Objective To evaluate the effectiveness of intense pulsed light (IPL) therapy for meibomian gland dysfunction (MGD).Methods A prospective senal cases observational study was designed.Thirty patients with MGD (60 eyes)in the Tianjin Medical University Eye Hospital from October 2017 to April 2018 were enrolled.All the subjects received IPL therapy at baseline,1 week and 3 weeks after the baseline,respectively.Before each treatment and 3 months after treatment,subjective symptoms (ocular surface disease index [OSDI] questionnaire,Standard Patient Evaluation of Eye Dryness [SPEED] questionnaire),palpebral margin score,lipiview ocular surface interferometer lipid layer thickness (LLT) measurement,tear meniscus height (TMH) and noninvasive tear film breakup time (NIBUT) measurement were performed to detect and assess the IPL treatment effect.The safety of the IPL treatment was evaluated through the visual acuity and intraocular pressure.Results The OSDI score,SPEED score and the score of lipid excretion and secretion of meibomian gland before treatment were significantly higher than those of the other three time points (all at P＜0.01).The TMH before treatment was significantly lower than that of the other three time points (all at P＜0.01).No significant differences were obtained on first time NIBUT,blinking times and incomplete blink ratio among different time points (all at P＞0.05).After treatment,the average thickness of tear film lipid layer was slightly increased,and the secretion of tarsal gland was improved.There were no adverse reactions during the treatment and follow-up,no changes in corrected vision,and the intraocular pressure fluctuated within the normal range.Conclusions IPL therapy can alleviate the symptoms and signs of dry eye of MGD patients,and the effect can last for at least 3 months.IPL is an effective and safe method in treatment of MGD.

[Objective]To explore SUN Congtian,a bibliophile,library scientist and proofreader in the Qing Dynasty,his achievements in collecting and reviewing ancient books of Chinese medicine and his academic thoughts on medicine.[Methods]Using the method of literature research,it summarized the medical bibliographies in SUN Congtian's Shangshantang Bibliograph,and studied Huoren Jinglun,Shizhi Medical Talk.[Results]In terms of ancient medical books,SUN Congtian collected and reviewed many ancient medical books,and put forward the idea of purchasing and collecting ancient medical books and editions.In terms of medical theory,he enlightened the student YE Tianshi's"collateral disease"theory and SHEN Jin'ao's"depression disease"diagnosis and treatment thought,and put forward the medical theory of"spleen and stomach construction".[Conclusion]SUN Congtian's Shangshantang Bibliography records 28 ancient Chinese medicine books,including many rare and precious editions.Huoren Jinglun and Shizhi Medical Talk have innovated medical theory and promoted the development of medical academia.His medical academic thought needs to be further explored and sorted out.