Study on 112 patients who were admitted to ICU & PCC, Bachmai hospital from 1998 to 2001 due to rodenticide poisoning, we has shown that: rodenticide poisoning was a very common poisoning with high complication and mortality (8%); cardiac arrhythmia were usually the direct cause of death, especially in patients who ingested the white colored agent. The main clinical manifestations of rodenticide poisoning were neuromuscular symptoms (convulsion 49.1%, coma 32.14%, agitation 43.8%, hypereflexia 67.9% hypertonia 59.8%, mental disorders, rhabdomyolysis 33.9%); digestive symptoms (nausea, vomiting, abdominal pain 57.1%); respiratory failure (22.3%); cardiovascular compromise (hypertension 12.5%, disarrythmias 7.14%), acute renal failure (7.14%); hepatic dysfunction (elevated AST 72%, ALT 48%, bilirubin 34.48%); electrolyte disorders (hypocacemia 100%, hyponatremia 20.5%, hypokalemia 29.5%); hematological changes (leukocytosis 52.7%, elevated neutrophil 65.2%); metabolic disorders (hyperuricemia 26.1%, hyperglycemia 23.2%). The patient management should be an anticorrosion therapy, airway management, fluid infusion and early forced dieresis for the prevention of ARF, other critical care and monitoring.
Poisoning ; Rodenticides

Basal Ganglia ; pathology ; Female ; Humans ; Rodenticides ; poisoning ; Young Adult

Anticoagulants ; poisoning ; Humans ; Male ; Middle Aged ; Rodenticides ; poisoning

Superwarfarin intoxications that induce profound and prolonged coagulopathy are being increasingly reported, to such an extent that it is becoming a comparatively common intoxication. However, there have been few reported cases of superwarfarin intoxication with an inadvertent cause or an unknown origin. A 58-year-old man with recurrent painless hematuria was found to have an acquired deficiency of vitamin K dependent clotting factors, and a large amount of vitamin K was required to correct the coagulopathy. He had no history of warfarin use or any exposure to rodenticides, but brodifacoum was detected in his serum. It is important for physicians to be aware that significant coagulopathy can occur secondary to superwarfarin intoxication, without any known exposure to substances that might induce this.
4-Hydroxycoumarins ; Hematuria ; Humans ; Middle Aged ; Rodenticides ; Vitamin K ; Warfarin

A statistical study on 135 cases of acute poisoning who were treated in Pediatric department of Soon Chun Hyang College Hospital from May, 1974 to August, 1980 was performed. The results are as follows: 1. Seasonal incidence was more prevalent in summer. (from June to August, Table 2) 2. It occurred more frequently in male than female and high incidence was noted in 1 to 3 year-old age group(Table 5). 3. The causative chemicals were found to be 58 kinds & the commonest chemical was insecticides which were 16.3% of all cases. Rodenticides and tranquilizers(11.9%), D.D.S. (5.1%), kerosence(3.7%) were the next common causatvie agents. And drugs were more frequent than non-drug agents(Table. 3). 4. Accidental poisoning was more frequent than therapeutic and suididal purpose(Table 6). 5. It occurred most frequently during 3 to 6 O'lock in the afternoon and especially from 6 to 9 O'lock in morning and in the evening in the 0 to 1 year-old age. 6. There were complications which were aspiration pneumonia(3 cases). Corrosive pharyngitis (1 cases) and anoxic brain damage(1 cases) respectively. And death occurred in 1 cases due to insecticide.
Brain ; Child* ; Child, Preschool ; Female ; Humans ; Incidence ; Insecticides ; Male ; Pharyngitis ; Poisoning ; Rodenticides ; Seasons ; Statistics as Topic*

Acute Disease ; Adult ; Bridged-Ring Compounds ; poisoning ; Female ; Humans ; Male ; Middle Aged ; Rodenticides ; poisoning

Acute Disease ; Adult ; Autopsy ; Bridged-Ring Compounds ; poisoning ; Child ; Humans ; Male ; Poisoning ; pathology ; Rodenticides ; poisoning

Adolescent ; Adult ; Anticoagulants ; poisoning ; Coagulation Protein Disorders ; chemically induced ; diagnosis ; therapy ; Female ; Humans ; Male ; Rodenticides ; poisoning

Bridged-Ring Compounds ; poisoning ; Female ; Humans ; Middle Aged ; Occupational Exposure ; Rodenticides ; poisoning

4-Hydroxycoumarins ; poisoning ; Adolescent ; Adult ; Female ; Humans ; Male ; Rodenticides ; poisoning ; Young Adult