1.Effects of Cigarette Smoking on Newborns and Infants in a Rural Community.
Rikako KOMATSU ; Akiko MIURA ; Eiko SATO ; Sachiko SASAKI ; Mariko ANBO ; Ryoko SATO ; Kazuo KOMATSU ; Toshihiro OKAMURA ; Kazuhiko TAKANO
Journal of the Japanese Association of Rural Medicine 1995;44(2):93-98
Many researchers report that cigarette smoking by parents adversely affects their children. We carried out a survey about cigarette puffing by distributing questionnaires to mothers of sucklings and little children. The survey found that mothers and family members were not well aware of the health consequences of passive smoking. It was also found that children frequently exposed to smoking are at high risk of contracting infections of the respiratory tract. The average weight at birth was less in babies borned by smoking mothers than by those who do not smoke. Furthermore, it was revealed that a larger number of smoking mothers had given birth to low birth weight infants than nonsmoking mothers had.
These findings suggested that passive cigarette smoking is linked to low birth weight and respiratory tract infection. We think it is incumbent on us, health-care professionals, to bring home to mothers and the rest of the family members how serious the consequences of passive smoking are.
2.A Randomized, Open-Label, Multicenter Trial of Topical Tacrolimus for the Treatment of Pruritis in Patients with Atopic Dermatitis.
Satoshi TAKEUCHI ; Hidehisa SAEKI ; Shoji TOKUNAGA ; Makoto SUGAYA ; Hanako OHMATSU ; Yuichiro TSUNEMI ; Hideshi TORII ; Koichiro NAKAMURA ; Tamihiro KAWAKAMI ; Yoshinao SOMA ; Eiichi GYOTOKU ; Michihiro HIDE ; Rikako SASAKI ; Yukihiro OHYA ; Makiko KIDO ; Masutaka FURUE
Annals of Dermatology 2012;24(2):144-150
BACKGROUND: Pruritis caused by atopic dermatitis (AD) is not always well controlled by topical corticosteroid therapy, but use of tacrolimus often helps to soothe such intractable pruritis in clinical settings. OBJECTIVE: To determine the anti-pruritic efficacy of topical tacrolimus in treating AD in induction and maintenance therapy. METHODS: Prior to the study, patients were randomly allocated into two groups, induction therapy followed by tacrolimus monotherapy maintenance, and induction therapy followed by emollient-only maintenance. In the induction therapy, the patients were allowed to use topical tacrolimus and emollients in addition to a low dose (<10 g/week) of topical steroids. Patients showing relief from pruritis were allowed to proceed to maintenance therapy. Recurrence of pruritis in maintenance therapy was examined as a major endpoint. RESULTS: Two-thirds of patients (44/68; 64.7%) showed relief from pruritis after induction therapy. Pruritis recurred in 23.8% (5/21) of the tacrolimus monotherapy group and in 100% (21/21) of the emollient group during maintenance period, a difference that was statistically significant. CONCLUSION: Use of topical tacrolimus is effective in controlling pruritis of AD compared to emollient.
Dermatitis, Atopic
;
Emollients
;
Humans
;
Pruritus
;
Recurrence
;
Steroids
;
Tacrolimus