1.Current national policies for infant universal bacille CalmetteGuérin vaccination were associated with lower mortality from coronavirus disease 2019
Risa EBINA-SHIBUYA ; Nobuyuki HORITA ; Ho NAMKOONG ; Takeshi KANEKO
Clinical and Experimental Vaccine Research 2020;9(2):179-182
An exciting debate has emerged whether bacille Calmette-Guérin (BCG) vaccination is effective for the coronavirus disease 2019 (COVID-19) pandemic. Some advocated that BCGvaccinated people are less suffered from the virus because BCG vaccination is recommendedin COVID-19 high burden countries. However, the others objected because this seemingly attractive relationship is explainable with confounding factors. In a multiple regression with 171 countries adjusting socioeconomical and climatic covariates, countries with current universal pediatric BCG policy were associated with 30-fold (95% confidence interval, 17–52) decrease of COVID-19 mortality per population compared to countries without the policy.
2.Current national policies for infant universal bacille CalmetteGuérin vaccination were associated with lower mortality from coronavirus disease 2019
Risa EBINA-SHIBUYA ; Nobuyuki HORITA ; Ho NAMKOONG ; Takeshi KANEKO
Clinical and Experimental Vaccine Research 2020;9(2):179-182
An exciting debate has emerged whether bacille Calmette-Guérin (BCG) vaccination is effective for the coronavirus disease 2019 (COVID-19) pandemic. Some advocated that BCGvaccinated people are less suffered from the virus because BCG vaccination is recommendedin COVID-19 high burden countries. However, the others objected because this seemingly attractive relationship is explainable with confounding factors. In a multiple regression with 171 countries adjusting socioeconomical and climatic covariates, countries with current universal pediatric BCG policy were associated with 30-fold (95% confidence interval, 17–52) decrease of COVID-19 mortality per population compared to countries without the policy.
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