PURPOSE: To evaluate the usefulness of CT angiography and to compare SSD(Shaded Surface Display) andMIP(Maximum Intensity Projection) in the diagnosis and preoperative evaluation of the cerebral aneurysms. MATERIALS AND METHODS: Twenty-six aneurysms in 20 patients were diagnosed on conventional angiography and surgerywas performed. For preoperative evaluation, all patients underwent CT angiography, with spiral CT for preoperativeevaluation. Using SSD and MIP techniques, the results were proccessed and compared; three radiologistsretrospectively analysed detectability, size, neck visualization, delineation of shape, direction, therelationship with surrounding vessels-including the feeding artery of the aneurysm-and intraluminal thrombicontaining calcification. RESULTS: Twenty five of 26 aneurysms (96.2%) were detected by CT angiography, while MIPand SSD depicted 25 (96.2%) and 24 (92.3%), respectively. The largest diameter of the aneurysms was 11-15mm infour cases, 6-10mm in ten, and 3-5mm in 12 (mean 7.38mm, SD=3.34). With regard to detectability, MIP led to onefalse negative result, and SSD to two false negative and one false-positive results. Aneurysm neck assessment byMIP was clear in 96.0% of cases (24/25), and by SSD in 83.3% (20/24). For the depiction of directions and feedingvessels of the aneurysms, and intraluminal thrombi containing calcification, MIP was superior to SSD, while fordepicting shape and the relationship with surrounding structures, SSD was superior to MIP. CONCLUSION: For theassessment of cerebral aneurysms, MIP is somewhat superior to SSD. The characteristics of aneurysms and theirrelationship with surrounding structures can, however, be better evaluated by combining the two techniques.
Aneurysm ; Angiography* ; Arteries ; Diagnosis* ; Humans ; Intracranial Aneurysm* ; Neck ; Silver Sulfadiazine* ; Tomography, Spiral Computed

PURPOSE: To demonstrate the MRI findings of olivopontocerebellar atrophy. MATERIALS AND METHODS: We retrospectively reviewed the MRI findings of eight patients who had been diagnosed by clinical manifestation and the peculiar pattern of atrophy and signal change on MRI. RESULTS: Seven patients had an atrophy of the olive, pons and cerebellum and increased signal change of the transverse pontine fiber, median raphe and middle cerebellar peduncle on T2WI. Of these, six patients had severe atrophy of the olive, pons and cerebellum and decreased signal change of the basal ganglia, red nucleus, substantia nigra or dentate nucleus on T2WI. Additionally, four of six patients had a cerebral atrophy. Except one patient who had an urinary incontinence, these 5 patients had not been associated with extrapyramidal or autonomic symptom. The other patient with relatively short duration of the disease had only cerebellar atrophy without signal change on T2WI . CONCLUSION: With progressing of the olivopontocerebellar atrophy, cerebral atrophy and decreased signal change of the basal ganglia, red nucleus, substantia nigra or dentate nucleus on T2WI is combined. Thus, MRI is essential in establishing the diagnosis and evaluating the severity of olivopontocerebellar atrophy.
Atrophy ; Basal Ganglia ; Brain* ; Cerebellar Nuclei ; Cerebellum ; Diagnosis ; Humans ; Magnetic Resonance Imaging* ; Olea ; Olivopontocerebellar Atrophies* ; Pons ; Red Nucleus ; Retrospective Studies ; Substantia Nigra ; Urinary Incontinence

OBJECTIVE: The aim of this study was to evaluate the changes of foot breadth and ball girth according to the height of shoes heel in the people without foot problems. METHOD: 480 subjects were evaluated with clinical examination, foot length, foot breadth and ball girth of right foot with and without shoes heel. The examination without shoes heel was performed without weight bearing. The examination with shoes heel was performed with weight bearing. 20 mm, 25 mm and 30 mm shoes heel were used for men, respectively. 30 mm, 40 mm and 60 mm shoes heel were used for women, respectively. RESULTS: There was significant increment in foot breadth and ball girth in the case with weight bearing, and significant increment in foot breadth and ball girth in the case of using higher shoes heel. But in women, foot breadth and ball girth using 60 mm shoes was shorter than that using 40 mm shoes. CONCLUSION: The breadth and the ball girth of the shoes according to the height of shoes heel should be considered to make more practical shoes.
Female ; Foot* ; Heel* ; Humans ; Male ; Shoes* ; Weight-Bearing

