Objective To analyze the effect of perioperative nursing intervention on self management and symptom control in patients with knee joint degenerative joint disease (KOA), and to summarize the experience of nursing improvement.Methods A total of 84 cases were divided into control group and observation group using the random number, given routine nursing and comprehensive nursing intervention, respectively.Special attention should be paid to prevention and control of pain and swelling, improvement of the rehabilitation training and life management.Results Before discharge, HSS score at third month and sixth month in the observation group was higher than that in the control group, the observation group had higher excellent rate was than that of the control group at sixth months, the difference was statistically significant(100% vs.85.71%, P<0.05);Observation group had less swelling time, the mean VAS on the third postoperative day, and the ipsilateral knee start time than the control group.After 1 week, knee training times, training maintenance time of knee joint after discharge were higher than the control group, the difference was statistically significant (P<0.05).Conclusion Strengthening the comprehensive nursing intervention can improve the level of disease management and the control effect of the symptoms, which is helpful to the recovery of knee joint function.

Objective To analyze the effect of perioperative nursing intervention on self management and symptom control in patients with knee joint degenerative joint disease (KOA), and to summarize the experience of nursing improvement.Methods A total of 84 cases were divided into control group and observation group using the random number, given routine nursing and comprehensive nursing intervention, respectively.Special attention should be paid to prevention and control of pain and swelling, improvement of the rehabilitation training and life management.Results Before discharge, HSS score at third month and sixth month in the observation group was higher than that in the control group, the observation group had higher excellent rate was than that of the control group at sixth months, the difference was statistically significant(100% vs.85.71%, P<0.05);Observation group had less swelling time, the mean VAS on the third postoperative day, and the ipsilateral knee start time than the control group.After 1 week, knee training times, training maintenance time of knee joint after discharge were higher than the control group, the difference was statistically significant (P<0.05).Conclusion Strengthening the comprehensive nursing intervention can improve the level of disease management and the control effect of the symptoms, which is helpful to the recovery of knee joint function.

Objective To investigate the influence of Ginkgo biloba L. extract (EGB) on the expression of apoptosis-related protein and NF-κB signaling pathway in the spleen tissue of mice with radiation damage. Methods The mice were divided randomly into normal control group (NC), irradiation control group (IC), low dose EGB group (IC+EGBL), medium dose EGB group (IC+EGBM) and high dose EGB group (IC+EGBH) according to the random number table, with 12 rats in each group. The mice in the low, middle and high dose EGB groups were given EGB respectively by 5, 10, 20 mg/kg, and the normal and irradiation control group were given saline by intraperitoneal injection once daily for 14 days. On the 15th day, the mice in all groups were uniformly irradiated with 4.0 Gy γ-rays for one time except normal control group. After 24 hours, Bcl-2, Bax and caspase-3 protein expression were measured by immunohistochemical method. The IKKβ expression was detected by qRT-PCR method, and the content of NF-κB p65 and IKKα in serum was detected by Elisa method in spleen tissue. Results Comparing with IC group, the expression of Bax (54.31 ± 1.59, 42.04 ± 1.56, 32.08 ± 2.43 vs. 68.68 ± 3.12) and caspase-3 protein (55.73 ± 2.61, 45.81 ± 2.59, 36.78 ± 2.23 vs. 72.18 ± 1.84) in IC+EGBL, IC+EGBM and IC+EGBH group were significantly decreased (P<0.05), the expression of Bcl-2 protein (30.33 ± 1.28, 39.80 ± 2.86, 44.42 ± 3.64 vs. 22.80 ± 2.01) in IC+EGBL, IC+EGBM and IC+EGBH group significantly increased (P<0.05), the expression of IKKβ mRNA (1.43 ± 0.06, 1.31 ± 0.06, 1.17 ± 0.09 vs. 1.64 ± 0.10) and the level of NF-κB p65 (129.38 ± 8.41 pg/ml, 111.28 ± 9.09 pg/ml, 95.41 ± 6.88 pg/ml vs. 145.64 ± 6.29 pg/ml) and IKKα (160.10 ± 8.94 pg/ml, 144.00 ± 8.36 pg/ml, 108.84 ± 13.74 pg/ml vs. 176.38 ± 8.54 pg/ml) in IC+EGBL, IC+EGBM and IC+EGBH group significantly decreased (P<0.05). Conclusions The EGB can reduce the expression of apoptotic protein Bax and caspase-3 in spleen cells induced by radiation, elevate the expression level of apoptotic protein Bcl-2, and inhibit the damage caused by radiation by regulating NF-κB signaling pathway.

Objective To investigate the clinical value of health empowerment theory applied to postoperative rehabilitation management of elderly patients with femoral fracture. Methods A total of 94 cases of elderly patients with femoral fractures hospitalized in the Second Hospital of Jilin University from March 2015 to February 2017 were selected as the research objects. Using random number table method,the patients were randomly divided into the observation group and the control group, with 47 cases in each group. Patients in the control group received routine nursing, and patients in the observation group received nursing with health empowerment theory. Perceived empowerment level, the total incidence of postoperative complications, grade A healing rate of incisions and the situation of hip joint function of patients were evaluated and compared between the two groups. Results There were interaction among different times and groups of the perceived empowerment between two groups, and the differences were statistically significant (P< 0.01). There was no significant difference in the total incidence of postoperative complications between the two groups (P> 0.05). The grade A healing rate of patients in the observation group was significantly higher than that in the control group (P<0.05). The Harris score of patients that six months after surgery in two groups all elevated, and there was significant difference compared with the score before surgery (P<0.05), and the Harris score of patients in the observation group was higher than that of the control group (P<0.05). The good rate of hip joint function of patients in observation group that 6 months after surgery was significantly higher than that of control group (P< 0.05). Conclusions The application of health empowerment theory in elderly patients with femoral fractures is favorable for postoperative rehabilitation, and it can reduce the patients' postoperative pain and improve their hip joint function.

BACKGROUND: In the process of bone defect healing, the use of biological materials loaded with drugs for local defect intervention can accelerate the repair of the defect, which provides a new method for the local treatment of bone defects. OBJECTIVE: To introduce the local application of bone tissue engineering scaffolds loaded with bisphosphonates in bone defect repair and to summarize the effects of bone tissue engineering scaffolds as a drug delivery system on the bone defect healing. METHODS: The authors retrieved PubMed, Web of Science, Springerlink, Medline, WanFang and CNKI databases with "bisphosphonates, alendronate, zoledronate, bone defect, bone tissue engineering" as key words for relevant articles published from 2006 to 2018. Initially, 235 articles were retrieved, and finally 70 articles were selected for further analysis. RESULTS AND CONCLUSION: Bisphosphonate drug is an effective inhibitor of osteoclast dissolution. It can form a drug sustained release system on the local defect by being loaded to composite scaffolds, promote the formation of new bone and accelerate the healing of the defect. For the drug delivery system of bisphosphonates, suitable scaffold materials are crucial to the osteogenic effect of composite scaffolds in the defect area. At present, the carrier materials used for bisphosphonate-loaded composite scaffolds are mainly divided into organic materials and inorganic materials. Most polymeric organic materials can directly load bisphosphonates to form good drug sustained release in the local area and obviously exert their pro-osteogenic effects, while natural materials and most inorganic materials are often combined with other materials to form composite materials as carriers to optimize the carrier performance. Most studies have also confirmed that these composite materials loaded with bisphosphonates in the defect area exert osteogenic effect in the defect area.