Objective To study the distribution and drug resistance of pathogens in neonatal septicemia in order to provide clinical guidance for antibiotic usage.Methods This retrospective study analyzed blood culture and clinical data from 83 confirmed neonatal septicemia patients and the blood collection cultures were analyzed.Results A total of 84 strains were isolated from 83 cases of blood specimens,Gram positive bacteria,Gram negative bacteria and fungi were 38(45.2%),41(48.8%),5(6.0%),respectively.Gram positive bacteria was mainly coagulase negative staphylococcus and staphylococcus aureus,which were 13(15.5%) and 8(9.5%) respectively.Gram negative bacteria was mainly Escherichia coli and Klebsiella pneumonia,which were 25(29.8%) and 9(10.7%) respectively.Gram positive bacteria were found high resistance to penicillin G,amoxicillin clavulanate potassium,oxacillin and clindamycin,from 34.2% to 73.7%,but they were sensitive to vancomycin,teicoplanin and linezolid.Gram negative bacteria were found high resistance to ampicillin(82.9%),the constituent ratio of the extended spectrum βlactamases(ESBLs) was 34.1%,carbapenem resistant strains was not found.All fungi were sensitive to azoles.Conclusion Gram negative bacteria are the major pathogens in neonatal septicemia,with high infection rate of Escherichia coli and high constituent ratio of the ESBLs,and antimicrobial agents should be chosen according to blood culture and antimicrobial susceptibility results.

Objective:To characterize the volatile compounds in 10 batches of disposable infusion sets and 6 batches of nasal can-nulas by GC-MS and determine the main odor-active compounds. Methods:The volatile components were extracted using a headspace sampler. An HP-5MS capillary column (30 m × 0. 25 mm,0. 25 μm) was adopted, and the qualitative analysis was performed by total ion chromatography ( TIC) of full scan with temperature programmer. Results:A total of 19 major volatile compounds were identified, which were hydrocarbon, alcohol and carbonyl compounds (such as aldehyde and ester). Based on the combination of odor test and GC-MS, the concentration of alcohol compounds (2-ethyl hexanol, 2-EH) had the most notable effect on the odor of samples. Conclu-sion:The samples with unacceptable order contain 2-EH with relatively high content, which should be paid more attention.

Objective To study the value of ultrasound in operation for traumatic brain injury (TBI) in simulation field hospitals where computed tomography (CT) equipment is unavailable.Methods The wartime conditions were simulated, and the patients at age of 18-60 years were randomly selected.According to the principles of medical ethics, all patients received CT scanning.Two neurosur-geons from the field hospital who did not know the result of CT examination cooperated with another two neurosurgeons who got the results of the CT examination to determine whether operation should be ap-plied.Forty-five patients who needed emergency craniotomy were finally selected.The operations were performed by two neurosurgeons from the field hospital, with real-time ultrasound monitoring.The results of ultrasound were compared with that of CT scanning.Results A total of 64 lesions were found by ul-trasound , and 60 of which should be treated by operation.In the meantime, 82 lesions were found by CT scanning, 64 of which should be treated operatively.Epidural hematoma and subdural hematoma had high ultrasound detection rate, followed by intracerebral hematoma, subdural effusion and brain contusion.The overall detection rate of ultrasound was 87.1%.Conclusion Ultrasound plays an important role in correctly finding the focus so as to reduce blind operation and avoid omission of the focus in field hospi-tals, where CT equipment is usually unavailable.

