1.A Case of Disseminated Cutaneous Metastatic Carcinoma from Stomach Carcinoma.
Kang Seok LEE ; Hyun Sang LIM ; Seong Jun SEO ; Chang Kwun HONG ; Byung In RO
Annals of Dermatology 1998;10(2):108-111
We report a case of disseminated cutaneous metastatic carcinoma from stomach carcinoma in a 66-year-old male who complained chiefly of widespread cutaneous nodules. He had been admitted to the Department of Internal Medicine for stomach carcinoma. A radiological examination revealed a diffuse stomach wall thickening from the fundus to the antrum, and enlargement of paraaortic and pericaval lymph nodes during an abodominal CT scan. The clinical findings manifested above may suggest cutaneous metastasis from stomach carcinoma. A histological examination of the skin and stomach biopsies showed atypical cells with pleomorphic, hyperchromatic nuclei and bubble-like cytoplasm, which are consistent with poorly differentiated adenocarcinoma. Immunohistochemical stainings showed that these cells were positive for epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA) and low molecular weight cytokeratin.
Adenocarcinoma
;
Aged
;
Biopsy
;
Carcinoembryonic Antigen
;
Cytoplasm
;
Humans
;
Internal Medicine
;
Keratins
;
Lymph Nodes
;
Male
;
Molecular Weight
;
Mucin-1
;
Neoplasm Metastasis
;
Skin
;
Stomach*
;
Tomography, X-Ray Computed
2.The Changes of Autoantibodies against Hair Follicle in Alopecia Areata.
Hyun Sang LIM ; Seong Jun SEO ; Myeung Nam KIM ; Chang Kwun HONG ; Byung In RO
Korean Journal of Dermatology 1998;36(6):1018-1023
BACKGROUND: All though the cause of alopecia areata is not known, many studies have recenty focused on the autoimmunity of alopecia areata. OBJECTIVES: The objectives of this study were to detect autoantibodies against hair follicular antigens and compare the autoantibody level before and after treatment of alopecia areata. METHODS: We collected serum from: (a) 7 alopecia areata patients with good therapeutic responses, (b) 5 alopecia areata patients with poor therapeutic responses (c) 5 normal control people. First, we detected the antigens of hair follicles with SDS-PAGE. Secondly we reacted the antigens with the patients' and normal control serums by Western blotting. RESULTS: The follicular antigens were seen in the range of 44kD-57kD. Autoantibodies obviously apparent in patients of alopecia areata but not in the normal control. High concentrations of were Autoantibodies against follicular antigens seemed to be present in the patients with good therapeutic responses and as they had been treated well, the level of autoantiboies has decreased. Autoantibodies, however, were present in small amounts and were almost an changed between before and after treatment in the patients with poor therapeutic responses except for one case. CONCLUSION: There are kinds of autoantibodies against hair follicles in the serums of alopecia areata patients, and the titers of antibodies may be correlated with therapeutic responses.
Alopecia Areata*
;
Alopecia*
;
Antibodies
;
Autoantibodies*
;
Autoimmunity
;
Blotting, Western
;
Electrophoresis, Polyacrylamide Gel
;
Hair Follicle*
;
Hair*
;
Humans
3.Two Cases of Twenty-Nail Dystrophy.
Hyun Sang LIM ; Kang Seok LEE ; Seong Jun SEO ; Chang Kwun HONG ; Byung In RO
Annals of Dermatology 1999;11(2):86-89
Twenty-nail dystrophy is an idiopathic nail dystrophy in which all twenty nails are uniformly and simultaneously affected with excess longitudinal ridging and loss of lustre. The pathogenesis is controversial, and the treatment is unsuccessful. It is thought to have a self-limiting and reversible nature when it develops in childhood, but in adults, it is unusual and exists persistently. We re-port here two cases of adult patients with dystrophy of all twenty nails, whose ages were 58 and 55. The disease had been present for one year and may be associated with alopecia areata in the 58 year old and an idiopathic condition in the 55 year old. Negative results were obtained on mycological studies. Biopsies taken from the nail bed revealed marked hyperkeratosis consistent with nail dystrophy.
