Objective: To explore the effects of sensory integration training on the behaviors and cognition in children with attention deficit hyperactivity sorder (ADHD) . Methods: Fifty-two children with ADHD (experimental group) were undergone sensory integration training for 60 times and their behaviors were evaluated with the Corners Parents Symptom Questionnaire (PSQ), and the cognition function was determined with the Combined Raven's Test (CRT) and Wisconsin Card Sorting Test (WCST) before and after the training. Another 52 healthy volunteers were recruited as controls and given the corresponding tests described above for comparison of the results. Results: The scores of conduct disorder, compulsion, hyperactivity and hyperactivity index in children with ADHD were decreased significantly than those of controls after training [(0.60 ± 0. 34) vs. (0.68 ± 0.35), (0.92±0.57) vs. (1.25±0.70), (0.82±0.29) vs. (1.08±0.44); P<0.05] .Inaddition, the improvement was found in IQ, categories control, and conceptive level as compared with that before the training [such as IQ, (105. 37 ±22.76) vs. (97. 37 ±24.15); P<0.001], whereas the scores of response error, response error percentage, first category and persistent errors were decreased after the training [such as response error, (39.40 ± 22.22) vs. (46.60 ±23.44), P<0.001] . For the experimental subjects, the scores in the first response number and the persistent errors percentage right after the training were higher compared with the controls [(12.03 ±5.08) vs. (10.65±0.84), (50.75 ±18.35) vs. (39.95 ± 15. 34); Ps<0.05] .Conclusion: The sensory integration training can improve the behaviors and cognition in children with ADHD, but it produces fewer effects on some of the executive functions despite clinical symptom relief to a certain extent.

Objective:To explore the relationship between stress perception and sleep quality among college students, as well as the chain mediating role of expression inhibition and anxiety emotions.Methods:From October to December 2022, a cross-sectional survey was conducted among 785 college students using the perceived stress scale (PSS-14), emotion regulation questionnaire (ERQ), self-rating anxiety scale (SAS), and Pittsburgh sleep quality index (PSQI). SPSS 26.0 software was used for common method bias testing, Pearson correlation analysis, and stratified regression analysis.PROCESS 3.5 macro program was used for mediating effect test.Results:(1) The correlation analysis results indicated that there were significant positive correlations between stress perception (39.22±7.63), expression inhibition (15.95±4.28), anxiety (45.85±11.70) and sleep quality (5.87±3.28)( r=0.120-0.596, all P<0.05). (2) The results of path analysis showed that stress perception could directly predict sleep quality, with a effect size of 0.243 (95% CI=0.172-0.313). Stress perception could indirectly affect sleep quality through anxiety emotion, with a effect size of 0.229 (95% CI=0.178-0.283). Stress perception could affect sleep quality through the chain mediation of expression inhibition and anxiety emotion, and the effect size was 0.010 (95% CI=0.002-0.019). Conclusion:Stress perception can directly predict sleep quality, and can also indirectly predict sleep quality through partial mediating effects of anxiety and chain mediating effects of expression inhibition and anxiety.

Objective To evaluate the effect of conversion from mycophenolic acid (MPA) to mizoribine (MZR) in renal transplant recipients with gastrointestinal tract (GI) symptoms.Methods A total of 355 renal transplant recipients with GI symptoms caused by MPA administration were enrolled from April 2015 to March 2017 in 25 different renal transplant centers in China.The symptomatic improvement of GI before (baseline) and after conversion to MZR (1,2,4 weeks) was assessed by each item of GI symptoms indication.In addition,the efficacy and safety of the conversion therapy during 12 months were determined.Results Patients showed improvement in GI symptoms including diarrhea,abdominal pain,abdominal distention and stomachache after conversion to MZR 1,2,4 weeks (P＜0.05).In patients with different severity of diarrhea,conversion to MZR therapy significantly improved diarrhea (P＜0.05).During 12 months,no patient experienced clinical immune rejection.We did not observe any infections,leucopenia and other serious side effects.Conclusion MZR could markedly improve GI symptoms caused by MPA administration in renal transplant recipients.

【Objective】 To explore the correlation between abnormal thalamic functional connectivity (FC) and memory loss in maintenance hemodialysis patients with end-stage renal disease (ESRD). 【Methods】 An auditory verbal learning test (AVLT-H) was conducted on 22 patients with ESRD and 28 age-, sex-, and education-matched healthy controls (HC) to evaluate memory function. After that, resting-state functional magnetic resonance imaging (rs-fMRI) data were gathered, and a whole-brain FC analysis centered on the thalamus was executed to discern variations in thalamic FC between the two groups. Finally, Pearson and Spearman correlation analyses were carried out. 【Results】 Compared to the HC group, the ESRD group exhibited notably lower scores in IR-S (P=0.002), SR-S (P<0.001), and LR-S (P=0.005). Concurrently, the ESRD group demonstrated diminished FC of the right thalamus with the left superior frontal gyrus, the left parietal lobule, the right suproccipital gyrus, the right anterior cuneus, and the right middle frontal gyrus (P<0.05, TFCE correction). Additionally, reduced FC were observed between the left thalamus and the left gyrus rectus, the left parietal lobule, and the right parietal lobule in the ESRD group (P<0.05, TFCE correction). Moreover, the FC values between the left thalamus and the left gyrus rectus in the ESRD group displayed significant negative correlations with IR-S (r=-0.499), SR-S (r=-0.458), and LR-S (r=-0.455) (all P<0.05). 【Conclusion】 Memory impairment is evident in ESRD patients undergoing maintenance hemodialysis, and it appears to be intricately linked to anomalous FC within the left thalamus and the left gyrus rectus. These findings offer potential imaging markers for monitoring memory dysfunction in individuals with ESRD.

【Objective】 To investigate dynamic regional homogeneity (dReHo) abnormality in end-stage renal disease (ESRD) patients by using resting-state functional magnetic resonance imaging (rs-fMRI). 【Methods】 A total of 26 ESRD patients and 26 healthy controls (HC) matched in gender, education level and age were included. Rs-fMRI scanning was performed in all subjects. All the subjects were tested by using auditory verbal learning test Huashan version (AVLT-H) and Montreal Cognitive Assessment (MoCA) to assess cognitive function before collection of MRI data. T-test was used to observe the difference in dReHo at global level between the two groups. Pearson and Spearman correlation analyses were made to estimate the correlation between abnormal brain regions and clinical scales. 【Results】 Compared with HC group, the dReHo value in ESRD patients reduced on the bilateral superior margin gyrus, left insula, left posterior central gyrus, and left putamen (P<0.05, replacement test correction). The dReHo values of left superior margin gyrus (r=-0.534, P=0.005) and left insula in ESRD patients (r=-0.422, P=0.032) were negatively correlated with the LR-S score, and the dReHo value of the left margin was negatively correlated with the SR-S score (r=-0.468, P=0.016). 【Conclusion】 There are abnormal dReHo values in several brain regions in ESRD patients during resting state, which is related to the patients’ cognitive function. The variation of dReHo value provides a new objective imaging basis for evaluating the cognitive function of ESRD patients.