1.Influences of CO_2 pneumoperitoneum on circulation, P_(ET) CO_2 , and blood gas during laparoscopic hepatectomy
Medical Journal of Chinese People's Liberation Army 2001;0(12):-
Objective To investigate the effects of CO 2 pneumoperitoneum on circulation, P ET CO 2 and blood gas during laparoscopic hepatectomy. Methods Fourteen patients underwent laparoscopic hepatectomy with CO 2 pneumoperitoneum. The MAP, HR, CVP, P ET CO 2 , airway pressure and blood gas were monitored respectively before, 30min, 60min, 120min after pneumoperitoneum, and 10min and 30min after deflation of the abdomen. Results The HR, P ET CO 2 , PaCO 2 , and plood K + were significantly higher 30min after pneumoperitoneum compared with the values before pneumoperitoneum (P
2.Diagnostic significance of combined detection of rheumatoid factor and anticyclic citrullinated peptide antibodies in rheumatoid arthritis
Rong MU ; Xiaoyun SUN ; Zhanguo LI
Journal of Peking University(Health Sciences) 2003;0(05):-
Objective:To evaluate the significance of the combination of rheumatoid factor (RF) and anti-filaggrin antibodies (AFAs) in the diagnosis of rheumatoid arthritis (RA). Methods:Sera from 266 RA patients and 186 controls were studied. RF and some kinds of AFAs (including antikeratin antibodies, anti-perinuclear factor and anticyclic citrullinated peptide antibodies) were detected using immunofluorescence and ELISA respectively. The distributions of these antibodies were compared to determine the significance of the combination of RF and AFAs. Results:The sensitivity and secificity of RF for the diagnosis of RA were 65.8% and 81.8% respectively, as compared with those of anti-CCP or RF positive were 86.5% and 80.6% respectively. Only a slight change was found in the secificity and negative predictive value between them. RF could not be detected in 91 patients while 64.8% of them could be found to have at least one kind of AFAs. Conclusion:AFAs, particular anticyclic citrullinated peptide antibodies, could be helpful for the diagnosis of RA especially in RF-negative patients.
3.Relationship between Imaging Changes and Prognostic Assessment of Neonatal Brain Damage
tao, YU ; rong, LUO ; de-zhi, MU
Journal of Applied Clinical Pediatrics 2006;0(22):-
Neonatal brain damage including hypoxia-ischemia encephalopathy(HIE) and intracranial haemorrhage,may cause adverse neurodevelopmental outcome such as cerebral palsy.Earlier diagnosis is very important for the treatment of brain damage.This review is to elucidate the relationship between imaging changes(CT,MRI and ultrasonography) and prognostic assessment,thus provide reference for clinicians,the objective is focus on imaging changes of HIE and intracranial haemorrhages,which are 3 of the most frequently reported cases.
4.The significance of anti-p68 antibody in rheumatoid arthritis
Xiaoyun SUN ; Rong MU ; Zhanguo LI
Chinese Journal of Rheumatology 2003;0(09):-
Objective To evaluate the diagnostic specificity and sensitivity of anti-p68 antibody in rheumatoid arthritis (RA), and to analyze the relationship between anti-p68 antibody and the activity of RA . Methods Anti-p68 antibody was tested in the serum of 183 RA patients and 195 controls by indirect immunofluorescence (IIF). The clinical characteristics of RA between anti-p68 positive group and negative group were compared. Results ① The positive rate of anti-p68 antibody was 67.8% (124/183) in RA, 14.9% (17/114) in other rheumatic diseases and none in normal controls (0/81). Anti-p68 antibody was different from other auto-antibodies found in RA. ② Its sensitivity was 67.8% and specificity was 91.3% for RA, positive prediction rate was 87.9% and negative prediction rate was 75.1%. ③ There was statistic difference between the positive group and negative group in disease duration, RF and degree of X-ray changes. Conclusion ① Anti-p68 antibody is a new and specific serum maker for diagnosis of RA. ② The antibody is correlated with disease duration, RF and X-ray changes.
5.T cell response to cyclic citrullinated peptide in patients with rheumatoid arthritis
Rong MU ; Jing HE ; Zhanguo LI
Chinese Journal of Rheumatology 2001;0(05):-
Objective To examine the role of synthetic cyclic citrullinated peptide (CCP) in T cell autoreactivity in rheumatoid arthritis (RA) by detecting T cell proliferation. Methods Twenty-nine RA, 8 primary Sjo gren syndrome (pSS) and 16 osteoarthritis (OA) patients were included in this study. Proliferation of T cells was measured by methyltetiazolium incorporation following incubation with CCP. Results T cell response to CCP was more common in RA patients than in controls. The response rate to CCP was higher in late RA than in early RA. However, the response wasn′t associated with disease activity. A strong association between T cell proliferation and RF, anti-CCP antibody was observed. Conclusions T cell proliferation in response to CCP was found in the majority of RA patients, even in early RA, suggesting that the citrullinated peptide play an important role in the pathogenesis of RA.
6.Infectious arthritis caused by human parvovirus B19:case report and literature review
Yanying LIU ; Rong MU ; Zhan-Guo LI ;
Chinese Journal of Rheumatology 2003;0(08):-
Objective To understand the clinical profiles of arthritis after human parvovirus B19(B19) infection.Methods Four cases were described and the clinical and laboratory characteristics were analyzed. Results The median onset age of the 4 patients(2 females and 2 males)was 34 years old.Typical clinical manifestations included joint symptoms,flu-like malaise and erythematous rash.Anti-Bl9 IgM antibodies were all positive in 4 patients.B19 DNA was detected in blood samples of 3.Other types of arthritis were excluded. No relapses were noticed after followed-up of 1~3 years.Conclusion The Anti-B19 lgM and B19 DNA should be detected in patients suffer from arthritis with unknown origin.
