OBJECTIVE:To systematically evaluate the efficacy and safety of modified infusion(2-4 h infusion or continuous 24 h infusion)versus traditional infusion(0.5-1 h infusion)of meropenem in the treatment of severe infectious,and to provide evi-dence-based reference for clinic treatment. METHODS:Retrieved from Medline,CJFD,VIP database and Wanfang database, modified infusion(test group)versus traditional infusion(control group)of meropenem in the treatment of severe infections were collected,and Mata-analysis was performed by using Rev Man 5.0 statistical software after extracting data and evaluating quality. RESULTS:A total of 13 studies were included,involving 1 012 patients. Results of Meta-analysis showed the effective rate [RR=1.25,95%CI(1.10,1.43),P<0.001] and bacterial eradication rate [RR=1.25,95%CI(1.05,1.48),P=0.01] in test groups were sig-nificantly higher than those of control group,and there were no significant differences in the mortality rate [RR=0.74,95%CI (0.46,1.18),P=0.21] and incidence of adverse reactions [RR=0.81,95%CI(0.48,1.39),P=0.45]. CONCLUSIONS:Compared with traditional infusion of meropenem,extended or continuous infusion can improve efficacy in the treatment of severe infections, with similar safety. Due to methodology limit of included studies,large-scale and high quality RCT are required for further valida-tion of the conclusions.

Objective To observe the clinical effects of therapy to neonatal jaundice by Yinzhihuang particles.Methods72 cases from July 2015 to December 2016, were randomly divided into two groups and made all 36 cases in the control group, children in the control group given blue light therapy observation group were treated in the control group on the basis of Yinzhihuang particle therapy, follow-up and record two serum C-reactive protein (CRP), total bilirubin (TBIL), γ-alanine amino acyltransferase (γ-GT), alkaline phosphatase (AKP) and free fatty acid (FFA) levels and incidence of adverse reactions, the use ofstatistical methods for data analysis.Results① observation group after treatment CRP,TBIL, γ-GT values were better than the control group, and the difference was significant (P<0.05).② observation group in the AKP, FFA values after treatment than the control group, and the difference was significant (P<0.05).③ observation group rash during treatment, the incidence of diarrhea were (0.00%, 2.78%), were lower than the control group (11.11%, 16.67%), and the difference was significant (P<0.05).ConclusionYinzhihuang particle treatment of neonatal jaundice effect is good, worthy of further research and application.

Objective To investigate the clinical effect and safety of Smecta, Clostridium butyricum powder particles combined with Xingpiyang'er particles on pediatric digestive benign diarrhea. Methods All 112 cases of children with diarrhea indigestion as research subjects were randomly divided into study group and the control group, 56 cases in the control group were given smecta treatment, research group were given on the basis of the control group Clostridium and Xingpiyang’er particles. Results The study group stool frequency recovery time, body temperature returned to normal, stool recovery time was significantly better than the control group, the differences were statistically significant (P<0.05);the total effective rate of research group was 96.43%,significantly better than 73.21% in the control group, the differ-ences were statistically significant (P<0.05);after treatment, the HAMA score of research group was significantly lower than the control group, with statistical significance (P<0.05);adverse reactions rate of research group was 5.36%, with no obvious difference compared to the control group (P>0.05). Conclusion Children with indigestion diarrhea in chil-dren using smecta, Clostridium butyricum powder particle therapy combined Xingpiyang'er particles particks, can ef-fectively and quickly improve the symptoms of children with diarrhea, the effect is significant, it is worth promoting.