Adult ; Histiocytosis, Langerhans-Cell ; Humans ; Male

Object To determine the change of benzoic acid contents in decoctions prepared from various combinations of the recipe named SIWUTANG by RP HPLC to provide a reference for the control of the acid level Methods 8 decoctions of P lactiflora either alone or in combination with one or more of the other 3 components, according to permutation and combination, were prepared and their benzoic acid contents determined by RP HPLC Results The content of benzoic acid in the decoction of Radix Paeonie Alba alone was found to be 2 74 mg/g, while that of the other 7 combinations varied from 0 41～1 11 mg/g Conclusion The content of benzoic acid in SIWUTANG could be lowered significantly by the presence of Radix Angelica Sinensis, Radix Rehmanniae, and Rhizoma Chuanxiong

OBJECTIVE:To further perfect our Pharmaceutical Administration Law of PRC.METHODS:Contractive methods were used to analyze comparatively the legal liabilities in US FDCA and Pharmaceutical Administration Law of PRC with regard to awarding system for reporters,penalty terms and the disposition of the confiscated drugs.RESULTS&CON?CLUSION:Compared with the PRC Pharmaceutical Administration Law,the US FDCA is more comprehensive and more consummate.We should follow the legislative spirit in FDCA and take it as a reference to improve our Pharmaceutical Ad?ministration Law.

OBJECTIVE:To provide references for the establishment of drug recall system in China.METHODS: The drug recall system in U.S.A. was introduced so as to get some enlightenment for the drug safety in China.RESULTS & CONCLUSION: We could use the drug recall system in U.S.A. for references to improve our law criterion system and carry out drug recall system on a large scale.

Invasive fungal infections(IFI) is significantly increasing in the neonatal intensive care unit recent years.The characteristics of IFI are low diagnosis rate,high mortality and being prone to involve in the nervous system.In this paper,the epidemiology,pathogens,risk factors,diagnosis,treatment and prevention of neonatal IFI are reviewed to improve the understanding of this disease.

Humans ; Periodontal Diseases ; complications ; microbiology ; Periodontium ; microbiology ; Systemic Inflammatory Response Syndrome ; microbiology

ObjectiveTo explore the clinical effect of fiberoptic bronchoscope on mechanical ventilation patients with lung infection. Methods42 patients with serious lung infection acted mechanical ventilation were carried by fiberoptic bronchscope to check airstract,clear the waset,waste cultivating,and lung washing. ResultsThe waste cultivating was Positive. The conditions of 39 patients were improved effectively. The PaO2 ( t =-188. 539, P ＜0. 001 ), PaCO2 ( t =74. 481, P ＜ 0. 001 ), SaO2 ( t =-9. 025, P ＜ 0. 001 ) were statistically different after fiberoptic bronchoscope treatment. ConclusionFiberoptic bronchoscope could effectively identify the etiology and provide specif.ic antiinflamation treatment ;lung washing was beneficial for the airabstract waste extraction to improve the condition which was a relatively safe and effective method.

ObjectiveTo explore the mechanisms of proliferation and apoptosis of K562 cells induced by cytarabine. MethodsDifferent doses of cytarabine on the proliferotion at K562 cell 24h,48h,72h were detected by MTT. Cell cycle And Apoptosis rate were detected by FCM. ResultsEach concentration of cytarabine obvious inhibited the growth of K562 cells. In the same concentrations,function of proliferation inhibition with cytarabine increased by the extension of time,which showed dose and time effect relations. Cytarabine on K562 cell,G0/G1 phase cell proportion of role as cytarabine increased when extension of time, S period and the G2/M period cells were decreased.Apoptosis of K562 cell in proportion as drug concentration and effect time increases, which present Cytarabine timeconcentration dependence. CondusionCytarabine was apparent inhibition to proliferation of K562 cell leukemia cell, which could promote K562 cell apoptosis by time and concentration dependence way.

OBJECTIVE: To explore targeting of nanometer drugs and the adverse reaction during disease treatment. METHODS: The first author retrieved China National Knowledge Infrastructure with the key words of "nanometer drug, nanometer particle, drug carrier, targeting, adverse reaction" for articles published from 2001 to 2009 in Chinese. The articles addressing close content of targeting and adverse reactions of nanometer drugs were included, and Meta analysis, irrelevant or duplicated articles were excluded. Finally, 18 articles were included. We summarized the present studies concerning targeting and adverse reactions of nanometer drugs. RESULTS: Compared with common drugs, nanometer drugs had great surface area, strong chemical activity, and rapid rate of absorption. Nanometer drugs process a superiority compared with common drugs in aspects of traversing various barriers of the body, controlling release speed of drugs, and setting drug targeting. CONCLUSION: Compared with previous drugs, the targeting nanometer drugs present significant targeting, i.e. it can bring drugs to the targeting site. It not only can elevate curative effects, but decrease adverse reactions. Nanometer drugs as a new preparation provide a new thought for treating some refractory diseases, and bring a reformation for medical research. However, some nanometer materials show toxic properties, and especially the outcomes of interaction of nanometer materials to human or environment are still unclear. Therefore, the biological effects, action mechanism and elimination measures of toxicity of nanometer materials should be completely studied prior to the nanometer materials are made into commercialization products, which will bring a basic rationale for reasonable application of nanometer materials.

OBJECTIVE: To summarize research progress of tissue-engineered tendon stent material and its application for repairing tendon defect. METHODS: A computer-based online search was conducted with the key words of "tissue engineering, tendon, scaffold" in both Chinese and English from January 1993 to October 2009. Articles about dynamical performance of tissue-engineered tendon,experimental research and clinical application of tissue-engineered tendon were included, but duplicated studies and Meta analysis were excluded. Among 38 articles, 4 major viewpoints were discussed: research progress of tendon tissue engineering; biodynamical analysis of tissue-engineered tendon stent materials; application of biomaterials for tendon tissue engineering; clinical application of tissue engineering for repairing tendon defect. RESULTS: Natural polymer and synthetic macromolecule were major materials in tendon tissue engineering. The preparation and selection of stent materials depended on producing imitated materials with advanced performance and structure based on artificial synthetic materials, preparing natural derivative stent materials based on natural extracellular matrix, and constructing tissue-engineered tendon based on original bio-structure and bio-performance of biological tissue. Construction of tissue-engineered tendon must simulate three-dimensional physical environment in vivo. Microcomputer-controlled step motor was used to force tendon-matrix compound stent in order to increase proliferation velocity of tendon cells and secretory volume of collagen and develop into stress direction. CONCLUSION: Physical stimulation is simple, thus technique and instrument for constructing artificial tendon need to be further studied. Additionally, living implants which may completely replace body tissue and organ function still need to be further studied and solved.