Objective To investigate the risk factors for postoperative numbness syndrome sec-ondary to lumbar disc herniation(LDH)based on propensity score matching(PSM).Methods A retrospective analysis was conducted on the clinical data of 429 LDH patients who underwent surgical treatment.The patients were divided into numbness syndrome group(85 patients)and non-numbness syndrome group(344 patients)according to whether they developed postoperative numbness syn-drome.A 1∶1 match was performed between the numbness syndrome group and the non-numbness syndrome group based on PSM,with 67 patients in each group after matching.The clinical data of the two groups before and after matching were compared,and Cox regression analysis was performed on the matched data to screen risk factors for postoperative numbness syndrome secondary to LDH.Re-sults The incidence of postoperative numbness syndrome in LDH patients was 19.81％(85/429).Be-fore matching,the numbness syndrome group had a higher or longer proportion of males,age,body mass index(BMI),duration of disease,proportion of patients with L3 to L4 or L4 to L5 lesion segments,proportion of patients with grade Ⅳ to Ⅴ disc degeneration,proportion of patients with prolapsed or free-fragment herniation,operation time,proportion of patients with incomplete nucleus pulposus re-moval during surgery,proportion of patients with annulus fibrosus rupture,proportion of patients with a history of hyperlipidemia,proportion of patients who did not undergo postoperative rehabilita-tion exercises,and postoperative activity intensity scores compared to the non-numbness syndrome group(P＜0.05).After matching,the numbness syndrome group had higher or longer age,BMI,duration of disease,proportion of patients with grade Ⅳ to Ⅴ disc degeneration,proportion of pa-tients with prolapsed or free-fragment herniation,proportion of patients with incomplete nucleus pul-posus removal during surgery,proportion of patients with annulus fibrosus rupture,proportion of pa-tients with a history of diabetes,proportion of patients who did not undergo postoperative rehabilita-tion exercises,and postoperative activity intensity scores compared to the non-numbness syndrome group(P＜0.05).The results of multivariate Cox regression analysis showed that high BMI,gradeⅣ to Ⅴ disc degeneration,incomplete nucleus pulposus removal during surgery,annulus fibrosus rupture,history of diabetes,lack of postoperative rehabilitation exercises,and high postoperative activity intensity were independent risk factors for postoperative numbness syndrome secondary to LDH(HR=4.395,7.183,4.404,5.633,3.521,4.929,3.710,P＜0.05).Conclusion Af-ter controlling for confounding factors based on PSM,the risk factors for postoperative numbness syn-drome secondary to LDH include high BMI,grade Ⅳ to Ⅴ disc degeneration,incomplete nucleus pulposus removal during surgery,annulus fibrosus rupture,a history of diabetes,lack of postopera-tive rehabilitation exercises,and high postoperative activity intensity,which is helpful for clinical healthcare professionals to early identify high-risk patients with postoperative numbness syndrome secondary to LDH and provide a reference for subsequent patient treatment.

Objective To investigate the risk factors for postoperative numbness syndrome sec-ondary to lumbar disc herniation(LDH)based on propensity score matching(PSM).Methods A retrospective analysis was conducted on the clinical data of 429 LDH patients who underwent surgical treatment.The patients were divided into numbness syndrome group(85 patients)and non-numbness syndrome group(344 patients)according to whether they developed postoperative numbness syn-drome.A 1∶1 match was performed between the numbness syndrome group and the non-numbness syndrome group based on PSM,with 67 patients in each group after matching.The clinical data of the two groups before and after matching were compared,and Cox regression analysis was performed on the matched data to screen risk factors for postoperative numbness syndrome secondary to LDH.Re-sults The incidence of postoperative numbness syndrome in LDH patients was 19.81％(85/429).Be-fore matching,the numbness syndrome group had a higher or longer proportion of males,age,body mass index(BMI),duration of disease,proportion of patients with L3 to L4 or L4 to L5 lesion segments,proportion of patients with grade Ⅳ to Ⅴ disc degeneration,proportion of patients with prolapsed or free-fragment herniation,operation time,proportion of patients with incomplete nucleus pulposus re-moval during surgery,proportion of patients with annulus fibrosus rupture,proportion of patients with a history of hyperlipidemia,proportion of patients who did not undergo postoperative rehabilita-tion exercises,and postoperative activity intensity scores compared to the non-numbness syndrome group(P＜0.05).After matching,the numbness syndrome group had higher or longer age,BMI,duration of disease,proportion of patients with grade Ⅳ to Ⅴ disc degeneration,proportion of pa-tients with prolapsed or free-fragment herniation,proportion of patients with incomplete nucleus pul-posus removal during surgery,proportion of patients with annulus fibrosus rupture,proportion of pa-tients with a history of diabetes,proportion of patients who did not undergo postoperative rehabilita-tion exercises,and postoperative activity intensity scores compared to the non-numbness syndrome group(P＜0.05).The results of multivariate Cox regression analysis showed that high BMI,gradeⅣ to Ⅴ disc degeneration,incomplete nucleus pulposus removal during surgery,annulus fibrosus rupture,history of diabetes,lack of postoperative rehabilitation exercises,and high postoperative activity intensity were independent risk factors for postoperative numbness syndrome secondary to LDH(HR=4.395,7.183,4.404,5.633,3.521,4.929,3.710,P＜0.05).Conclusion Af-ter controlling for confounding factors based on PSM,the risk factors for postoperative numbness syn-drome secondary to LDH include high BMI,grade Ⅳ to Ⅴ disc degeneration,incomplete nucleus pulposus removal during surgery,annulus fibrosus rupture,a history of diabetes,lack of postopera-tive rehabilitation exercises,and high postoperative activity intensity,which is helpful for clinical healthcare professionals to early identify high-risk patients with postoperative numbness syndrome secondary to LDH and provide a reference for subsequent patient treatment.