Evaluation of several antihypertensive regimens involving reserpine, hydrochlorothiazide (Esidrex(R)) and clonidine (Catapres(R)) was conducted on 230 subjects with mild to severe hypertension. Chlordiaxepoxide (Librium(R)) which is a sedative was also administered to observe the effect in patients with mild labile hypertension. The results obtained were as follows; 1. All five regimens of chlordiazepoxide, reserpine, hydrochlorothiazide, hydrochlorothiazide plus reserpine and hydrochlorothiazide plus clonidine produced a significant decrease in average mean arterial pressure (systolic+diastolicc pressure/2) compared to control values (p<0.01). 2. Hydrochlorothiazide plus clonidine was the most effective pressure lowering regimen, resulting in an average fall of 39.3 mmHg in average mean arterial pressure and obtaining excellent result in 28.6% of the cases. 3. The order in the pressure lowering effect was hydrochlorothiazide plus clonidine, hydrochlorothiazide plus reserpine, hydrochlorothiazide, reserpine, and chlordiazide 4. There was no significant difference between hydrochlorothiazide plus clonidine and hydrochlorothiazide plus reserpine (p>0.1). 5. More reduction in diastolic pressure than systolic was observed with hydrochlorothiazide plus clonidine. 6. The results of hydrochlorothiazide alone, hydrochlorothiazide-reserpine and hydrochlorothaizide-clonidine were better than those of chlordiazepoxide and reserpine alone in patients with fundoscopic findings of Keith-Wagener Grade II. 7. There was difference in pressure lowering effect with hydrochlorothiazide plus clonidine between the group with and without albuminuria. 8. Hydrochlorothiazide plus clonidine were extremely effective in patients with severe hypertension, hydrochlorothiazide plus reserpine in patients with moderately severe hypertension, and reserpine and hydrochlorothiazide alone in patients with mild hypertension.
Albuminuria ; Antihypertensive Agents* ; Arterial Pressure ; Blood Pressure ; Chlordiazepoxide ; Clonidine ; Humans ; Hydrochlorothiazide ; Hypertension ; Reserpine

Two cases of multiple epiphyseal dysplasia in a 3 years old boy and a 10 years old girl are reported. Since Fairbanks description of the disease in 1935, it has been a well recognized entity which is a rare congenital developmental error characterized by mottling or irregularity in density and outline of several of the developing epiphyses, and dwarfism. Many reports indicate a definite hereditary and familiar distribution, particularly one series in which there were 10 cases in a single family, But in this report parent and siblings, all of whom were examined clinically, and roentgenographically showed no demonstrable stigmata of any growth disturbance. As the child develops, a subnormal growth rate becomes more obvious. The vertebrae are usually not affected so that dwarfing is confined to the extremity. The process rarely comes to attention of the physician until the child begin to walk, and then it is noted that one has a waddling gait and short stubby digits of the hands and feet. Intelligence is unaffected. Prognosis as to life expectancy and range of activity is good.
Child ; Christianity ; Dwarfism ; Epiphyses ; Extremities ; Female ; Foot ; Gait ; Hand ; Humans ; Intelligence ; Life Expectancy ; Male ; Osteochondrodysplasias ; Parents ; Prognosis ; Siblings ; Spine

No abstract available.
Heart* ; Thoracic Surgery*

Kaposi's sarcoma is a rare tumor comprising 0.1 per cent of all malignancies worldwide. There is, however, an increased ineidence following renal transplantation, immunosupression and in the acquried immunodeficency syndrome(AIDS) Kaposi's sarcoma has been shown to involve every organ of the body except the brain. Gastrointesinal involvement is the most common extracutaneous site of involvement. Gaatrointesinal Kaposis sarcoma is preaent in approximately half of patients with cutaneous Kaposis sarcoma and the acquired immune deficiency syndrome(AIDS). Although usually asymptomatic, gastrointestinal Kaposi's sarcoma may cause pain, bleeding, diarrhea, obstruction, intussusception, perforation. malabsorption, and protein-losing enteropathy. Three distinct gastroscopic appearances of Kaposi's sarcoma have been described: maculopapular, polypoid, and umbilicated nodular lesions. We report a case of Kaposis sarcoma of the stomach.
Brain ; Diarrhea ; Hemorrhage ; Humans ; Intussusception ; Kidney Transplantation ; Protein-Losing Enteropathies ; Sarcoma, Kaposi* ; Stomach*

