1.Clinical practice and training for students majoring in optometry and ophthalmology
Rongrong LE ; Jing ZHUGE ; Fan LV ; Jia QU
Chinese Journal of Medical Education Research 2013;(10):1037-1039
To improve the clinical skills of medical students and to train qualified and profes-sional ophthalmologist,the school of optometry and ophthalmology in Wenzhou Medical College car-ried out reforms and innovations in clinical practice and training. In order to strengthen and train clin-ical thinking and clinical skills,and to cultivate the humanistic qualities of medical students,the di-verse-training mode were applied in clinical practice and training. In this paper explored the design goal, objective and actual effect of diverse-training mode for clinical practice and training.
2.Choice of the treatment of palliative therapy of jaundice in cholangiocarcinom
Chong WANG ; Anyi QIAO ; Zhu LI ; Rongrong QU ; Jinghao HUANG
International Journal of Surgery 2014;41(8):528-533
Objective To compare the efficacy and indications between the biliary bypass laparotomy surgery.and the two different kinds of biliary stent insertion surgery in the palliative alleviating jaundice of cholangiocarcinoma.Methods From March 2008 to March 2013,69 patients treated with palliative alleviating jaundice therapy of cholangiocarcinoma were included,who were all came from the Third Affiliated Hospital of Guangzhou Medical University.Including 17 patients who treated with the open biliary bypass surgery and 52 patients who treated with interventional therapy.We analysed the differences between these cases of biliary drainage operations in the recent jaundice reduction rate,average stay,mortality rate,the incidence of related complications,et al.Results All these different drainage ways had good effect in alleviating jaundice,incidence of alleviating jaundice have no obvious difference (P > 0.05).Compared to the open biliary bypass surgery,interventional therapy had obvious advantages in the average stay and postoperative survival (P < 0.05).The pancreatitis rate was lower in Percutaneous Group than that in Endoscopic Group (P < 0.05).incidence of biliary tract infection and biliary tract bleeding have no obvious difference (P > 0.05).There were no significant differences between the success rates of in biliary stent insertion operation in patients with each model cholangiocarcinoma (P > 0.05).Conclusions Among the therapies of the palliative alleviating jaundice of cholangiocarcinoma,the internal biliary drainage of biliary stent insertion operation was superior to the treatment of the biliary bypass laparotomy.As to biliary stent insertion operations,endoscopic biliary stenting surgery should be the preferred choice.
3. The application of failure mode and effect analysis to improve the hand hygiene compliance of medical staff in eye hospital
Chinese Journal of Industrial Hygiene and Occupational Diseases 2018;36(6):448-451
Objective:
To discuss the application of failure mode and effect analysis to improve the hand hygiene compliance of medical staff in eye hospital.
Methods:
To form failure mode and effect analysis (FMEA) quality control team. By using FMEA method of risk management, to analyze the risk factors of hand hygiene compliance of medical staff in eye hospital. By performing analysis, to determine the high risk factors, develop and implement the improvement measures to reduce the risk of these factors.
Results:
the awareness rate of hand hygiene knowledge was increased significantly after the implementation of failure mode and effect analysis (
4.Effects of orexin A on morphine-induced gastrointestinal dysfunction in mice
Junmei ZHANG ; Chuanqi YANG ; Shanshan QU ; Rongrong HUANG ; Shaoli DING ; Kaihua YU ; Yulan LI
Chinese Journal of Anesthesiology 2022;42(11):1324-1328
Objective:To evaluate the effect of orexin A on morphine-induced gastrointestinal dysfunction in mice.Methods:Forty SPF C57B/6 mice, aged 6-8 weeks, half male and half female, weighing 18-22 g, were divided into 5 groups ( n=8 each) using a random number table method: control group (group C), morphine group (group M) and morphine + different doses of orexin A groups (MOH, MOM and MOL groups). Normal saline 8 ml/kg was subcutaneously injected daily in group C, morphine 6 mg/kg was subcutaneously injected daily in the other four groups, and orexin A 75, 50 and 25 μg/kg were subcutaneously injected daily for 10 days at the same time in MOH, MOM and MOL groups.The fetal water content was calculated and averaged daily.After the last administration, the mice were gavaged with black nutrient paste, and the gastric emptying rate and small intestinal propulsion rate were detected 30 min later.Blood samples were collected from the orbit, and the concentration of serum gastrin (GAS) was detected by enzyme-linked immunosorbent assay.The mice were then sacrificed, and colon tissues were removed for determination of c-kit positive cell area (by immunohistochemistry) and expression of c-kit, substance P (SP) and neural nitric oxide synthase (nNOS) in colon tissues (by Western blot). Results:Compared with group C, the rate of fecal water content, gastric emptying rate, small intestinal propulsion rate and serum GAS concentration were significantly decreased, the area of c-kit positive cells was decreased, and the expression of c-kit and SP was down-regulated, and the expression of nNOS was up-regulated in group M ( P<0.05). Compared with group M, the small intestinal propulsive rate and serum GAS concentration were significantly increased, and the area of c-kit positive cells was increased, and the expression of c-kit was up-regulated in group MOH, the rate of fecal water content, gastric emptying rate, small intestinal propulsion rate and serum GAS concentration were significantly increased, the area of c-kit positive cells was increased, and the expression of c-kit and SP was up-regulated, and the expression of nNOS was down-regulated in group MOM, and the serum GAS concentration and c-kit positive cell area were significantly increased in group MOL ( P<0.05). Conclusions:Orexin A 50 μg/kg can effectively alleviate the gastrointestinal dysfunction induced by morphine in mice, and the mechanism may be related to promotion of GAS secretion, interstitial cells of Cajal growth and SP release and inhibition of NO release.
