Abstract Helminth infection has been a severe health issue mostly in the developing countries, where sanitation is not well maintained. The immune mechanism during helminth infection is well understood. The Th2 response is the primary weapon from the immune system to fight against helminth infection. The level of Th2 cells and cytokines are elevated during helminth infection. However, a prolonged Th2 response can cause liver fibrosis and reduce host survival. In the process of T cells differentiation, GATA-3 has a crucial role. It defines the population of Th1 and Th2. The expression of GATA-3 can be regulated through DNA methylation in the CGI sites of the gene. Hence, GATA-3 is able to co-express Th1 and Th2 in one cell, which would give less inflammation effect. This review aims to summarize research about the impact of DNA methylation of the GATA-3 genes to balance T cells population during helminth infection.