Chemokine is a family of small chemotactic cytokines.Chemokine mainly locates in neutrophile granulocyte,monocyte,macrophage,T lymphocyte and B lymphocyte,and some cells and immunoactive cells also secret cytokines.Researches showed that chemokine plays important roles in many patho-physiological activities,such as inflammatory response,infection procedure,wound healing,regulation of immunity,angiogenesis,invasion and metastases of cancer,etc..Some chemokine factors,such as hyperglycemia,hypoxia,oxidative stress,stimulate the ocular histiocytes to up-regulate the expressions of CXC chemokines and CC chemokines,which participate in the development of choroidal neovascularization and ocular neovascular diseases.This article reviews current progress in chemokine and the relationship between chemokines and ocular neovascular diseases,especially in diabetic retinopathy (DR) and age-related macular degeneration (AMD) etc..

AlM: To investigate the operation methods and clinical effects of foldable intraocular lens secondary implantation after lens-vitrectomy in residual capsular with traumatic eyes. METHODS: During January 2012 to January 2014, foldable intraocular lens was implanted on 47 cases following lens - vitrectomy in residual capsular with traumatic eyes 3~6mo. Follow-up period was 6 ~12mo, averaged (8. 21±2. 63)mo.RESULTS:All of 47 eyes had successful operation at one time, and position deviation was not appeared. The naked vision of the last postoperative follow-up was (0. 44±0. 19). Compared with best corrected visual acuity (0. 41±0. 23), and There was no significant difference between visual acuity of preoperative and last follow-up period ( t=0. 879, P=0. 342). No severe complication was found. CONCLUSlON: Secondary implantation of foldable intraocular lens is a safe and reliable method for correcting ametropia after lens- vitrectomy in residual capsular with traumatic eyes.

For probing into therapeutic effect, action, and proper and effective administration way of Jiang Ni Fu Sheng Liquid for treatment of acute cerebral hemorrhage, 150 cases were assigned at random to two groups to receive different therapies. Integral of hyponeuria, change of disturbance of consciousness, change of blood pressure, CT and clinical therapeutic effect were observed before and after treatment in the two groups. Results showed that the therapeutic effect in the treated group was obviously superior to that in the control group, with a markedly effective rate of 51. 1% and an effective rate of 90. 0%. It is suggested that Jiang Ni Fu Sheng Liquid has the action of relieving disturbance of consciousness, promoting recovery of nervous function, keeping stability of blood pressure, accelerating absorption of cerebral hemorrage, alleviating cerebral edema and hemorrhage of digestive tract, and so on.

Objective To explore the effect classroom teaching quality evaluation on the improve-ment of teaching quality. Methods In-service teachers offering classes to undergraduates majoring in clinical medicine during the period of 2010 to 2011 in Tangshan Clinical Hospital of Hebei Medical University were enrolled as research objectives. Totally 128 teachers(majored in 16 disciplines), screened out from the enrolled teachers, met the criteria and passed through the evaluation in terms of class quality of lessons. They were arranged in descending order and the top 15%were grouped as the preeminent group while the 15%at the bottom were classified as standard group and the rest 70%as good group. Descriptive analysis was made to appraise results from four respects:major and discipline, records of formal school-ing, professional ranks and titles and length of teaching experience. Results Based on the analysis of teaching situation in major disciplines, the top 3 disciplines possessing the largest proportion of preemi-nent teachers were neurology ( 50%) , otolaryngology-head and neck surgery ( 40%) and surgery (20.6%). When it comes to the analysis of formal schooling records of teachers , there is no distinct dis-crepancy in rate of standard reaching between teachers with postgraduate degree and teachers with gradu-ate degree. However, rate of standard reaching was slightly higher in teachers with other degrees than teaching with undergraduate degree or above. In the analysis of professional ranks and titles, the proportion was 94.6%in teachers with senior professional title(associated senior professional title and senior profes-sional title) and the teachers with medium grade professional title only occupied a proportion of 5.4%. In the dimension of teaching years, rate of outstanding and good teachers was relatively high in teachers with 8 teaching years and teacher with less than 3 teaching years, whereas the outstanding rate was low and rate of standard reaching was high in teachers with the 3-4 teaching years. Conclusions Measures to enhance the quality of teaching can be found out according to the analysis of influencing factors of teaching quality evaluation.

OBJECTIVE: To investigate the regulation of geniposide on blood sugar and lipids in diabetic rats. METHODS: ELISA assay was used to determine the content of insulin in vitro and in vivo, and MTT was used to determine the cell viability.RESULTS Geniposide prevented pancreatic beta damage induced by high glucose, and attenuated glucose-stimulated insulin secretion in the presence of 25 mmol•L-1 glucose. Furthermore, geniposide ameliorated insulin resistance, and decreased the contents of total cholesterol (TC) and triglyceride (TC) in STZ-induced diabetic rats. CONCLUSION: Geniposide is beneficial to improve the dysfunction of pancreatic beta cells induced by high glucose, and might be a promising lead compound for the treatment of diabetes.

