The fibrovascular membrane of proliferative diabetic retinopathy(PDR)cause severe damage to the structure and function of eye.The pathogenesis and development of fibrovascular membrane are associated with muhipie cellular factors,such as transforming growth factor(TGF),connective tissue growth factor(CTGF),basic fibroblast growth factor(bFGF),vascular endothelial growth factor(VEGF),platelet-derived growth factor(PDGF),tumor necrosis factor(TNF),extracellular matrix(ECM),matrix metalloproteinases(MMPs),endothelin and chemotactic factor,etc..So,the molecular mechanism of fibrovascular membrane of PDR is extremely complex.The relationship of pathogenesis on the fibrosis of PDR to cytokines,extracellular matrix,MMPs and other factors were summarized.

DNA, Neoplasm ; analysis ; Female ; Flow Cytometry ; Humans ; Hydatidiform Mole ; diagnosis ; genetics ; In Situ Hybridization, Fluorescence ; Microsatellite Repeats ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Pregnancy ; Triploidy ; Uterine Neoplasms ; diagnosis ; genetics

Choroidal neovascularization (CNV) ithe leading cause of vision disordecaused by variouretinal diseases.Apresent,many therapeutimethodare employed clinically,such aphotodynamitherapy (PDT),anti-vasculaendothelial growth facto(anti-VEGF) and transpupillary thermotherapy (TTT).However,none of them can cure CNV thoroughly and repeated treatmenirequired usually.The reason forecurrenCNV istill unclear.Choroidal hypoperfusion associated with Pdmay be one of the reasons.The purpose of thireview ito discusthe problem of choroidal hypoperfusion associated with PDfoCNV awell aitimpacon the eye and possible solutions.Thipapepresentevidenceof choroidal hypoperfusion aftePDand itrelationship with clinical outcomes.Meanwhile,the effecof combination therapy iassessed.Finally,low-fluence Pdirecommended apotential method to reduce choroidal hypoperfusion.

Aim To examine the protective effects of allopregnanolone against seizure on different animal models.Methods The protective effects of allopregnanolone against maximal electrical seizure (MES) and picrotoxin-induced seizure were studied in C57 mice 15 minutes after vehicle or drug intraperitoneal administration.Results In the MES test, we found that pretreatment with the phenobarbital or allopregnanolone produced a dose-dependent protective effect against seizure. The potency (ED50 value) of phenobarbital in the MES test was 2.40 mg?kg-1, with 95% confidence interval range from 1.22 to 4.72 mg?kg-1. The potency (ED50 value) of allopregnanolone in the MES test was 0.086 mg?kg-1, with 95% confidence interval range from 0.037 to 0.201 mg?kg-1, which was significantly higher than that of phenobarbital (P

Biomarkers, Tumor ; blood ; DNA, Neoplasm ; blood ; Humans ; MicroRNAs ; blood ; Molecular Diagnostic Techniques ; Neoplasms ; blood ; diagnosis ; Nucleic Acids ; blood

Humans ; Hydrogen Sulfide ; poisoning ; Male ; Methylene Blue ; therapeutic use ; Poisoning ; therapy ; Young Adult

Adult ; Aged ; Erythrocyte Indices ; Hemorheology ; Humans ; Male ; Middle Aged ; Silicosis ; blood

Adolescent ; Adult ; Aged ; Aged, 80 and over ; Autoantibodies ; biosynthesis ; Case-Control Studies ; Child ; Female ; Humans ; Immunoglobulin G ; biosynthesis ; Male ; Middle Aged ; Pancytopenia ; immunology ; pathology ; Receptors, Erythropoietin ; physiology ; Young Adult

Child ; Humans ; Karyotyping ; Male ; Osteochondrodysplasias ; classification ; diagnosis ; genetics