Adult
;
Alopecia
;
Alopecia Areata
;
Biopsy
;
Humans
4.Correlation between Androgenetic Alopecia and Lipid Parameters for Risk Factors of Coronary Artery Disease.
Seong Wook CHOE ; Yang Hyun YOON ; Byung In RO
Korean Journal of Dermatology 2004;42(10):1277-1284
BACKGROUND: The association of androgenetic alopecia and coronary artery disease has not been well documented although many studies have tried to reveal this association. This relationship is still a controversial issue. OBJECTIVES: The aim of this study is to investigate the association between the androgenetic alopecia and lipid parameters for risk factors of coronary artery disease. METHODS: The subjects of this study were 102 patients with androgenetic alopecia who had visited the Department of Dermatology, Pil-dong Hospital, College of medicine, Chung-Ang University during 2 years (from January 2000 to December 2001). The subjects of control group were 40 male individuals who had no androgenetic alopecia, no risk factor of coronary artery disease and no coronary artery disease. RESULTS: 1. There were significant differences in the serum total lipid, phospholipid, triglyceride between the patients and the control group. But there were no significant differences in serum LDL-cholesterol, HDL-cholesterol, and total cholesterol between the two groups. 2. There were significant differences in the serum total lipid, phospholipid, triglyceride between frontal baldness patients and the control group (p<0.05). But there were no significant differences in the serum LDL-cholesterol, HDL-cholesterol, and total cholesterol between the two groups. 3. There were significant differences in the serum total lipid, phospholipid, triglyceride, LDL-cholesterol, and total cholesterol between vertex baldness patients and the control group (p<0.05). But there were no significant differences in serum HDL-cholesterol between two groups. 4. There were no significant differences in the serum total lipid, phospholipid, triglyceride, LDL-cholesterol, HDL-cholesterol and total cholesterol between androgenetic alopecia patients who were increased serum testosterone and the control group. CONCLUSION: These data suggest that androgenetic alopecia involving the vertex scalp is associated with significantly increased total cholesterol and LDL-cholesterol for risk factors of coronary artery disease. We recommend that dermatologists should investigate the lipid parameters, especially total cholesterol and LDL-cholesterol in vertex baldness patients.
Alopecia*
;
Cholesterol
;
Coronary Artery Disease*
;
Coronary Vessels*
;
Dermatology
;
Humans
;
Male
;
Risk Factors*
;
Scalp
;
Testosterone
;
Triglycerides
5.A Case of Majocchi's Granuloma Caused by Trichophyton rubrum.
Seong Wook CHOE ; Yang Hyun YOON ; Seong Jun SEO ; Chang Kwun HONG ; Byung In RO
Korean Journal of Medical Mycology 2004;9(1):49-53
Dermatophytes usually do not invade beyond the epidermis. However mechanical breakage of the skin resulting from scratching or trauma and immunocompromised state may allow penetration of the fungi into reticular dermis. We report a patient with an unusual manifestation of Trichophyton rubrum infection. A 39-year-old male presented with 3.5x5 cm sized, erythematous, ulcerated lesion on the left heel for about 1 month. Histologic findings of the skin lesion showed granulomatous change and numerous hyphae in the dermis. Trichophyton rubrum was isolated on the fungus culture. The patient was treated with terbinafine (250 mg/day) for 10 weeks, resulting in the clearing of the skin lesion.
Adult
;
Arthrodermataceae
;
Dermis
;
Epidermis
;
Fungi
;
Granuloma*
;
Heel
;
Humans
;
Hyphae
;
Male
;
Skin
;
Trichophyton*
;
Ulcer
6.A Case of Majocchi's Granuloma Caused by Trichophyton rubrum.
