1.Delayed Anaphylaxis to Red Meat Associated With Specific IgE Antibodies to Galactose.
Liping WEN ; Junxiong ZHOU ; Jia YIN ; Jin lu SUN ; Yi SUN ; Kai WU ; Rohit KATIAL
Allergy, Asthma & Immunology Research 2015;7(1):92-94
A novel delayed anaphylactic reaction to red meat, associated with tick bites and IgE antibodies against galactose-alpha-1, 3-galactose (alpha-gal), was reported in 2009 in the US, Australia and Europe. In this case, serum specific IgE to galactose-alpha-1, 3-galactose (>100 kU/L) and IgE to multiple non-primate mammalian proteins were positive. However, the pathogenesis of this disease remains unclear. We report the first case in Asia of delayed anaphylactic reaction to red meat, which was induced by bites from the hard tick, Hematophagous ixodidae. We confirmed the increased concentration of IgE reactive epitopes in non-primate mammalian organs, which may be rich in alpha-gal proteins in lymphatic and endothelial tissues. All confirmed ticks associated with this disorder in the literature and in our case belonged to the hard tick family. We hypothesize that hard tick saliva is enriched with blood-type substances, such as oligosaccharides, from the non-primate mammal victim's blood after days to weeks of blood sucking, which sensitizes humans through the injection route while blood sucking.
Anaphylaxis*
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Antibodies*
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Asia
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Australia
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Epitopes
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Europe
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Food Hypersensitivity
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Galactose*
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Humans
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Immunoglobulin E*
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Ixodidae
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Mammals
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Meat*
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Oligosaccharides
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Saliva
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Tick Bites
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Ticks