1.Comparative analysis on the performance evaluation of hospitals between China and some countries
Rongqin JIANG ; Jingxian LI ; Dan HU ; Aichen GE ; Jiaying CHEN
Chinese Journal of Health Policy 2016;9(12):62-67
This study aimed at comparing the United States, Britain, Australia, the Netherlands and China’s national performance evaluation, and sum up the experience to provide a theoretical basis for the China’s development of hospital performance evaluation system. The study found that China needs to consider the patient's perspective, to establish a fixed third-party performance evaluation agencies, establish an effective incentive mechanism and feedback mechanism and combine a variety of assessment methods in the development of hospital performance evaluation index system.
2.Bioavailability Evaluation of Sustained-Release Metformin Formulation After Single and Multiple Oral Dosing in Healthy Volunteers
Yanyan JIANG ; Rongqin HUANG ; Lingmei ZHENG ; Yuanying PEI
Fudan University Journal of Medical Sciences 2005;32(2):178-181
Purpose To evaluate the relative bioavailability of a domestic sustained-release metformin tablets (SRM) compared against an immediate-release metformin tablets (IRM) using a multiple-dose,two-way crossover design after a single-dose study. Methods Eighteen healthy adult male volunteers,aged 18 to 22 years (mean,20 years),weighing 55 to 76 kg (mean,64 kg) and with height ranging from 166 to 180 cm (mean,173 cm),and blood glucose levels from 4.0 to 5.9 mmol/L (mean,4.3 mmol/L) participated in the study.The concentrations of metformin in plasma were determined using a ion-pair liquid chromatographic method. Results In single-dose study,the mean residence time (MRT),Tmax,and apparent elimination half-life (T1/2) for SRM were significantly longer and Cmax significantly lower than the corresponding values determined for IRM.The similar results were also demonstrated in multiple-dose study.The mean values of the relative bioavaibility of SRM compared with IRM in two administration ways were (85.95±0.97)% and (86.44±7.88)%,respectively.The single-dose and multiple-dose administration of the 90% confidence interval for the ratio of the logarithmic transformed AUC values of SRM over those of IRM were calculated to lie between 0.83 and 0.88,0.83 and 0.89,respectively,being within the acceptable bioequivalence limit of 0.80~1.25. Conclusion SRM was of the characteristic of sustained-release pharmacokinetics.The relative bioavailability for single dosing was similar to that of multiple dosing,and both of the administration ways demonstrated bioequivalence in absorption between SRM and IRM.
3.Preparation of folate-NOTA-Al18F targeting folate receptor and its microPET/CT imaging
Zele CHEN ; Jilin YIN ; Cheng WANG ; Xinlu WANG ; Lisha JIANG ; Rongqin ZHANG
Chinese Journal of Nuclear Medicine and Molecular Imaging 2017;37(8):482-485
Objective To prepare PET molecular probe folate-NOTA-Al18F(18F-FNA) and to explore its feasibility as an imaging agent in folate receptor positive KB tumor.Methods 18F-FNA was prepared by the method of aluminum fluoride coordination labeling, and the effect of phase transfer catalyst K2.2.2 on the labeling yield was evaluated.Biological distribution was carried out at 10, 30 and 90 min after injection of 3.7 MBq 18F-FNA in nude mice (n=20) xenografted with KB tumor, and the radioactive uptake (%ID/g) and T/NT ratios were then calculated in different organs or tissues.MicroPET imaging was performed at 40 min after injection of 18F-FNA (3.7 MBq).Results The labeling yield of 18F-FNA increased with the presence of K2.2.2.The radiochemical yield was above 98%.The radiochemical purity was above 99%, and still above 98% after maintained in PBS and FBS at 37 ℃ for 4 h.The biodistribution showed that the blood clearance of the probe was slow, and the uptakes in kidneys and tumor which overexpressed folate receptor were significantly high ((5.12±0.58) %ID/g and (1.37±0.20) %ID/g).The high radioactive uptake was observed in KB xenografted mice using microPET imaging.Conclusions The labeling yield of 18F-FNA could increase with the presence of K2.2.2.Furthermore, the encouraging biological distribution and microPET imaging results indicate that 18F-FNA may be a candidate for PET imaging in targeting folate receptor.