Seong Wook CHOE ; Yang Hyun YOON ; Seong Jun SEO ; Chang Kwun HONG ; Byung In RO
Korean Journal of Medical Mycology 2004;9(1):49-53
Dermatophytes usually do not invade beyond the epidermis. However mechanical breakage of the skin resulting from scratching or trauma and immunocompromised state may allow penetration of the fungi into reticular dermis. We report a patient with an unusual manifestation of Trichophyton rubrum infection. A 39-year-old male presented with 3.5x5 cm sized, erythematous, ulcerated lesion on the left heel for about 1 month. Histologic findings of the skin lesion showed granulomatous change and numerous hyphae in the dermis. Trichophyton rubrum was isolated on the fungus culture. The patient was treated with terbinafine (250 mg/day) for 10 weeks, resulting in the clearing of the skin lesion.
Adult
;
Arthrodermataceae
;
Dermis
;
Epidermis
;
Fungi
;
Granuloma*
;
Heel
;
Humans
;
Hyphae
;
Male
;
Skin
;
Trichophyton*
;
Ulcer
7.Multiple brain abscesses treated by extraction of the maxillary molars with chronic apical lesion to remove the source of infection
Ki Hyun JUNG ; Seong Su RO ; Seong Won LEE ; Jae Yoon JEON ; Chang Joo PARK ; Kyung Gyun HWANG
Maxillofacial Plastic and Reconstructive Surgery 2019;41(1):25-
BACKGROUND:
Brain abscess is a life-threatening condition that occurs due to complications during a neurosurgical procedure, direct cranial trauma, or the presence of local or distal infection. Infection in the oral cavity can also be considered a source of brain abscess.CASE PRESENTATION: A 45-year-old male patient was transported with brain abscess in the subcortical white matter. Navigation-guided abscess aspiration and drainage was performed in the right mid-frontal lobe, but the symptoms continued to worsen after the procedure. A panoramic radiograph showed alveolar bone resorption around the maxillary molars. The compromised maxillary molars were extracted under local anesthesia, and antibiotics were applied based on findings from bacterial culture. A brain MRI confirmed that the three brain abscesses in the frontal lobe were reduced in size, and the patient's symptoms began to improve after the extractions.
CONCLUSION
This is a rare case report about multiple uncontrolled brain abscesses treated by removal of infection through the extraction of maxillary molars with odontogenic infection. Untreated odontogenic infection can also be considered a cause of brain abscess. Therefore, it is necessary to recognize the possibility that untreated odontogenic infection can lead to serious systemic inflammatory diseases such as brain abscess. Through a multidisciplinary approach to diagnosis and treatment, physicians should be encouraged to consider odontogenic infections as a potential cause of brain abscesses.
8.Three Cases of Generalized Lichen Nitidus.
Sung Wook RO ; Joo Hyun SHIM ; Tae Jong CHUN ; Hyun Sang LIM ; Seong Jun SEO ; Meyung Nam KIM ; Chang Kwun HONG
Annals of Dermatology 1999;11(4):280-282
Lichen nitidus(LN) is an uncommon chronic inflammatory disease of shiny, flat-topped, flesh-colored uniform papules most commonly located on the penis, forearms and wrists, lower abdomen, and thighs. LN almost has localized distribution, but in rare cases, it may become generalized. In Korea, three cases of generalized LN were reported. We report here three cases of generalized lichen nitidus in 31-year-old man, 8-year-old boy, and 6-year-old girl who had generalized numerous pinhead-sized, erythematous to flesh-colored, shiny papules. Microscopically, they had typical appearance of LN.
Abdomen
;
Adult
;
Child
;
Female
;
Forearm
;
Humans
;
Korea
;
Lichen Nitidus*
;
Lichens*
;
Male
;
Penis
;
Thigh
;
Wrist
9.Extensive Fasciitis in Sclerotic-type Chronic Cutaneous Graft-versus-Host Disease.
