Caliciviridae Infections ; epidemiology ; China ; epidemiology ; Diarrhea ; epidemiology ; virology ; Humans ; Norovirus ; Rotavirus ; Rotavirus Infections ; epidemiology

Asia ; epidemiology ; Genotype ; Humans ; Rotavirus ; classification ; genetics ; Rotavirus Infections ; epidemiology ; prevention & control ; virology ; Rotavirus Vaccines ; immunology

PURPOSE: This study was performed to investigate the epidemiological trend of rotavirus acute gastroenteritis (RV-AGE) in children. METHODS: A retrospective review was performed in patients (1 month to 18 years of age) with acute gastroenteritis at KEPCO Medical Center from September 2004 to August 2013. Comparative analyses were performed based on periods: pre-vaccine (2004-2006) and post-vaccine (2008-2012) in all patients; 2004-2006 (period A), 2007-2009 (period B) and 2010-2012 (period C) in patients under 5 years of age. RESULTS: Proportion of RV-AGE decreased from 25.0% (337/1,346) in pre-vaccine period to 20.8% (459/2,210) in post-vaccine period (rate ratio (RR), 0.83 [95% CI, 0.73-0.93]; P=0.0029). The median age of patients with RV-AGE in post-vaccine period (2.6 years) was significantly (P<0.0001) higher than that in pre-vaccine period (1.6 years). In patients hospitalized with AGE, proportion of RV-AGE was significantly reduced in patients 6 to 23 months old (RR, 0.62 [95% CI, 0.51-0.75]; P<0.0001). Significant decline in proportion of RV-AGE was observed in patients under 5 years of age: period A, 26.9% (308/1,144); period B, 22.7% (295/1,299); period C, 20.6% (186/902) (P=0.0007). After the introduction of rotavirus vaccine, a significant decreasing trend of RV-AGE proportion was observed in patients 6 to 11 months old (P=0.0018) and 12 to 23 months old (P=0.0152). CONCLUSION: Decrease in RV-AGE proportion and increase in age of patients with RV-AGE were observed after the introduction of rotavirus vaccine in this single center study. Continued and systematic surveillance is needed to assess the impact of rotavirus vaccine.
Child* ; Epidemiology ; Gastroenteritis* ; Humans ; Retrospective Studies* ; Rotavirus Infections ; Rotavirus Vaccines ; Rotavirus*

Child, Preschool ; China ; epidemiology ; Diarrhea ; epidemiology ; etiology ; virology ; Humans ; Infant ; Rotavirus ; Rotavirus Infections ; epidemiology

Child ; Child, Preschool ; China ; epidemiology ; Diarrhea ; epidemiology ; virology ; Humans ; Infant ; Molecular Epidemiology ; Rotavirus ; genetics ; Rotavirus Infections ; epidemiology ; virology

Adolescent ; Adult ; Aged ; China ; epidemiology ; Diarrhea ; epidemiology ; virology ; Female ; Humans ; Male ; Molecular Epidemiology ; Rotavirus ; genetics ; Rotavirus Infections ; epidemiology ; genetics

PURPOSE: There were a few reports for epidemiologic changes of rotavirus gastroenteritis during recent several years in Korea. We tried to know what is characteristics for the prevalence of rotavirus gastroenteritis in Jeju different from epidemiology of the other domestic area. METHODS: We performed a retrospective study of 211 patients with rotavirus gastroenteritis admitted to the pediatric ward at Cheju National University hospital, from December 2001 to June 2005. We defined as rotavirus infection that was positive on immunochromatography method applied to stool samples. RESULTS: Two hundred eleven patients with rotavirus gastroenteritis consisted of 13 patients in December 2001, 32 in 2002, 79 in 2003, 48 patients in 2004 and 39 in 2005 (until June). The monthly distributions, during 3 years from 2002 to 2004, were 40 patients (25.2%) in Jaunary, 56 (35.2%) in February, 31 (19.5%) in March and 23 (14.5%) in April. From May to December, there were only 9 patients (5.6%). Therefore, the prevalences of rotavirus gastroenteritis were concentrated on the 4 months (94.4%) including January, February, March and April. Also, the changes of the monthly distributions from January 2002 to June 2005 were not present. CONCLUSION: In recent years, the monthly distributions of rotavirus gastroenteritis in Jeju area were centered on the 4 months from January to April without prominent seasonal variation.
Epidemiology ; Gastroenteritis* ; Humans ; Immunochromatography ; Jeju-do ; Korea ; Prevalence ; Retrospective Studies ; Rotavirus Infections ; Rotavirus* ; Seasons