PURPOSE: Asymptomatic microscopic hematuria is a difficult problem faced at the offices of many urologists. This study was aimed at evaluating the ability for the detection of significant lesions, according to the grade of microscopic hematuria and the comparison of various diagnostic modalities. MATERIALS AND METHODS: Between March 1999 and December 2003, 755 adult patients that visited our hospital due to asymptomatic microscopic hematuria were examined according to the diagnostic algorithm. The male-to-female ratio was approximately 1:1.1 (366:389). Microscopic hematuria was divided into five grades. Lesions found at evaluation were categorized as either highly or moderately significant or insignificant lesions. RESULTS: 221 (29.3%) out of 755 patients were found to have lesions during evaluation. Of these 221 patients, 33 with highly significant lesions, including 4 urologic malignancies, 127 with moderately significant lesions and 61 with insignificant lesions, were detected. Correlation was shown between the degree of microscopic hematuria and the likelihood of detecting significant urologic diseases. The sensitivity and specificity for the detection of significant lesions by urine cytology, ultrasonography (USG), intravenous pyelography (IVP), cystoscopy, computed tomography (CT) and the combination of USG and IVP were 2.5/96.3%, 35.6/96.5%, 34.7/ 96.0%, 7.4/97.7%, 100/98.2% and 44.8/94.8%, respectively. CONCLUSIONS: The combination of USG and IVP for the detection of significant lesions at the initial examination was more beneficial than USG or IVP. Cystoscopy and CT are necessary additional diagnostic modalities for patients with abnormal findings at the initial examination and for those patients with asymptomatic microscopic hematuria who are at high risk.
Adult* ; Cystoscopy ; Hematuria* ; Humans ; Sensitivity and Specificity ; Ultrasonography ; Urography ; Urologic Diseases

Recent evidence shows that transcriptional silencing as a consequence of hypermethylation of CpG islands is an important mechanism in the inactivation of p16INK4 tumor suppressor gene. This study is designed to clarify the significance of p16INK4 hypermethylation in 23 cases of glioblastomas (GBMs) by methylation-specific polymerase chain reaction (PCR) and p16 immunostaining. Fourteen cases (60.9%) out of 23 GBMs revealed hypermethylation on p16. p16 immunostaining revealed that 13 (93%) of these 14 hypermethylation cases showed complete loss of immunoreactivity and only one (7%) case retained immunoreactivity. Among 9 methylation-negative cases, 4 were immunonegative, which might be related to mutations or deletions other than hypermethylation. The most significant finding was that of 17 cases with immunonegativity, 13 cases (76.5%) showed hypermethylation. We reconfirmed that p16 hypermethylation may be one of the major mechanisms of tumorigenesis of GBMs and the results between the methylation specific-PCR study and p16 immunostaining had a good correlation.
5' Untranslated Regions/metabolism* ; 5' Untranslated Regions/genetics ; Adult ; Antisense Elements (Genetics) ; Brain Neoplasms/pathology ; Brain Neoplasms/genetics* ; Brain Neoplasms/chemistry ; CpG Islands/physiology* ; DNA Methylation* ; Female ; Gene Silencing/physiology ; Glioblastoma/pathology ; Glioblastoma/genetics* ; Glioblastoma/chemistry ; Human ; Male ; Middle Age ; Polymerase Chain Reaction ; Protein p16/genetics* ; Protein p16/analysis

Medulloblastoma is one of the most undifferentiated primitive neuroectodermal tumors and represents about 30% of all posterior fossa tumors in children. Disseminated medulloblastoma, mainly involving cerebral surfaces, ventricles and the subarachnoid space can, in 50% of patients, be identified on intial imaging studies. One thirdof these lesions metastasize to an extracranial site, primarily to bone. Osseous metastases, which occur mainly after craniectomy are typically lytic, but osteoblastic lesions also may occur. We experienced the case of a 14year-old female patient with multiple bone metastases of medulloblastoma after craniectomy. Bone metastaticlesions were present in the right femur and thoracic spine and were osteoblastic or osteolytic
Child ; Female ; Femur ; Humans ; Infratentorial Neoplasms ; Medulloblastoma* ; Neoplasm Metastasis* ; Neuroectodermal Tumors, Primitive ; Osteoblasts ; Spine ; Subarachnoid Space

A primary malignant melanoma occurring within the male urethra is a very rare disease, which usually shows highly malignant potential. Due to the low incidence, the clinical features of this disease remain unclear, and the mode of treatment controversial. Herein, we report a case of a malignant melanoma of the male urethra in a 77 year old man, who was managed by transurethral resection, and has remained uneventful for a 6 month follow-up period.
Aged ; Follow-Up Studies ; Humans ; Incidence ; Male* ; Melanoma* ; Rare Diseases ; Urethra*

