Objective To study efficacy of L-ornithine-L-aspartate (Hepa-Merz) in treatment for nonalcoholic steatohepatitis (NASH) and its effect on lowering serum level of triglycerine MethodsTotally, 30 patients with nonalcoholic steatohepatitis diagnosed by liver function test, B ultrasound scanning and liver biopsy were treated by intravenous infusion of L ornithine L aspartate (Hepa Merz) 10 g daily for 21 days Activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and serum level of triglycerine (TG) were determined for all the cases before and after treatment Results Activities of serum ALT and AST and serum level of TG were restored to normal in 29 (96 7%) and in 28 (93 3%) of 30 patients, respectively, after treatment No serious adverse effects were found during treatment Conclusions L ornithine L aspartate (Hepa Merz) is a safe and effective drug in treatment for nonalcoholic steatohepatitis, and can lower serum level of triglycerine significantly

OBJECTIVE To investigate the bleeding site,clinical features,treatment methods and curative effect of difficult-to-control epistaxis. METHODS The clinical data of 127 patients with difficult-to-control epistaxis admitted for treatment were retrospectively analyzed to investigate the common bleeding sites,clinical features,and curative effect. RESULTS There were statistically significant differences in the bleeding sites among patients of different age groups(P=0.000),whether they were combined with hypertension 2,3 grades(P=0.030),and whether patients taking long-term anticoagulants(P=0.000). Among the enrolled patients,14 patients were successful in the secondary hemostasis. Among the patients with two successful bleeding stops,the one-time cure rate of patients with hypertension 2,3 grades was significantly different from that of patients with hypertension 1 grade and non-hypertension(P=0.000). CONCLUSION Male patients with difficult-to-control epistaxis are more than female patients. The common bleeding sites are related to age,hypertension 2,3 grades,and long-term use of anticoagulants. Nasal endoscopic electrocoagulation is the preferred treatment method. The cure rate of electrocoagulation is related to blood pressure,and blood pressure control is necessary for patients with poor blood pressure control.