ObjectiveTo evaluate the effect of low dose of dexamethasone on the blood glucose concentration in patients undergoing craniotomy. Methods20 consecutive patients undergoing craniotomy without a preexisting metabolic disorder were prospectively randomized into 1 of 2 groups: Dexamethasone (group D, n=10) and Normal Saline (group S, n=10), who were given dexamethasone 10 mg intravenous bolus or a saline placebo preoperatively. Arterial glucose concentrations were measured immediately before and after treatment and hourly for 5 hours intraoperatively. ResultsThe arterial glucose concentration in group D increased significantly(F=3.133,P<0.05), while those in group S keep stable. Compared with group S, arterial glucose concentration in group D increased significantly 180 min after dosing(P<0.01). ConclusionIf dexamethasone is used during craniotomy, perioperative blood glucose level should be carefully monitored and controled.

Objective To analyze the research status of private hospitals in China for policy recommendations of their development.Methods Using CNKI as the object to retrieve,and key words ofprivate hospital ,social capital to run hospitals or the titles of'private hospitals ,social capital to run hospitals to retrieve 853 articles that are valid and published since end of 2013,for a biliometric analysis.Results The number of articles published were increasing year by year;the most of the articles published in the developed southern areas;the number of articles in hospital internal management was the largest (384 articles,45.02%),followed those on external management and development situation and countermeasures (accounting for 27.43% and 22.39% respectively).Conclusion The increase of articles on private hospitals is connected with the support of national policy,the research of private hospitals is not in balance and its development environment is not favorable.

Objective To study the differential proteome of kidney between lupus nephritis mouse and normal mouse.Methods The proteins of kidney were separated by two-dimensional gel electrophoresis(2-DE).The gels stained by silver were scanned by ImageScanner and analyzed by PDQuest software.Results About 573?52 and 658?43 protein spots were found in the three maps of control group and LN group respectively;the match ratio was 83% and 87% respectively.One hundred and fourteen spots were found increased that showed a two fold increase as comparing to control group.Conclusion A significant difference in protein expression of LN mouse kidney was found and may be related to the pathogenesis of LN.

Objective To investigate the variation of immune index in patients with systemic lupus erythematosus (SLE) treated with autologous purified CD+34 cells transplantation and to clarify the relationship with pathogenesis and prognosis. Methods Flow cytometry (FCM) and enzyme linked immunosorbent assay(ELISA) were used to test lymphocyte subsets, C3, C4, CH50, autoantibodies and immunoglobulin for 18 cases of SLE before and after transplantation. Results The results showed that the ratio of all the T cell subsets reduced obviously in early postgraft and recovered gradually in 1 to 3 months after transplantation except CD45 RO+CD+4 cells. The levels of serum C3, C4, CH50 increased significantly after transplantation. No case relapsed within one year after transplantation, but 2 patients relapsed one year after transplantation. The levels of the indexes in the patients with relapse were significantly lower than those in the patients with persistent remission, including C4 in the entire course, CH50 in the 3rd and 12th month after transplantation and CD45 RA+ CD+8 cells in the 6th month after transplantation. However, the ratio of CD45 RO+ CD+4 cells in the first month after transplantation in the patients with relapse was higher than that in the patients with persistent remission. Conclusion Autologous purified CD+34 cells transplantation is effective for treating SLE. Survey of immune indexes before and after transplantation is important to investigate the pathogenesis of SLE. Moreover, these immune indexes can be used to predict therapeutic efficacy of SLE.

The pathological changes of systemic lupus erythematosus (SLE) could involve multiple organs and systems, showing a complicated and multivariate clinical features. Since the authors held that the previous clinical disease-syndrome integrative thought can not embody the regularity in the diagnosis and treatment of SLE, in order to establish a novel operable thought of syndrome differentiation which could reflect the clinical practice of SLE, they suggested, in accordance with their clinical experience, that the basis for integration of the disease and its syndromes should not be SLE itself but the clinical manifestations of the organs and systems, such as fever, nervous system injury, lupus kidney, thrombocytopenic purpura of SLE, etc. They claimed that the new clinical thought of diagnosis and treatment will contribute to conduct systematic and standard research on SLE, and the regulation of TCM therapy based on syndrome differentiation would be more closer to the clinical practice of SLE.
Diagnosis, Differential ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Lupus Erythematosus, Systemic ; diagnosis ; drug therapy ; Medicine, Chinese Traditional ; Phytotherapy ; Research Design