Objective To study the effect of music intervention through supra-aural earphone connected to MP3 on MAP, HR, RR and SpO2 of patients during cardiac interventional therapy.Methods 60 patients undergone cardiac intervention were randomly divided into control group (30cases) and experimental group (30 cases) according to operation time order. During the operation, traditional care was applied in control group and music intervention on the basis of traditional care was applied in experimental group. The changes of MAP, HR, RR and SpO2 and breathing mechanics were observed during four periods: 3 days before operation(T0), enter the operating room and anesthetic efficacy was definite and without music(T1), the first 11 min of operation (T2), and from the 11th min to the end of the operation (T3).Results In the control group, as compared to T0, MAP increased in T1, T2 and T3, the difference was statistically significant [the values were (105.7±10.8),(123.5±17.8),(125.1±18.5),(110.9±10.5)mm Hg, respectively, F=5.11, P＜0.05]. The values of HR and RR markedly increased in T1, T2 and T3 compared with T0 and the differences were statistically significant (P＜0.05). The values of MAP and HR also went up in T1 and T2 in experimental group, but the increase amplitude in T2 was obviously lower than that in T1 and that in control group, and the values in T3 nearly returned to the level in T0. Significant differences were found in MAP of T2 [(125.1±18.5)mm Hg vs (114.1±15.6)mm Hg,t=2.55,P＜0.05] and T3 as well(P＜0.05). Compared with themselves in each period, the values of SpO2 in the two groups had no significant differences(P>0.05). However, 3 patients' value of SpO2 decreased to 80% in control group on the account of tense breath holding. On the contrary, the respiration of patients in experimental group was much steadier. There was statistical difference between the two groups(χ2=2.73,P ＜0.05).Conclusions Application of music intervention in cardiac interventional therapy may degrade the stimulus of iatrogenic noise and maintain the equability of MAP, HR, RR and SpO2, and thus promote medical care quality.