The potential of malignant melanoma to metastasize to all parts of the body is well known. Metastatic melanoma of the stomach may present with vague gastrointestinal symptoms, abdominai pain, or gastrointestinal bleeding. When gastrointestinal symptoms occur in a patient with known melanoma, gastric metastases should be considered. Melanoma metastatic to the stomach develops multiple small ulcerating masses. These sharply delineated submucosal lesions have been described as having a "bull's eye" or "target" configuration. Barium X-ray study, endoscopy, cytology study, and biopsy may yield the diagnosis. The prognosis is poor. We report a case of metastatic melanoma of the stomach with the review of the literature.
Barium ; Biopsy ; Diagnosis ; Endoscopy ; Hemorrhage ; Humans ; Melanoma* ; Neoplasm Metastasis ; Prognosis ; Stomach* ; Ulcer

The results of alpha-acetyldigoxin(Dioxanin(R)) administration in 21 patients with congestive heart failure were as follows. Alpha-acetyldigoxin is a new oral preparation of cardiac glycoside derived from lanatosid C. 1. For rapid digitalization in 2-3 days, the initial dose was 1.2 to 2.6mg (average 1.96mg). For medium-fast digitalization in 4 days, the loading dose was 2.0 to 3.2mg (average 2.7mg). For slow digitalization 0.1 to 0.4mg was required for 5 to 6 days without loading dose. The maintenance dose was 0.1 to 0.4mg (average 0.33mg) daily. 2. The therapeutic effect of acetyldigoxin was excellent in 15 cases (71%), good in 4 cases (20%) and stationary in 2 cases (9%). 3. Side effects were observed in 2 cases with usual dosage regimen. One accidental case who took single dose of 4mg(20 tablests) developed supraventricular tachycardia with varying degree of atrioventricular block, ventricular bigeminy and premature beat but recovered completely after 6 days.
Acetyldigoxins* ; Atrioventricular Block ; Cardiac Complexes, Premature ; Estrogens, Conjugated (USP)* ; Heart Failure* ; Humans ; Tachycardia, Supraventricular

One case of cerebral embolism developed during cessation of supraventricular tachycardia in Wolff-Parkinson-White syndrome is reported with brief review. Twenty five years old, male was admitted to Seoul National University hospital with palpitation. He had numerous episodes of paroxysmal tachycardia for 3 years. He was diagnosed as Wolff-Parkinson-White syndrome at this hospital, ca 6 months prior to admission. Wolff-Parkinson-White syndrome was improved with atropine test at that time. The electrocardiogram on admission revealed Wolff-Parkinson-White synd rome associated with supraventricular tachycardia. He developed cerebral embolism after paroxysmal tachycardia of 22 days.
Atropine ; Electrocardiography ; Humans ; Intracranial Embolism* ; Male ; Seoul ; Tachycardia, Paroxysmal* ; Tachycardia, Supraventricular ; Wolff-Parkinson-White Syndrome*

Tibric acid is a new oral hypolipidemic agent with the chemical name of 2-chloro-5(3,5-dimethyl piperidinosulfonyl) benzoic acid. The results of tibric acid administration in 22 patients with primary hyperlipidemia were as follows. 1) Serum triglyceride level was significantly decreased in 84.6% of 22 cases with an average 43.9% decrease in serum triglyceride. 2) Serum cholesterol level was decreased in 59.1% of 22 cases with an average 15.8% decrease in serum cholesterol. The decrease in serum cholesterol level was not significant. 3) It seemed that there were significant falls in the serum triglyceride of the hyperlipoproteinemia type IV and IIb patietns and in the serum cholesterol of type IIa patients 4) The side effects of tibric acid were indigestion, loose stool and anorexia. There was no side effects in 63.6% of cases.
Anorexia ; Benzoic Acid ; Cholesterol ; Dyspepsia ; Humans ; Hyperlipidemias* ; Hyperlipoproteinemia Type IV ; Triglycerides

Upper G-I bleeding is a dangerous situation and effeetive control method without surgery is desirable. A hemostatic technique utilizing the dehydrating and fixative properties of pure ethanol was developed in Japan. This technique was performed through an endoscopic injector, in divided dose of 0,1 ~ 0.2 ml into several spots in the area surrounding the bleeding vessel in patients upper G-I bleeding excluding esophageal varies. We applieii this technique in treatment of 11 cases showing active bleeding of fresh blood clots. Rebleeding occurred in 2 cases(20%) and complete hemostasis was achieved in 9 cases(80%). We think this technique is safe and simple as an endoscopic hemostatic measure.
Ethanol* ; Hemorrhage* ; Hemostasis ; Hemostatic Techniques ; Humans ; Japan

A case of generalized primary amyloidosis with a reveiw of the literatures is reported. The 38 year old patient suffered from malabsorption syndrome for a year and was presented chronic renal failure with renal enlargment, myxedema and hemorrhagic gastritis. Biopsy of kidney and stomach revealed characteristic findings of amyloidosis by congo red stain and electronmicroscopy.
Adult ; Amyloidosis* ; Biopsy ; Congo Red ; Gastritis ; Humans ; Kidney ; Kidney Failure, Chronic ; Malabsorption Syndromes* ; Myxedema ; Stomach