4.Development of a hospital performance scale based on patient experience
Dan HU ; Xuanxuan WANG ; Ya ZHU ; Rongqin JIANG ; Jingxian LI ; Aichen GE ; Jiaying CHEN
Chinese Journal of Hospital Administration 2017;33(6):463-466
The paper described the development stages of a hospital performance evaluation scale based on patient experience.An empirical application on 7 856 patients of 26 hospitals in four provinces in the country identified the challenges encountered in the course of its application.These include limits of patients experience,variations on the experience reports incurred by different services experienced by patients,and setting of the patient-inpatient ratio among others.Solutions proposed based on these studies aim at creating a patient experience scale tailored to Chinese patients.
5.A study of diagnostic criteria for traditional Chinese medicine syndromes in osteoporosis.
Dongtao LI ; Fuyu LI ; Jian WANG ; Jihong LIU ; Nan YAN ; Yongmei CHENG ; Aihua HU ; Hongyang JIANG ; Fenglei SHI ; Meizeng ZHANG ; Jie LI ; Lingbo WEI ; Rongqin JIANG
Journal of Integrative Medicine 2011;9(12):1326-32
To establish diagnostic criteria for common traditional Chinese medicine (TCM) syndromes in osteoporosis.
6.Quantitative evaluation of the degrees of traditional Chinese medicine qualitative syndromes of osteoporosis.
Dongtao LI ; Jian WANG ; Hongyang JIANG ; Fenglei SHI ; Fuyu LI ; Jihong LIU ; Yongmei CHENG ; Nan YAN ; Aihua HU ; Meizeng ZHANG ; Jie LI ; Lingbo WEI ; Rongqin JIANG
Journal of Integrative Medicine 2012;10(11):1254-62
To establish a quantitative estimate model for diagnosing traditional Chinese medicine (TCM) syndromes of patients with osteoporosis.
7.Quantitative evaluation of the degrees of qualitative syndromes commonly encountered in patients with coronary heart disease.
Dongtao LI ; Jie LI ; Jian WANG ; Fuyu LI ; Jingxiu ZHU ; Meizeng ZHANG ; Junyan LI ; Yanlai XU ; Lingbo WEI ; Wenyan JI ; Rongqin JIANG ; Xuefa LIU
Journal of Integrative Medicine 2010;8(8):750-6
Objective: To establish a quantitative model for evaluating the degree of traditional Chinese medicine (TCM) syndromes often seen in patients with coronary heart disease (CHD). Methods: Medical literature concerning clinical investigation of TCM syndromes of CHD was collected and organized, and the "Hall for Workshop of Metasynthetic Engineering" expert symposium method was applied. First, the 100 millimeter scaling was used for combining with scoring on degree of symptoms to establish a quantitative criterion for classification of symptom degree in CHD patients, and the model was established by using comprehensive analytic hierarchy process as the mathematical tool to estimate the weight of the criterion for evaluating qualitative syndromes in various layers by specialists. Then the model was verified in clinical practice and the outcomes were compared with fuzzy evaluation from the specialists. Results: A total of 287 clinical observation forms on CHD cases were collected, and 167 forms were available after excluding any irregular forms. The results showed that basic coincidence rate between the outcomes derived from specialists and those from the model was 68.26% (114/167), and part coincidence rate was 88.62%(148/167). Conclusion: This model, with good rationality and feasibility, has a high coincidence rate with fuzzy evaluation from specialists, and can be promoted in clinical practice. It is a good quantitative model for evaluating the degree of TCM syndromes of CHD.