In Islamic practice, the use of Qur’anic recitation in treatment can be traced back to thetimes of Prophet Muhammad (PBUH). This preliminary study aims to identify the potential of Qur’anicrecitation of Surah Al-Fatihah on the proliferation of chondrocytes derived from rabbit articular cartilage.Cartilage tissue engineering offers an alternative way to facilitate cartilage regeneration in-vitro. Materialsand Methods: The cellular model was established using a serially cultured and expanded chondrocytesin-vitro. The model was assigned into three groups. The first group was exposed to the Surah Al-Fatihah,recited 17 times based on the five times daily prayer unit (Raka’ah) obligated upon Muslims. The secondgroup was exposed to an Arabic poem recitation. The third group was not exposed to any sound and servedas the control. All groups were subjected to the growth profile analysis. The analysis was conducted atdifferent passages starting from passage 0 to passage 3. Results: The results showed that the cellsproliferation based on the growth kinetic analysis is higher for the cells exposed with Qur’anic recitation ascompared to the Arabic poem and control groups. Conclusions: The proliferation process of the rabbitarticular cartilage might be influenced with the use of Qur’anic recitation and as well as Arabic poemrecitation. Exposure to the Western poem recitation and mute sound will be added for future study. It ishoped that this study could shed some light on the potential use of the Qur’anic recitation to facilitatecartilage regeneration in tissue engineering studies.