1.Open-window bone grafting combined with internal fixation for the treatment of inter-articular calcaneal fractures.
China Journal of Orthopaedics and Traumatology 2009;22(9):714-715
Adult
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Calcaneus
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injuries
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surgery
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Female
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Fracture Fixation, Internal
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methods
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Fractures, Bone
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diagnostic imaging
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surgery
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Humans
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Male
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Middle Aged
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Radiography
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Treatment Outcome
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Young Adult
2.Attempt to use heuristic teaching to cultivate students' ideation
Yu-xia LIU ; Rui-ling CHEN ; Feng-e SUN ; Feng-lin ZHU ; Chun-tao YU ; Rui-lan NG ZHA
Chinese Journal of Medical Education Research 2011;10(8):1007-1008
Heuristic teaching is propitious to cultivating students' ideation. We have used different heuristic modes for example problems, stories, contrast, associationin and so on to cultivate medical students' ideation in pathobiology and immunology teaching and acquired good effect.
3.Effects of dexamethasone on MRL/Ipr mice with systemic lupus erythematosus complicated with cognitive dysfunction
Yuanyuan WANG ; Jie TANG ; Lin SHEN ; Jiangyan LI ; Cheng ZHA ; Rui WANG ; Kun HU ; Jin XI ; Jianrong CHANG ; Changhao XIE
Journal of Central South University(Medical Sciences) 2017;42(3):251-256
Objective:To evaluate the effects of dexamethasone on systemic lupus erythematosus complicated with cognitive dysfunction.Methods:Ten wild type mice and 20 MRL/lpr mice were applied for the research.MRL/lpr mice were randomly assigned to a MRL/lpr group and a MRL/lpr + dexamethasone (1.5 mg/kg) group.Interleukin-6 (IL-6),IL-1β,and tumor necrosis factor alpha (TNF-α) in serum and hippocampus were detected.The protein phosphorylation levels of phosphoinositide 3-kinase (P-PI3K),protein kinase B (P-Akt),NF-kappa-B inhibitor alpha (P-IκBa) and nuclear transcription factor kappa-B p65 (P-NF-κB p65) were detected by Western blot,the level of P-NF-κB p65 also was detected by immunohistochemistry.Results:Treatment with dexamethasone (1.5 mg/kg) alleviated the cognitive dysfunction and decreased the levels of IL-6,IL-1 β and TNF-α in serum and hippocampus,and reduced the levels of P-PI3K,P-Akt,P-IκBa and P-NF-κB p65 in hippocampus in MRL/lpr mice.Conclusion:Dexamethasone may play a protective role in the cognitive function by decreasing the levels of TNF-α and IL-1 β in the hippocampus of MRL/lpr lupus mice.
4.The methods of shorting proximal femoral and total hip arthroplasty for Crowe IV dysplastic hip of adults.
Ning LIU ; Zhen-gang ZHA ; Ping YAO ; Cheng NI ; Hong-sheng LIN ; Guo-pu WANG ; Zhi-zhong LI ; Rui PAN ; Hao WU ; Shuang-li WANG
Chinese Journal of Surgery 2008;46(4):277-279
OBJECTIVESTo discuss the methods and outcome of shorting proximal femoral and total hip arthroplasty for Crowe IV dysplastic hip of adults.
METHODSFrom July 2000 to February 2006, 13 cases of osteoarthritis secondary to severe development dysplastic hip were treated by total hip replacement and the shorting proximal femoral.
RESULTSThe duration of follow-up ranged from 4 months to 55 months. The average score increased from 36.9 to 84.1 points after the surgery according to Harris. All the patients could walk independently. Their paces were improved obviously and the function of their hips was satisfactory.
CONCLUSIONSThe treatment by total hip arthroplasty and the shorting of posterior femoral is effective and efficient for osteoarthritis secondary to Crowe IV development dysplastic hip in adults. The long-term followup is necessary for further study.
Adult ; Aged ; Arthroplasty, Replacement, Hip ; methods ; Female ; Femur ; surgery ; Follow-Up Studies ; Hip Dislocation ; etiology ; surgery ; Humans ; Male ; Middle Aged ; Osteotomy ; methods ; Retrospective Studies ; Treatment Outcome
5.Combined intravenous and intra-arterial thrombolysis in patients with acute ischemic stroke
Rui FU ; Xing-Hui ZHAO ; Dong HUANG ; Tong NG ZHA ; Wei DAI ; Mao-Lin HE
Chinese Journal of Neuromedicine 2011;10(11):1088-1091
Objective To evaluate the efficacy and safety of combined intravenous(Ⅳ)and intra-arterial(IA)thrombolysis in patients with acute ischemic stroke.Methods A prospective and open-label trial was performed on 40 patients with acute ischemic stroke in the carotid artery system within 3 hours of symptom onset,admitted to our hospital from May 2005 to February 2009; these patients were treated with recombinant tissue plasminogen activator(rt-PA)by a combined Ⅳ and IA thrombolysis approach.The percentage of favorable prognosis,incidence of symptomatic intraeranial haemorrhage(SICH)and fatality rate in these patients were compared with those research results from foreigners having large samples.Results According to the results of DSA,recanalization rate (grade-2 or-3 in the Thrombolysis in Cerebral Infarction[TICI]scale)after Ⅳ thrombolysis was 25%(10/40),rate of serious cerebrovascular stenosis was 7.5%(3/40),including 2 patients with stenosis of the internal carotid artery(ICA)and 1 with stenosis of the middle cerebral artery(MCA),and rate of vascular occlusion was 67.5%(27/40),including 9 patients with ICA occlusion and 18 with MCA occlusion.Twenty-four patients adopted combined Ⅳ and IA thrombolysis approach after 180-390 min(mean[304±61]min)of stroke onset,and their recanalization rate was 79.2%(19/24).Re-infarction rate was 7.5%(3/40).Three months after the thrombolysis,percentage of good functional outcomes(modified Rankin Scale[mRS])scores:0-2)was 60%(24/40),which had significant differences as compared with that with NINDS placebo treatment(27.2%[85/312],P<0.05); percentage of good functional outcomes(NIHSS score ≤ 1)was 52.5%(21/40),which had significant differences as compared with that of groups with NINDS rt-PA treatment(31%[97/312]),NINDS placebo treatment(20%[62/312])and interventionalmanagement of stroke(IMS,27.5%[22/80]),P<0.05); SICH was noted in 2.5%(1/40)and fatality in 10%(4/40)accepted thrombolysis,and no significant differences were noted as compared with those in groups with NINDS rt-PA treatment,NINDS placebo treatment,emergency management of stroke EMS and IMS (P>0.05).Conclusion Combined Ⅳ and IA thrombolysis is an effective and safe new method in treating patients with acute ischemic stroke by providing good vascular recanalization rate and good clinical outcomes.
6.Coronavirus disease 2019 in pregnant and non-pregnant women: a retrospective study.
Ying ZHA ; Ge CHEN ; Xun GONG ; Yuan-Yuan WU ; Xing-Guang LIN ; Jian-Li WU ; Ya-Fei HUANG ; Yu-Qi LI ; Ying ZHANG ; Dong-Rui DENG ; Su-Hua CHEN ; Fu-Yuan QIAO ; Ling FENG ; Wan-Jiang ZENG ; Ke-Zhen LI ; Hai-Yi LIU
Chinese Medical Journal 2021;134(10):1218-1220