[Objective] To observe the effect of Wumei Wan on histological features of colic mucosa of rats with uleera-tive colitis. [ Methods ] Forty rats were randomly allocated to normal control group ( Group A), model group ( Group B), salicylazosulfapyridine group (Group C) and Wumei Wan group (Group D). Ulcerative colitis models were established by immune method combined with local stimulation. After gastric infusion treatment, the histological features of colic mucosa of rats were observed under light microscope and transmission electron microscope. [Results] The results of pathological slices showed histological feature of colic mucosa in Wumei Wan group was much improved as compared with Group C. [Conclusion] Wumei Wan has a certain effect in treating ulcerative colitis.