1.Peptide-drug conjugates for tumor targeted diagnosis and treatment
Ying CHEN ; Rong-rong ZHENG ; Shi-ying LI
Acta Pharmaceutica Sinica 2023;57(8):2341-2352
Cancer is still one of the major diseases threatening human life and health. At present, how to achieve precise diagnosis and treatment of tumors is the biggest challenge in cancer treatment. Prodrugs use the tumor specificity of targeting molecules to deliver anticancer drugs to tumor sites, which can effectively improve drug bioavailability, therapeutic efficacy and safety, and are currently a hot spot in the research and development of anticancer drugs. The targeting molecules of prodrugs mainly include nucleic acid aptamers, polymers, antibodies, polypeptides, etc. Among them, polypeptides have the advantages of good biocompatibility, controllable degradation performance, high
2.Effect of Dendritic Cell Vaccine Coupled with Immune Adjuvant on the Inhibition of Murine Breast Carcinoma
Xin JIA ; Rong LI ; Ying-xin XU ; Li LI
Chinese Journal of Rehabilitation Theory and Practice 2006;12(5):381-382
ObjectiveTo investigate whether immune adjuvant can enhance the immunity of dendritic cell vaccine against murine breast cancer. Methods4 groups of mice with tumor are injected saline, immume adjuvant, dendritic cell (DC) vaccine and DC vaccine coupled with immune vaccine, respectively. Tumor volume and weight are measured 21 d later.ResultsThe tumor size in the DC vaccine coupled with immune vaccine group was significantly small compared with control group (P=0.001) and the DC vaccine group (P=0.047).ConclusionImmune adjuvant can enhance the immunity of dendritic cell vaccine against murine breast cancer.
6.Effects of Medium-and Long-chain Fatty Acid Triacylglycerol on Lipid Metabolism in Different Age's Male Subjects with Hypertriglyceridemia
Li-Ying WANG ; Qing XU ; Rong-Xin ZHANG
Chinese Journal of Prevention and Control of Chronic Diseases 2006;0(06):-
Objective To investigate the effects of medium-and long-chain fatty acid triacylglycerols on lipid metabolism in different age's male subjects with hypertriglyceridemia.Methods A randomized double-blind and controlled clinical trial was carried out among 74 male cases with hypertriacylglycerolemia.They were divided into two groups,one group was randomized to taking long-chain fatty acid triacylglycerol oil(LCT),and the other one to medium-and long-chain fatty acid triacylglycerol oil(MLCT).All cases in two groups asked to consume 20~30 g oil daily.Anthrepometric measurements and blood biochemical variables were measured at the initial and final time of the study.Results There were 34 and 33 cases left in LCT and MLCT group,respectively.A greater extent of decrease in the levels of blood TG,TC,apoB,apoA Ⅰ,apoAⅡ,apoC Ⅱ,apoC Ⅲ,apoE and LDL-C in male subjects aged less than 60 years was found in MLCT group than in LCT group after 8 weeks study(P
7.Analysis of misdiagnosis of xanthogranulomatous pyelonephritis
Xiang-Rong YING ; Zhang-Qun YE ; Xin-De LI ;
Chinese Journal of Urology 2001;0(06):-
Objective To improve the diagnosis and treatment of xanthogranulomatous pyelonephri- tis(XGP).Methods The clinical data of 18 cases(5 males and 13 females;mean age,47 years)with XGP were analyzed.Of them,6 had the lesion on the left,and 12 on the right.Before operation,XGP was mis- diagnosed as renal calculus with hydronephrosis in 4 cases,ureteral calculus with severe hydronephrosis in 3 cases,renal tuberculosis in 3 cases and renal carcinoma in 8 cases.Results Of the 18 cases,7 were diag- nosed to have XGP by frozen section during operation and 11 cases had a definite diagnosis by pathological examination after nephrectomy.After a follow-up of 6-124 months,no recurrence was observed in all these 18 cases.Conclusions Preoperative diagnosis of XGP is difficult.This disease is clinically characterized by foam cells in urine smear,low-density value of kidney CT and ineffective antibiotic therapy.Combined a- nalysis of clinical data and improvement of clinical recognition of XGP is the key to avoiding delayed diagno- sis or misdiagnosis of XGP.
8.Initial study on relationship between pICLn protein and hypotonic state.
Ying-zhe MA ; Gui-rong ZHANG ; Li-hua WANG
Chinese Journal of Applied Physiology 2005;21(1):24-25
Animals
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Cell Line
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Chloride Channels
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metabolism
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Epithelial Cells
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metabolism
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Escherichia coli
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metabolism
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Kidney
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cytology
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Osmotic Pressure
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Periplasm
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metabolism
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Swine
9.A case report of epiglottic angiomyolipoma. .
Li-hua ZHANG ; Rong-chao SUN ; Ying CHEN
Chinese Journal of Pathology 2005;34(10):645-645
Actins
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metabolism
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Angiomyolipoma
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metabolism
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pathology
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surgery
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Epiglottis
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Factor VIII
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metabolism
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Humans
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Laryngeal Neoplasms
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metabolism
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pathology
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surgery
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Male
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Middle Aged