Invasive fungal infections(IFI) is significantly increasing in the neonatal intensive care unit recent years.The characteristics of IFI are low diagnosis rate,high mortality and being prone to involve in the nervous system.In this paper,the epidemiology,pathogens,risk factors,diagnosis,treatment and prevention of neonatal IFI are reviewed to improve the understanding of this disease.

Adult ; Histiocytosis, Langerhans-Cell ; Humans ; Male

Object To determine the change of benzoic acid contents in decoctions prepared from various combinations of the recipe named SIWUTANG by RP HPLC to provide a reference for the control of the acid level Methods 8 decoctions of P lactiflora either alone or in combination with one or more of the other 3 components, according to permutation and combination, were prepared and their benzoic acid contents determined by RP HPLC Results The content of benzoic acid in the decoction of Radix Paeonie Alba alone was found to be 2 74 mg/g, while that of the other 7 combinations varied from 0 41～1 11 mg/g Conclusion The content of benzoic acid in SIWUTANG could be lowered significantly by the presence of Radix Angelica Sinensis, Radix Rehmanniae, and Rhizoma Chuanxiong

OBJECTIVE:To further perfect our Pharmaceutical Administration Law of PRC.METHODS:Contractive methods were used to analyze comparatively the legal liabilities in US FDCA and Pharmaceutical Administration Law of PRC with regard to awarding system for reporters,penalty terms and the disposition of the confiscated drugs.RESULTS&CON?CLUSION:Compared with the PRC Pharmaceutical Administration Law,the US FDCA is more comprehensive and more consummate.We should follow the legislative spirit in FDCA and take it as a reference to improve our Pharmaceutical Ad?ministration Law.

OBJECTIVE:To provide references for the establishment of drug recall system in China.METHODS: The drug recall system in U.S.A. was introduced so as to get some enlightenment for the drug safety in China.RESULTS & CONCLUSION: We could use the drug recall system in U.S.A. for references to improve our law criterion system and carry out drug recall system on a large scale.

Post-transcriptional regulation of prokaryotes is of pivotal importance to the quality control and stability main -tenance of multiple proteins .The ubiquitin and ubiquitin-like proteins-mediated modifications have widely participated in the manipulation of cell cycle control , subcellular localization and cellular metabolisms .Typical ubiquitin like proteins (UBLs) are ubiquitin,SUMO,Nedd8 and FAT10.Recently, the dynamic regulation mechanisms between sumoylation and de-sumoylation have become the cutting edge in the era of ubiquitin-like modifications.In this review, we briefly summa-rized the entire SUMO-mediated modification systems and the intricate balance regulation .We also discussed the counter acting star molecule SENP1 and its relationship with tumor initiation and progression ,immunological regulation and develop-mental homeostasis .

Objective:To investigate the cesarean perioperative usage in patients, and the rationality of drug evaluation.Methods: A retrospective analysis in February 2012 to August 2013 in our hospital for treatment of cesarean perioperative clinical information on the use of antimicrobial agents for statistics, and use frequency analysis method for analysis.Results: All patients with the highest rates of antibiotic Ornidazole, the highest consumption of Ornidazole, the highest amount of sales Ornidazole, cefotiam, the highest frequency of drug use Ornidazole use reasonable potassium penicillin drugs, cefotiam, ornidazole; most unreasonable use drugs penicillin, cefazolin amount of sorting/DDDs (medication on the number) were higher than a sort; cefmetazole the amount of sorting/ DDDs (medication on the number) Sort lowest value, and less than 1.Ratio of only 0.56% monotherapy, combination therapy of two drugs highest proportion is 76.67%. Conclusion: Perioperative cesarean section used antibiotics exists that use a longer time, the problem of improper dosage should strengthen supervision and improve the rational use of medicines in hospitals level.

Objective To promote students health knowledge and behavior and to create work that would provide the basis for evaluating the health promoting school. Method In 102 of the health promoting schools, using cluster random sampling method, in each applied school last digit survey date was used as a random number, selected classes were investigated about the infectious disease, chronic disease, vaccination, emergencies and other items. The subjects of the investigation were totally 5 368 people, 2 673 girls, and 2 695 boys, including primary school students 2 848 (rural students 1 272, 1 576 urban), middle school students 2 520 (rural students 1 127, 1 393 urban). All the 5 368 questionnaires were returned, 5 366 were valid. Chi-square test was used to evaluate health knowledge awareness and behavior formation rate, P<0.05 was regarded as having statistical significance. Result Overall, the awareness rate of knowledge (84.5%) and behavior formation rate (76.5%) of girls were higher than those of boys (83.4%, 75.1%) (χ2=26.17, 13.23, P<0.05). The awareness rate of knowledge of primary school girls (83.1%) and their behavior formation rate (76.9%) were also higher than those of primary school boys (81.9%, 74.5%) (χ2=13.70, 21.58, P<0.05) city primary school students; knowledge rate (85%) and behavior formation rate (77.6%) of urban students were higher than those of rural students (80.2%, 74.1%) (χ2=226.99, 49.28, P<0.05). The awareness rate of knowledge of middle school girls (86.1%) was higher than that of middle school boys (85.1%) (χ2=9.73, P<0.05);awareness rate of knowledge (85.8%) of middle school urban students was higher than that of rural students (84.3%) (χ2=22.37, P<0.05). The awareness rate of silver and bronze school knowledge (84.0%, 84.0%) was higher than that of gold (80.6%) (χ2=19.02, 20.08, P<0.05);the gold medal school behavior formation rate (83.3%) was higher than that of silver and bronze school (76.2%, 75.4%) (χ2=30.57, 38.76, P<0.05), silverbehavior formation rate (76.2%) was higher than the that of bronze medal schools (75.4%) (χ2=3.99, P<0.05). Conclusion The school health promotion work is still focusing on health knowledge education stage, the awareness rates of knowledge and behavior formation rates are not completely consistent. Health promotion has not become a liability and the concept of the schools surveyed.

The paper introduces concept, value, content, composition and frame theory of the overall informatization framework, an-alyzes the requirements of regional health informatization, summarizes the main modes of regional health informatization construction in China and elaborates the overall framework of regional health informatization and positioning of each composing factors, in order to provide references for regional health informatization construction in various regions.

After a description of subject service by revealing Nature/Science contents and pushing Information Bulletin of Nature/Science-special issue of medical and life sciences in Library of Nantong University, its utilization was inves-tigated with questionnaire, and some novel ideas were put forward for deepening subject service in libraries.