Reversible splenial lesion syndrome can be caused by viral infection. Rubella generally occurs in childhood, and it is rarely accompanied by neurological complications in adulthood. A 35-year-old man visited our hospital due to conjunctival injection, mild fever, and headache 3 days after experiencing skin rash. Brain magnetic resonance imaging (MRI) revealed distinct lesions involving white matter in the splenium of the corpus callosum approximately 3 days following the onset of symptoms. Enzyme immunoassay performed on serum and CSF samples was positive for rubella virus IgM. A follow-up brain MRI was performed 24 days after the onset of symptoms, and reduced lesion size with decreased signals were observed on diffusion weighted image. This case showed that rubella infection can result in reversible splenial lesion accompanied by only mild neurological symptoms.
Rubella

No abstract available.
Pregnancy ; Rubella

Studying the harmful effects of Rubella infection in pregnant women. Adults and children were infected rubella virus through upper respiratory tract. In pregnant women, virus in blood stream go through placenta and infected in some cells of fetus, caused congenital defects such as deafness (58%), ocular abnormalities (13%), heart defects (13%). Definite diagnosis based on paraclinical tests because of clinical symptoms weren’t valuable. Isolation of rubella virus in throat mucus, urine, and others were not frequent, this test commonly carried out in suspected congenital rubella syndrome. Serological diagnosis was used most commonly: IgG (+) indicating there was an immune response with rubella. It’s very important to define exactly new infected pregnancy, based on the increase of IgG titer or the presence of specific serum IgM in only serum sample. The best prevention measure is vaccination before pregnancy
Rubella ; Pregnancy

No abstract available.
Rubella* ; Vaccination*

No abstract available.
Glycoproteins* ; Oligodendroglia* ; Rubella virus* ; Rubella*

No abstract available.
Diploidy* ; Humans* ; Measles* ; Mumps* ; Rubella Vaccine* ; Rubella*

No abstract available.
Antibodies* ; Korea* ; Prevalence* ; Rubella*

An outbreak of rubella occurred from 2nd March to 4th April, 2001, in three districts: Cau Giay, Tu Liem, Dong da of Ha Noi. There were 62 rubella cases aged from 1 to 25 years. Most of the cases were observed in age group 5-9 years (80,6%). The typical symptoms were fever (100%), rash (87,1%), itching (56,4%), coryza (35,5%). Serum samples from 9 cases were tested by MAC-ELISA, and all were positive.
Rubella ; Disease Outbreaks

No abstract available.
Prognosis* ; Rubella* ; Syphilis, Congenital*

OBJECTIVE: The study determined the ocular manifestations as well as the clinico-demographic, maternal profile, and management of infants with Congenital Rubella Syndrome (CRS) seen at the Philippine Children‘s Medical Center from 2015 to 2021. MATERIALS AND METHODS: A retrospective chart review was conducted among children less than 1 year of age, born between January 1, 2015, to December 31, 2021, who met the clinical case definition of CRS. RESULTS: Among the 398 reviewed charts, 312 were suspected cases of CRS, 79 were probable, and 7 were laboratory-confirmed. Ocular conditions were found in 54 suspect cases, 14 probable cases, and 2 confirmed cases. Congenital cataract was the most common ocular manifestation in infants with CRS, and associated clinical manifestations were mainly congenital heart disease followed by microcephaly and hearing loss. CONCLUSION This study highlighted the challenge of CRS diagnosis in the country, with most cases diagnosed based on clinical manifestations and a limited number of laboratory-confirmed cases due to the expense and availability of confirmatory tests. These findings emphasize the importance of recognizing ocular manifestations as an early indicator of CRS and the need for improved surveillance and awareness of the disease to facilitate early recognition and management.
Rubella Syndrome, Congenital