2.Research and Development on Immunotherapy of Alzheimer's Disease
Journal of Shanghai Jiaotong University(Medical Science) 2006;0(07):-
Alzheimer's disease(AD),the most common form of dementia,it is lack of effective cure or preventive treatment.Dementias in the elder are an increasing medical,social and economic problems and current treatments are only mildly effective.Recently,amyloid-beta protein(A?) has become a major therapeutic target.A? vaccine treatment can improve cognition in the patients with AD,but adverse events,such as meningencephalitis were observed in clinical study.The passive A? immunotherapy in humans is effective with possible safety.However,patients need to be monitored carefully.
3.The Importance of Properly Understanding SCI from the Perspective of Education for PhD Students in Medicine
Li-Ru WANG ; Bin SHI ; Jing LI ;
Chinese Journal of Medical Education Research 2006;0(10):-
Doctor's degree is the highest degree for medical education.Nowadays,medical doctor candidates in more and more medical universities are requested to publish research papers in intemational journals embodied in Science Citation Index(SCI),or they can not graduate with doctor's degree.So,it is significant for medical doctor candidates to learn the related knowledge about SCI and Impact Factor(IF).
4.Minimally invasive clinical pathway in patients after cardiac interventional therapy
Ru YANG ; Tong ZHOU ; Jiying YU ; Jing ZHANG
Chinese Journal of Practical Nursing 2008;24(13):8-10
Objective To explore the effect of minimally invasive clinical pathway in patients after car-diac interventional therapy. Methods One hundred and twenty patients who received cardiac interventional therapy from June 2005 to October 2006 were divided into the control group and the observation group.The control group received routine nursing while the observation group adopted minimally invasive clinical pathway of nursing.The nursing effect in the two groups was compared. Results The mean hospitalized duration, sat-isfaction degree and health knowledge level in the observation group were superior to those of the control group (P < 0.05). Conclusions The adoption of minimally invasive clinical pathway in patients after cardiac inter-ventional therapy could increase working efficiency nd ensure the nusing quality.
5.Effect of sport training on adrenal cortical hormones and gonadal axis hormones in serum of students.
Ru-xin PENG ; Wen-jing XU ; Shu-mao SHAO
Chinese Journal of Applied Physiology 2005;21(1):33-34
Adrenal Cortex Hormones
;
blood
;
Adult
;
Exercise
;
physiology
;
Gonadal Hormones
;
blood
;
Humans
;
Luteinizing Hormone
;
blood
;
Male
;
Pituitary-Adrenal System
;
Serum
;
metabolism
;
Students
;
Testosterone
;
blood
10.Effect of globular domain of adiponectin on glucose metabolism and insulin signal transduction in insulin resistant model adipocytes
Yan WANG ; Sisi CHEN ; Ru LIAN ; Xianjiu CHEN ; Jing YANG
Chinese Journal of Endocrinology and Metabolism 2012;(12):1016-1019
Insulin resistance model of 3T3-L1 adipocytes were prepared with plamotic acid.Adipocytes with generated insulin resistance were cultured with different concentrations of globular domain of adiponectin(gAd:250,500,1 000 ng/ml).The cell culture medium glucose content was detected with the glucose oxidase method,the mRNA expressions of insulin receptor substrate-1 (IRS-1),phosphatidylinositol-3 kinase(PI3K),and protein kinase B(PKB) were detected with real-time quantitative PCR method.The phosphorylation of IRS-1 was detected by Western blot.Compared with the control group,the experimental group showed significantly increased glucose consumption (P < 0.01),and with the increasing gAd concentration,glucose consumption was gradually increasing.IRS-1 phosphorylation was increased gradually with the increasing concentration of gAd.These results suggest that gAd can promote glucose uptake by 3T3-L1 adipocyte model with generated insulin resistance.This may be correlated with promoting insulin signal transduction and improving insulin resistance in adipocytes.