);the LVESD,LVEDD and LVEDV of the study group were significantly lower than those of the control group,and LVEF was sig-nificantly higher than that of the control group(P＜0.05).The NT-proBNP in the two groups was significantly lower than before treatment,and was significantly lower in the study group than that in the control group(P＜0.05).The 6MWT distance of the study group was significantly longer than that of the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions and MACE between the two groups(P＞0.05).Conclusion Dapagliflozin can improve cardiac function in patients with heart failure after emergency PCI of acute ST segment elevation my-ocardial infarction.