1.Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration.
Maria Antonietta PANARO ; Alessandra ALOISI ; Giuseppe NICOLARDI ; Dario Domenico LOFRUMENTO ; Francesco DE NUCCIO ; Velia LA PESA ; Antonia CIANCIULLI ; Rosaria RINALDI ; Rosa CALVELLO ; Vania FONTANI ; Salvatore RINALDI
Neuroscience Bulletin 2018;34(2):270-282
In this study, the effects of Radio Electric Asymmetric Conveyer (REAC), a non-invasive physical treatment, on neuroinflammatory responses in a mouse model of parkinsonism induced by intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), were investigated in vivo. We found that the REAC tissue optimization treatment specific for neuro-regenerative purposes (REAC TO-RGN-N) attenuated the inflammatory picture evoked by MPTP-induced nigro-striatal damage in mice, decreasing the levels of pro-inflammatory molecules and increasing anti-inflammatory mediators. Besides, there was a significant reduction of both astrocyte and microglial activation in MPTP-treated mice exposed to REAC TO-RGN-N. These results indicated that REAC TO-RGN-N treatment modulates the pro-inflammatory responses and reduces neuronal damage in MPTP-induced parkinsonism.
Animals
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Corpus Striatum
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pathology
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Electric Stimulation
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methods
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Inflammation
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pathology
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Male
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Mice
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Nerve Degeneration
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pathology
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Nerve Regeneration
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physiology
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Parkinsonian Disorders
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pathology