PURPOSE: This study was performed to assess the clinical and epidemiological changes after the introduction of the rotavirus vaccine in Korea, as well as to determine the efficacy of the rotavirus vaccine among hospitalized rotaviral gastroenteritis patients over the past two years. METHODS: We analyzed yearly and seasonal patterns of 1,165 inpatients who were hospitalized for rotaviral gastroenteritis under the age of 5 years between 2006 and 2013. We also conducted a survey among 460 gastroenteritis patients who were hospitalized between 2012 and 2013 regarding the rotavirus vaccination and the symptoms of gastroenteritis. Among those individuals surveyed, clinical indices were analyzed for 124 patients who were tested positive for the rotavirus antigen. RESULTS: The incidence of Rotaviral gastroenteritis have decreased significantly by year 2010. After the introduction and widespread dissemination of the rotavirus vaccine, the onset of the disease and the seasonal peak have been delayed. Overall, the vaccinated group showed a lower rate of positivity than the unvaccinated group. Among the hospitalized rotaviral gastroenteritis patients, the vaccinated group had a shorter hospitalization period, less severe clinical symptoms of gastroenteritis, and better laboratory test results. CONCLUSIONS: After introduction of the rotavirus vaccine in Korea, there were two main trends observed: 1) the overall level of disease incidence was reduced; 2) the severity of rotaviral gastroenteritis cases also decreased. Based on this data, more children should receive vaccination in order to prevent the rotavirus infection and decrease the severity of rotaviral gastroenteritis.
Child ; Epidemiologic Studies* ; Epidemiology ; Gastroenteritis* ; Hospitalization ; Humans ; Incidence ; Inpatients ; Korea ; Rotavirus Infections ; Rotavirus* ; Seasons ; Vaccination

China ; epidemiology ; Genes, Viral ; Humans ; Polymerase Chain Reaction ; methods ; Rotavirus ; genetics ; isolation & purification ; Rotavirus Infections ; epidemiology ; virology

OBJECTIVETo analyze the epidemiological and etiological characteristics of diarrheal disease among children under 5 years of age in Guangdong province, in 2012.

METHODS64 hospitals in 21 cities were chosen as the diarrheal syndromic surveillance sites, of which 14 hospitals were selected to carry out etiological surveillance among children under 5 years of age, including isolation and culture of both Vibrio cholera and Shigella as well as nucleic acid detection of rotavirus and norovirus by PCR. Descriptive method was used to analyze data from syndromic and etiological surveillance programs on diarrheal, from 1932 parents of the children.

RESULTSIn 2012, the outpatient attendance rate on diarrheal among children under 5 years was 0.8%. The proportion of diarrheal in children under 5-year-olds was 63.5%, among the total number of diarrheal outpatients at the outpatient clinics under surveillance program. The morbidity of infectious diarrhea was 1454.5/10 million in children under 5 years of age. A total number of 1932 specimens were collected from children under 5 years of age, in the outpatient department. Among these specimens,Vibrio cholera appeared all negative but one was Shigella positive and proved to be Sh. sonnei. The positive rates of rotavirus and norovirus were 14.1% (273/1932)and 16.9% (326/1932). Both rotavirus and norovirus were found in 24 specimens, with a positive rate as 1.2% . 112 specimens were successfully gene sequenced for rotavirus, of which 33.9% as G1[P8] genotype, 25.9% as G9[P8], 12.5% as G2[P4] and 9.8% as G3[P8] respectively. 90 specimens were successfully gene-sequenced for norovirus, of which 76.7% as G II.4 genotype. Genetic subtypes of G II. 4/2006b, accounted for 50.0% and could be detected around the year except for June and December. New G II. 4/Sydney Strain_2012 was first detected in August and became the predominant in December. In addition, 5 specimens belonged to G I genotype with other 16 subtypes of G II.

CONCLUSIONResults from our study proved that children under 5 years of age belonged to high-risk group for diarrheal disease in Guangdong province. Rotavirus and norovirus were both diverse in terms of genome.

Caliciviridae Infections ; epidemiology ; Child, Preschool ; China ; epidemiology ; Diarrhea ; epidemiology ; microbiology ; virology ; Female ; Genotype ; Humans ; Infant ; Male ; Rotavirus Infections ; epidemiology