5.Discussion on application of mean gamma index to Compass 3D dose verification in target area receiving 50% of prescribed dose
Qianqian ZHENG ; Jing CAO ; Rongrong QU ; Wenchao GAO ; Wenzhang CHEN
Chinese Journal of Radiological Medicine and Protection 2023;43(6):469-474
Objective:To explore the value of using the mean gamma index (GI) in targer area receiving 50% prescribed dose as reference in VMAT planned dose verification through model-based dose calculation and measurement-based dose reconstruction.Methods:Based on Compass dose verificantion system, the VMAT plans for 70 patients were validated using two method. The mean GI and passing rate in target area receiving 50% of prescribed dose area for each validation plan were obtained to evaluate its application value in dose validation. First, plan information obtained by TPS calculation was input into the Compass system for performing independent dose calculation based on the accelerator data model, and obtain a three-dimensional dose based on the independent model calculation. The planned fluence measured for each patient′s treatment plan on the accelerator was reconstructed through the Compass system to obtain a three-dimensional dose based on measurement reconstruction. The three-dimensional dose obtained by the two method were compared with the three-dimensional dose calculated by TPS.Results:Combined with the gamma criteria of 3%/3 mm in the error setting condition of GI analysis, the mean GI in the area receiving 50% of prescribed dose was evaluated. GI≤0.4 was classified as PASS, 0.4 < GI ≤ 0.6 as being clinically acceptable, and GI > 0.6 as FAIL. The VMAT planned dose verification for 70 patients showed that the model-based independent calculation was in a better agreement with the TPS calculation. The GI values were all < 0.6: GI≤0.4 for 67 patients and 0.4
6.Relationship between maternal exposure factors and small for gestational age infant
Rongrong JIN ; Juanjuan LI ; Yimin QU ; Liangkun MA ; Yu JIANG
Chinese Journal of Epidemiology 2016;37(9):1306-1310
Through literature study,this paper summarizes the current status ofreseareh on the relationship between maternal exposure factors and small for gestational age infant both in China and abroad.And at the same time,the relationship between pregnancy outcome of small for gestational age and maternal exposure factors was analyzed.This might contribute to reduce the incidence of small for gestational age infant and provide important guidance and references for perinatal care.
7.Relationship between pesticide exposure and adverse pregnancy outcomes among reproductive couples in rural areas of China
Yimin QU ; Shi CHEN ; Juanjuan LI ; Rongrong JIN ; Hui PAN ; Yu JIANG
Chinese Journal of Epidemiology 2017;38(6):732-736
Objective To analyze the association between pesticide exposure and adverse pregnancy outcomes in women from the rural areas of China.Methods Data of "National Free Preconception Health Examination Project (NFPHEP)" from January 2010 to December 2012 was used for analysis.A total of 248 501 families that were planning to deliver a baby in the next 6 months were enrolled.Data on paternal exposure to pesticides before or during pregnancy was collected through questionnaires,with related outcomes on pregnancy recorded by doctors.Results Among all the 248 501 participants,1 806 (0.74%) women and 2 653 (1.09%) men reported to have been exposed to pesticide before pregnancy,with 505 (0.21%) reported of having been exposed to pesticide during the period of pregnancy.Maternal exposure to pesticide was found a risk factor related to stillbirth (OR=3.37,95 % CI:2.05-5.55),peculiar smell pregnancy (OR =3.17,95%CI:1.18-8.55) and low birth weight (OR=7.56,95% CI:5.36-10.66).Paternal exposure to pesticide was also found related to miscarriage (OR=1.37,95% CI:1.03-1.80),low birth weight (OR=3.65,95% CI:1.51-8.84),or giant infant (OR?=0.64,95% CI:0.44-0.93).Maternal exposure to pesticide during pregnancy appeared a risk factor on miscarriage (OR=4.65,95% CI:3.47-6.24).Other adverse outcomes on pregnancy would include premature birth and high birth weight.Conclusion Parental pesticide exposure appeared a risk factor on stillbirth,peculiar smell pregnancy,low birth weight and miscarriage.