PURPOSE: Men with documented chronic prostatitis, with elevated serum prostate specific antigen (PSA), were investigated to assess whether treatment lowers serum PSA and thus avoids unnecessary biopsies. MATERIALS AND METHODS: The medical records of 46 men who presented with serum PSA higher than 4ng/ml, and subsequently diagnosed with chronic prostatitis, were retrospectively reviewed. After the administration of antibiotics and anti-inflammatory drugs for 4 to 8 weeks, the follow-up PSA levels were determined, and those with levels higher than 4ng/ml underwent a prostate biopsy. RESULTS: The mean PSA level decreased 61% from 11.66ng/ml before, to 3.79ng/ml after, treatment (p<0.001). In 30 patients the serum PSA level decreased to below 4ng/ml (mean 1.69), with these patients no longer having an indication for a prostate biopsy. In the remaining 16 patients the serum PSA level remained elevated above 4ng/ml, so they underwent a prostate biopsy. Pathological study revealed benign prostatic hyperplasia in 11 cases and prostate cancer in 5. The PSA level in patients associated with benign prostatic hyperplasia decreased 61.9% with treatment, from 19.96 to 7.88ng/ml (p=0.006) and the PSA in those associated with prostate cancer decreased 30.6% with treatment, from 12.85 to 7.32ng/ml (p<0.05). CONCLUSIONS: This study demonstrates that chronic prostatitis can cause elevation of serum PSA levels, and when identified, antibiotics and anti-inflammatory treatment can lower these levels and an unnecessary prostate biopsy can be avoided.
Anti-Bacterial Agents ; Biopsy ; Follow-Up Studies ; Humans ; Male ; Medical Records ; Prostate* ; Prostate-Specific Antigen* ; Prostatic Hyperplasia ; Prostatic Neoplasms ; Prostatitis* ; Retrospective Studies

PURPOSE: We evaluated the results of Holmium:YAG laser lithotripsy according to the size and location of the ureteral stones. MATERIALS AND METHODS: Between March 1998 and April 2007, the medical records of 203 patients who were treated with ureteroscopic Holmium: YAG laser lithotripsy due to ureteral calculi were reviewed. They were subgrouped by the size and the location of the ureteral stones. The results of treatment were evaluated by the stone free rate and the mean operation time of each group. RESULTS: The stone free rates of the upper, mid and lower ureter stone groups were 73.3%, 96.1% and 100%, respectively. There was a significant difference in the upper ureter stone group compared to the other two groups, and especially for the group with stone less than 10mm. Stone migration into the renal pelvis or calyx was a major cause of failure in the patients with upper ureter stones. 8 cases showed stone migration and 2 cases showed fragment migration. CONCLUSIONS: As Holmium:YAG laser lithotripsy has a low complication rate and a high stone free rate, it is an effective treatment modality for ureteral calculi. However, such procedures should be performed carefully because the thermal effect of the Holmium:YAG laser causes ureteral perforation, and especially in the cases of impacted or large stones. Other effective alternatives such as trapping devices need to be studied for patients with upper ureteral stones to prevent stone migration.
Holmium ; Humans ; Kidney Pelvis ; Lasers, Solid-State ; Lithotripsy ; Lithotripsy, Laser ; Medical Records ; Ureter ; Ureteral Calculi

PURPOSE: Video-assisted minilaparotomy surgery (VAMS) is a hybrid of conventional open and laparoscopic surgeries, which combines the benefits of both techniques. Our initial experiences with 33 cases were analyzed to assess the feasibility of VAMS. MATERIALS AND METHODS: Between May 2004 and April 2006, a total of 33 patients underwent VAMS-radical (n=20) and VAMS-live donor nephrectomies (n=13). The results of each operation were analyzed in terms of patient age, operation time, blood loss during surgery, time of oral intake and full ambulation, post operative stay period and amount of analgesic use. RESULTS: The mean age of the patients that had undergone the VAMS- radical and VAMS donor nephrectomies were 55.9 12.4 and 36.0 8.6 years, respectively. The mean results of the VAMS radical nephrectomy and VAMS donor nephrectomy with regard to the operative time, blood losses, time to oral intake, time to ambulation, postoperative length of stay and postoperative length of analgesics use were 225+/-72 / 253+/-67 minutes, 378+/-254 / 447+/-208cc, 2.1+/-0.7 / 1.4+/-0.5 days, 2.1+/-1.1 / 1.6+/-0.7 days, 6.2+/-1.1 / 6.2+/-1.0 days and 1.7+/-0.8 / 1.6+/-0.5 days, respectively. The mean warm ischemic time of VAMS donor nephrectomy was 2.4+/-0.8 minutes. The mean operation time of the 10 earliest cases of VAMS radical nephrectomy was 283 minutes; whereas, that of the last 10 cases decreased to 166 minutes. The mean operation time of the 7 earliest cases of VAMS donor nephrectomy was 299 minutes, which decreased to 206 minutes in the last 6 cases. Complications included 3 wound extensions in 5 patients experiencing massive intraoperative bleeding, 1 pneumonia, 1 wound dehiscence and 1 postoperative bleeding, all of which occurred in the 8 earliest cases. CONCLISIONS: VAMS could be a safe and feasible minimally invasive surgical procedure as experience is accumulated; when the initial learning curve has been overcome.
Analgesics ; Hemorrhage ; Humans ; Laparoscopy ; Laparotomy* ; Learning Curve ; Length of Stay ; Nephrectomy ; Operative Time ; Pneumonia ; Tissue Donors ; Walking ; Warm Ischemia ; Wounds and Injuries