1.Peptide-drug conjugates for tumor targeted diagnosis and treatment
Ying CHEN ; Rong-rong ZHENG ; Shi-ying LI
Acta Pharmaceutica Sinica 2023;58(8):2341-2352
Cancer is still one of the major diseases threatening human life and health. At present, how to achieve precise diagnosis and treatment of tumors is the biggest challenge in cancer treatment. Prodrugs use the tumor specificity of targeting molecules to deliver anticancer drugs to tumor sites, which can effectively improve drug bioavailability, therapeutic efficacy and safety, and are currently a hot spot in the research and development of anticancer drugs. The targeting molecules of prodrugs mainly include nucleic acid aptamers, polymers, antibodies, polypeptides, etc. Among them, polypeptides have the advantages of good biocompatibility, controllable degradation performance, high
2.Effect of Dendritic Cell Vaccine Coupled with Immune Adjuvant on the Inhibition of Murine Breast Carcinoma
Xin JIA ; Rong LI ; Ying-xin XU ; Li LI
Chinese Journal of Rehabilitation Theory and Practice 2006;12(5):381-382
ObjectiveTo investigate whether immune adjuvant can enhance the immunity of dendritic cell vaccine against murine breast cancer. Methods4 groups of mice with tumor are injected saline, immume adjuvant, dendritic cell (DC) vaccine and DC vaccine coupled with immune vaccine, respectively. Tumor volume and weight are measured 21 d later.ResultsThe tumor size in the DC vaccine coupled with immune vaccine group was significantly small compared with control group (P=0.001) and the DC vaccine group (P=0.047).ConclusionImmune adjuvant can enhance the immunity of dendritic cell vaccine against murine breast cancer.
5.Calcified and non-calcified ductal carcinoma in situ differences in sonographic and pathologic features
Rong YU ; Shengli LI ; Congying CHEN ; Ying YUAN ; Qiong ZHENG
Chinese Journal of Ultrasonography 2016;25(6):506-509
Objective To compare the sonographic and pathologic features of calcified and non-calcified ductal carcinoma in situ DCIS Methods A total of 83 lesions in 82 consecutive patients with pathologically confirmed pure DCIS were recruited One patient had bilateral lesions All lesions were divided into calcified DCIS and non-calcified DCIS according to the presence of calcifications on mammography Their sonographic features and pathologic reports for all patients with DCIS were retrospectively reviewed Statistical comparisons were performed using the chi-square test Results 1 Calcified DCIS showed positive ultrasound US findings in 80% 44 55 of cases The most common US finding was nonmass lesions 43 6% 24 55 Nine cases had pure ductal dilatations 16 4% 9 55 Non-calcified DCIS showed positive US findings in 96 4% 27 28 of cases The most common US finding was mass 89 2% 25 28 Two cases had pure ductal dilatations 7 1 % 2 28 No significant difference was found in the shape margin orientation posterior feature of a mass between the calcified and non-calcified groups P >0 05 Significant difference was observed in the size boundary echogenicity on ultrasound of the two groups P <0 05 2 At histopathology the pathological scores high nuclear grade positive ER status positive PR status positive Ki67 status and the presence of Her-2 neu oncogene were more common in the calcified group than in the non-calcified group Conclusions Calcified and non-calcified pure DCIS have different pathologic and sonographic features Calcified DCIS has more aggressive histological features than non-calcified DCIS.
6.Clinical Significance of Lymphocyte Subsets Change in Breast Cancer Patients before and after Treatment
Rong YUAN ; Jun LI ; Yiyu WANG ; Linqing YAN ; Ying LIU
Journal of Modern Laboratory Medicine 2014;(6):91-93
Objective To investigate the changes of lymphocyte subsets before and after the treatment with operation and chemotherapy in patients with breast cancer.Methods Using cytometer to measure lymphocyte subsets of CD3+,CD4+, CD8+,CD4+/CD8+ and NK of 25 breast cancer patients before and after treatment.The all 25 patients were treated with operation and chemotherapy after pathological diagnosis.The article compared the figures of T cell subsets before and after treatment.Results Compared with before operation and chemotherapy,the CD8+ statistically decreased after 1~3 months of treatment (t=2.57),and NK statistically increased after 3~6 (t=-2.23).After 6 months of treatment,the patients’ CD3+(t=-2.25),CD4+(t=-2.07)were statistically lower and NK (t=-3.56)was statistically higher.There was no significant difference for other items.Conclusion Lymphocyte subsets test against breast cancer patients can reflect immuni-ty level at a certain level during treatment.But how to explain the figures in different stage against treatment effectiveness and prognosis need further research.
7.A case of bilateral subclavian vein variation.
Jin-feng LIANG ; Li-rong WU ; Ying FANG
Chinese Journal of Cardiology 2010;38(3):277-278
Aged
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Female
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Humans
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Subclavian Vein
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abnormalities
9.Initial study on relationship between pICLn protein and hypotonic state.
Ying-zhe MA ; Gui-rong ZHANG ; Li-hua WANG
Chinese Journal of Applied Physiology 2005;21(1):24-25
Animals
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Cell Line
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Chloride Channels
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metabolism
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Epithelial Cells
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metabolism
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Escherichia coli
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metabolism
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Kidney
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cytology
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Osmotic Pressure
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Periplasm
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metabolism
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Swine