8.Current status of folic acid supplementation in women at child-bearing age in suburban area of Beijing
Rongrong JIN ; Yimin QU ; Juanjuan LI ; Shuai MA ; Liangkun MA ; Yu JIANG
Chinese Journal of Epidemiology 2017;38(10):1347-1351
Objective To access the current status of folic acid supplementation in women at childbearing age in suburban area of Beijing,2016.Methods In this cross-sectional study,a total of 722 women aged 17-41 years from six hospitals in suburban areas of Beijing were selected through cluster sampling.A questionnaire survey was conducted.Results The rates of folic acid intake and regular folic acid intake among women under survey were 63.9% (456/714) and 83.3% (380/456).In women who remembered the duration of folic acid supplementation,the overall rate of preconceptional folic acid supplementation was 35.5% (159/450),in whom 27.3% (123/450) began to take folic acid 0-3 months before pregnancy;8.0% (36/450) began to take folic acid 3 months before pregnancy.Multivariate logistic regression analysis indicated that household registering type,preparation for pregnancy or pregnancy,parity,smoking and alcohol use were the influencing factors for folic acid supplementation.Conclusions The rate of folic acid supplementation remained low in childbearing aged women in suburban area of Beijing.It is necessary to further strengthen the health education about the importance of folic acid supplementation to improve the intake rate and the regular intake rate of folic acid in pregnant women and to promote maternal infant health and reduce the related complications.
9.Impact of hyperoxia on the phenotype of pulmonary artery smooth muscle cells
Shanshan QU ; Yulan LI ; Rongrong HUANG ; Hong GUO ; Xiumei WANG ; Junmei ZHANG ; Chuanqi YANG
Chinese Journal of Cardiology 2024;52(2):185-190
Objective:To investigate the influence of varied oxygen (O 2) concentration environments on the phenotypic transformation of pulmonary artery smooth muscle cells (PASMC) and the mechanism of pulmonary hypertension. Methods:Primary rat PASMC were isolated and cultured through the process of enzymatic digestion. Following identification, the stable passaged PASMC were subjected to a 6-hour incubation in sealed containers with normal O 2 content (group C) and relative O 2 content comprising 55% (group H55), 75% (group H75), and 95% (group H95). mRNA and protein expression of α-Actin (α-SMA), smooth muscle 22α (SM22α), osteopontin (OPN), and matrix metalloproteinase-2 (MMP-2) were measured using real-time quantitative PCR and western blot analysis. Results:The H55 group displayed no significant difference from the C group in terms of mRNA and relative protein expression levels for α-SMA, SM22α, OPN, and MMP-2 (all P>0.05). On the other hand, groups H75 and H95 exhibited a reduction in mRNA and relative protein expression of α-SMA and SM22α, along with an increase in mRNA and relative protein expression of OPN and MMP-2 when compared with both the C and H55 groups (all P<0.05). The H95 group showed a higher relative mRNA expression of MMP-2 as compared to the H75 group ( P<0.05). Conclusions:Oxygen concentration environments of 75% or higher can serve as the foundation for the pathogenesis of pulmonary hypertension, essentially by inducing a phenotypic transformation in PASMC towards adopting a robust secretory function. This induction is contingent upon the concentration of oxygen present.
10.Status of psychological resilience of ophthalmic hospital Operating Room nurses and its correlation with career development
Qiutao JIN ; Rongrong QU ; Xiangfan JIA ; Zhiyu MA ; Wei LIN
Chinese Journal of Modern Nursing 2023;29(17):2339-2341
Objective:To investigate the status and influencing factors of psychological resilience of ophthalmic hospital Operating Room nurses, and to explore the correlation between psychological resilience and career development of Operating Room nurses.Methods:This is a cross-sectional study. From October to December 2021, 40 Operating Room nurses from Eye Hospital of Wenzhou Medical University were selected by convenience sampling method and investigated using general information questionnaire, Connor-Davidsion Resilience Scale (CD-RISC) and Career Development Questionnaire. Univariate analysis was used to explore the influencing factors of psychological resilience of Operating Room nurses. Pearson correlation analysis was employed to explore the correlation between psychological resilience and career development. A total of 40 questionnaires were distributed in this study, and 40 valid questionnaires were recovered, with an effective recovery rate of 100.0%.Results:The CD-RISC score of the Operating Room nurses was (90.40±9.27) , the score of Career Development Questionnaire was (112.5±9.65) . Univariate analysis results showed that age, professional title and working years were the influencing factors of psychological resilience of ophthalmic hospital Operating Room nurses ( P<0.01) . Pearson correlation analysis results showed that psychological resilience of Operating Room nurses was positively correlated with career development ( r=0.762, P<0.05) . Conclusions:The psychological resilience of ophthalmic hospital Operating Room nurses is at a medium level, and age, professional title and working years are its influencing factors. Operating Room nurses with high psychological resilience have better career development. Nursing managers should formulate personalized study and career plans, so as to promote nurses ' career development.