REarranged during Transfection (RET) gene encodes a receptor tyrosine kinase and it was initially discovered as an in vitro transforming gene. For many years, RET has been involved in papillary thyroid carcinoma and medullary thyroid carcinoma. More recently, lung adenocarcinoma and chronic myelomonocytic leukemia samples have been found to display RET gene rearrangements. This knowledge is stimulating the search for protein kinase inhibitors to combat RET-driven malignancies.
Adenocarcinoma ; Carcinoma ; Gene Rearrangement ; Humans ; Leukemia, Myelomonocytic, Chronic ; Lung ; Lung Neoplasms ; Oncogenes ; Phosphotransferases ; Protein Kinase Inhibitors ; Protein-Tyrosine Kinases ; Signal Transduction ; Thyroid Gland ; Thyroid Neoplasms ; Transfection