Seong Hun MOON ; Hyun Woo KIM ; Hyun Chul PARK ; Jeong Eun KIM ; Joo Yeon KO ; Young Suck RO
Korean Journal of Dermatology 2013;51(7):544-547
Fasciitis can occur very rarely with sclerotic-type chronic cutaneous graft-versus-host disease (GVHD). A 54-year-old woman presented with painful skin tightness on upper and lower limb with limited range of movement. She was diagnosed with chronic myelocytic leukemia 5 years ago and underwent allogeneic bone marrow transplantation. Histopathologically, the interlobular septum of subcutis and fascia were remarkably thickened with fibrosis and moderate inflammatory infiltrates accompanying the dilated lymphatic channels with considerable leakage of lymph fluids. Herein, we report a case of extensive fasciitis as a manifestation of chronic GVHD associated with poor prognosis.
Bone Marrow Transplantation
;
Fascia
;
Fasciitis
;
Female
;
Fibrosis
;
Graft vs Host Disease
;
Humans
;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
;
Lower Extremity
;
Prognosis
;
Skin
10.A Clinical Observation of Skin Tumors in the over 65 Year Old Age Group.
Seong Jun SEO ; Sung Hyun CHO ; Myeung Nam KIM ; Chang Kwun HONG ; Byung In RO
Korean Journal of Dermatology 2006;44(4):431-436
BACKGROUND: With the advance of socioeconomics and medical science, the population of elderly people has significantly increased. Therefore, it is necessary to study the fundamental epidemiologic survey of skin tumors in the elderly. OBJECTIVE: The purpose of this study was to evaluate the recent changes in malignant, benign and premalignant skin tumors, and then compare the results with other data previously reported. METHODS: 22,393 outpatients over 65 years old visited the Department of Dermatology, Chung Ang University Hospital, from January, 1999 to December, 2005. Among them, 260 patients who suffered with skin tumors were pathologically analyzed, confirmed, and classified as having eithes a malignant, premalignant, or benign tumor. RESULTS: The incidence of skin tumors in the over 65 year old age group was 8.0% (22,393) out of the total number of outpatients (249,486). There was no significant difference in the incidence of skin tumors from 1999 to 2001 (7.6~8.6%), but this increased gradually from 2002 to 2005 (9.1~9.8%). With the incidence of skin tumors according to age, 104 out of 260 patients (40%) were 65~70 years old, 96 patients (37.0%) were over 76 years old, and 60 patients (23.0%) were 71~75 years old. The incidence of women with malignant tumors was not much higher than in men, showing a ratio of 1.1:1. However, the incidence of men with benign tumors was a little higher than in women, with a ratio of 1.2:1. Generally, there was no significant difference in the ratio of incidence between men and women. The most common malignant tumor was basal cell carcinoma (41.1%), followed by squamous cell carcinoma (26.5%), malignant melanoma (14.7%), and metastatic carcinoma (7.4%). The most common premalignant lesion was actinic keratosis (50.0%), followed by Bowen's disease (31.6%) and Paget's disease (3.8%). Finally, the most common benign tumor was seborrheic keratosis (16.9%), followed by epidermal cysts (9.0%). The most common site for malignant tumors was the face (76.0%). The face was also the most common site for premalignant tumors (68.4%). However, benign tumors were found mostly on the trunk (50.4%) and the face (27.1%). CONCLUSION: We retrospectively studied 260 cases of skin tumors within elderly people. This study suggested that the incidence of malignant tumors and premalignant lesions had increased over the last few years.
Aged*
;
Bowen's Disease
;
Carcinoma, Basal Cell
;
Carcinoma, Squamous Cell
;
Dermatology
;
Epidermal Cyst
;
Female
;
Humans
;
Incidence
;
Keratosis, Actinic
;
Keratosis, Seborrheic
;
Male
;
Melanoma
;
Outpatients
;
Retrospective Studies
;
Skin*