7.Therapeutic effect of ~(99m)Tc-MDP and its role in proinflammatory cytokines in rheumatoid arthritis
Rong MU ; Shi CHEN ; Zhanguo LI ; Limin REN
Chinese Journal of Rheumatology 2001;0(01):-
Objective To evaluate the effect of 99m Tc-MDP on clinical and laboratory parameters in rheumatoid arthritis(RA).Methods The study was a prospective open cohort design.Clinical manifestations were recorded accordingly before and after 99m Tc-MDP intravenous infusion.Serum CRP,IL-1?,TNF-?and ESR were also measured.Results At the end point,morning stiffness,strength,index of joint tenderness,swelling,rest pain and physician assessment were all improved significantly(P
8.The clinical and laboratory characteristics of male patients with antiphospholipid syndrome
Chun LI ; Yuemeng XU ; Yan LI ; Rong MU ; Zhanguo LI
Chinese Journal of Rheumatology 2016;20(4):229-234
Objective To investigate the clinical and laboratory features of male patients with anti-phospholipid syndrome (APS).Methods Thirty-three male APS patients admitted to Peking University People's Hospital from January 2003 to April 2015 were enrolled.One hundred and fourteen female APS patients were selected as controls.Female patients with thrombosis were analyzed.x2 test, Fisher's exact test and t test were used for statistical analysis.Results Among male patients, 39.4% were primary APS and 60.6% were secondary APS.Compare with female patients,the prevalence of venous thrombosis was significantly higher than that in male APS (72.7% vs 29.8%,x2=19.719, P=0.000).The male APS patients experienced more episodes of thrombosis (75.8% vs 22.8%, x2=31.669, P=0.000) and not less than two locations of thrombosis than female (69.7% vs 22.8%, x2=25.321, P=0.000), there was still significant difference between male patients and female patients with thrombosis.There was no difference of antiphopholipid antibodies between the two groups.Conclusion Male patients with antiphospholipid syndrome are more prone to have thrombosis.More clinical interventions should be implemented in male patients with APS.
9.Clinical evaluation of oxaliplatin combined with S-1 or docetaxel for advanced gastric cancer
Shirong YANG ; Chengmao ZHAO ; Rong WANG ; Yuanzhong MU ; Gang ZHAO
Journal of International Oncology 2015;(6):426-429
Objective To evaluate the efficacy and safety of combination therapy of oxaliplatin and S-1 vs oxaliplatin and docetaxel for advanced gastric cancer (AGC)patients.Methods From April 201 1 to Janu-ary 201 3,62 cases of AGC were collected in the Fifth People′s Hospital of Qinghai Province.All cases were randomly divided into group A (31 cases)and B (31 cases)by random number table.In group A,oxaliplatin plus S-1 was administered,and in group B,oxaliplatin plus docetaxel was applied.The response rate (RR), time of diseases controlled rate (DCR),progression-free survival (PFS),overall survival (OS)and adverse reactions of the two groups were observed and compared.Results There were no statistically differences between group A and group B in RR (48.4% vs 54.8%),DCR (67.7% vs 77.4%),mPFS (5.4 months vs 6.2 months),mOS (9.0 months vs 9.8 months),and the statistical values were as follows:χ2 =0.26,P =0.71 1 ;χ2 =0.73,P =0.393;χ2 =0.51 ,P =0.473;χ2 =0.03,P =0.829.The incidence of degrees Ⅰ-Ⅱperipheral neuropathy (9.7% vs 22.6%),nausea and vomiting (1 2.9% vs 32.3%)in group A were signifi-cantly lower than those in group B (χ2 =5.78,P =0.002;χ2 =4.63,P =0.01 6).Conclusion Both the two chemotherapies are similar in therapeutic effect for patients with AGC.Oxaliplatin plus S-1 treatment may be better than oxaliplatin plus docetaxel in the tolerance of patients.
10.Screening, Identification and Bioinformatic Analysis of Taenia solium Cysticercus
Wen FANG ; Huaien BAO ; Liangliang XIAO ; Rong MU
Chinese Journal of Parasitology and Parasitic Diseases 1987;0(04):-
Objective To screen and identify specific antigens of Taenia solium cysticercus, and predict the function of target proteins using bioinformatics method. Methods Patients infected with Taenia solium were dewormed by decoction arecae and pumpkin seeds to collect worms, and eggs were then prepared. Six three-way crossed hybrid pigs were randomly divided into experimental group and control group, and each experimental pig was infected with 80 000 T. solium eggs. Serum samples were collected at 40 days after infection. The total protein of T. solium cysticercus was separated by two-dimensional electrophoresis, and Western blotting was performed to find out distinct antigens. Proteins from the two groups were identified by ESI-Trap MS. Query in NCBI database was made to confirm function of the proteins. Results 207?9 spots were detected through Coomassie brilliant blue-stained gels with Mr 14 400-94 000 and pI 3.0-10.0. Western blotting showed 7 specific antigen spots with pool sera of infected pigs. Four of the 7 antigens with known functions were respectively ascribed to cytoskeletal actin-2(adult-specific), tropomyosin(cysticercus-specific), AF239799-1 annexin (cysticercus-specific) and actin-1(cysticercus-specific). Conclutions Three specific antigens of Taenia solium cysticercus have been identified.