1.Mouse-adapted SARS-CoV-2 replicates efficiently in the upper and lower respiratory tract of BALB/c and C57BL/6J mice.
Jinliang WANG ; Lei SHUAI ; Chong WANG ; Renqiang LIU ; Xijun HE ; Xianfeng ZHANG ; Ziruo SUN ; Dan SHAN ; Jinying GE ; Xijun WANG ; Ronghong HUA ; Gongxun ZHONG ; Zhiyuan WEN ; Zhigao BU
Protein & Cell 2020;11(10):776-782
Adaptation, Physiological
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Adenosine Monophosphate
;
administration & dosage
;
analogs & derivatives
;
pharmacology
;
therapeutic use
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Administration, Intranasal
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Alanine
;
administration & dosage
;
analogs & derivatives
;
pharmacology
;
therapeutic use
;
Animals
;
Betacoronavirus
;
genetics
;
physiology
;
Chlorocebus aethiops
;
Coronavirus Infections
;
drug therapy
;
virology
;
Disease Models, Animal
;
Female
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Host Specificity
;
genetics
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Lung
;
pathology
;
virology
;
Male
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Mutation, Missense
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Nasal Mucosa
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virology
;
Pandemics
;
Pneumonia, Viral
;
drug therapy
;
virology
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RNA, Viral
;
administration & dosage
;
genetics
;
Turbinates
;
virology
;
Vero Cells
;
Viral Load
;
Virus Replication