OBJECTIVE: To investigate the applicability of EuroQol 5-Dimension 3-Level questionnaire (Chinese Version 1.0) (EQ-5D-3L) in the assessment of life quality of patients with idopathic sudden hearing loss. METHOD: In this retrospect study, the EQ-5D-3L was assigned to 60 patients with idopathic sudden hearing loss before and after drug therapy. Audiometry examinations were undertaken and concomitant symptoms were recorded. A Wilcoxon rank sum test was applicated to the comparisons of results of EQ-5D-3L before and after the treatment, a t-test for results of EQ-VAS and a Kappa measurement for the consistency of certain dimension correlated with the symptoms. RESULT: Sixty patients completed the five questions and visual analog scale of the EQ-5D. A statistically significant changes of pain/discomfort, anxiety/depression before and after the treatment were observed (P < 0.05). The domains of mobility, self-care and usual activities did not show statistically significant different (P > 0.05). The dimension of pain/discomfort was in agreement with the concomitant symptoms. And the result of EQ-VAS was in agreement with the therapeutic outcome. CONCLUSION It is suitable for the EQ-5D to be a general health measure with sensitivity to clinical change in idiopathic sudden sensorineural hearing loss, which monitors the patients' outcomes.
Depression ; Hearing Loss, Sensorineural ; diagnosis ; Humans ; Quality of Life ; Self Care ; Surveys and Questionnaires ; Treatment Outcome ; Visual Analog Scale

OBJECTIVE: To construct and obtain ideal protein delivery vectors by researching the delivery efficiency and cytotoxicity to Hela cells using mPEG-PLGA-BSA-FITC-NPs. METHOD: The mPEG-PLGA nanoparticle was obtained through surface modification of PLGA with PEG, and deliver BSA-FITC into Hela cells in vitro. The positive cells were counted by Laser scanning confocal microscopy and the survival rate of Hela cells was calculated by MTT assay at different time points. RESULT: mPEG-PLGA-BSA-FITC-NPs shows the classic nanometer size, and the encapsulation efficiency reached 51. 2%. At the same time, the nanoparticles possess characteristics of slow release. By optimizing the delivery conditions, the highest efficiency of mPEG-PLGA-BSA-FITC-NPs was above 65.2%, and the cellular viability was about 85.7%. CONCLUSION mPEG-PLGA-BSA-FITC-NPs nanoparticles can successfully carry the target protein into cells as safe and effective as novel delivery materials of protein in vitro, and has shown slow release characteristics. The mPEG-PLGA-BSA-FITC-NPs provide ideal delivery vector for future application in clinical treatment of disease using nano-materials.
Drug Carriers ; Fluorescein-5-isothiocyanate ; analogs & derivatives ; HeLa Cells ; Humans ; Nanoparticles ; Particle Size ; Polyesters ; Polyethylene Glycols ; Serum Albumin, Bovine

OBJECTIVE: To observe the exposure of the vocal lesions under endoscopes of different angles and to contrast the endoscopes' influence on surgery. METHOD: Fifty patients with benign vocal lesions were selected randomly. During microlaryngoscopic surgery, the laryngoscope was placed softly and the different rigid endoscope (30 degrees, 45 degrees or 70 degrees) was connected to video system to expose the glottis and vocal folds. The operation was taken through looking at the color monitor. RESULT: The vocal fold lesions were completely examined and successfully excised in all patients, only two of them got soft palate mucosal abrasion. No one got complications. CONCLUSION Rigid endoscopy associated with microlaryngeal surgery brings a better observation to the vocal lesions and a lower incidence rate of complicatons. It's regarded that 45 degrees rigid endoscope is better than the others, for it provides not only a good exposure to the vocal cords, anterior commissure and subglottis, but also convenience to operate. The second one is 30 degrees rigid endoscope, which can save the cost, because of the widely using in many other departments.
Adult ; Aged ; Female ; Humans ; Laryngeal Diseases ; pathology ; Laryngoscopy ; methods ; Male ; Middle Aged ; Vocal Cords ; pathology ; Young Adult

OBJECTIVE: Summarize the treatment skills of esophagus perforation caused by esophageal foreign bodies. METHOD: Retrospectively analyze the seven cases of esophagus foreign body perforation with various complications in our department. RESULT: Six cases recovered in 3 to 18 days after operation, on average 14.2 day, while one case recovered in 49 days by conservative method. CONCLUSION Foreign bodies removing, fistulae repairing, abscess incising, effusion rinsing, effective antibiotics administrating and support treatment are effective to treat esophagus perforation caused by esophageal foreign bodies. It will take a relative long time to be treated only by conservative way.
Adult ; Aged ; Esophageal Perforation ; diagnosis ; etiology ; therapy ; Esophagus ; Female ; Foreign Bodies ; complications ; diagnosis ; therapy ; Humans ; Male ; Middle Aged ; Retrospective Studies

OBJECTIVE: To provide clinical reference by summarizing and analyzing characteristics, therapeutic principles and methods for special cases of esophageal foreign bodies. METHOD: Statistical analysis 182 cases with esophageal foreign bodies, including 41 special cases. Surgery 165 cases, 17 cases without surgery. RESULT: One hundred and seventy-five cases were cured, 7 cases improved. Hospitalization time 0.5-50 d (average 4.5 d). CONCLUSION It is important to learn about characteristics of esophageal foreign bodies, therapeutic principles and methods for special cases, and it's a key point to diagnosis early and remove the foreign bodies as soon as possible, and comprehensive treatment measures are really effective to process special cases.
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Esophagus ; Female ; Foreign Bodies ; therapy ; Humans ; Male ; Middle Aged ; Treatment Outcome ; Young Adult