1.Ischemic Complication of a Rare Traumatic True Brachial Artery Aneurysm: A Case Report
Ricardo GRANDE-GARCIA ; Javier E. ANAYA-AYALA ; Luis BARRAGÁN-GALINDO ; Renata VERA ; Hugo LAPARRA-ESCARENO ; Astrid VARELA-ARZATE ; Mónica CHAPA-IBARGÜENGOITIA ; Carlos A. HINOJOSA
Vascular Specialist International 2024;40(1):4-
True brachial artery aneurysms are rare. We present the case of a 47-year-old male who was referred to our clinic for the evaluation of progressive right arm claudication. He had suffered a gunshot wound in the right elbow 16 years before his symptoms. Computed tomography angiography revealed a thrombosed true brachial artery aneurysm. The patient was placed in the operating room, and aneurysm resection and reconstruction were performed using an interposition saphenous vein graft. His postoperative period was uneventful, and 1 year after the procedure, he remained asymptomatic. True brachial artery aneurysms associated with remote traumas are rare. This case illustrates the clinical presentation and successful management of arterial reconstruction using an autologous vein graft.
2.Mechanical Thrombectomy Versus Intravenous Thrombolysis in Distal Medium Vessel Acute Ischemic Stroke: A Multinational Multicenter Propensity Score-Matched Study
Hamza Adel SALIM ; Vivek YEDAVALLI ; Basel MUSMAR ; Nimer ADEEB ; Muhammed Amir ESSIBAYI ; Kareem El NAAMANI ; Nils HENNINGER ; Sri Hari SUNDARARAJAN ; Anna Luisa KÜHN ; Jane KHALIFE ; Sherief GHOZY ; Luca SCARCIA ; Benjamin Y.Q. TAN ; Benjamin PULLI ; Jeremy J. HEIT ; Robert W. REGENHARDT ; Nicole M. CANCELLIERE ; Joshua D. BERNSTOCK ; Aymeric ROUCHAUD ; Jens FIEHLER ; Sunil SHETH ; Ajit S. PURI ; Christian DYZMANN ; Marco COLASURDO ; Xavier BARREAU ; Leonardo RENIERI ; João Pedro FILIPE ; Pablo HARKER ; Razvan Alexandru RADU ; Thomas R. MAROTTA ; Julian SPEARS ; Takahiro OTA ; Ashkan MOWLA ; Pascal JABBOUR ; Arundhati BISWAS ; Frédéric CLARENÇON ; James E. SIEGLER ; Thanh N. NGUYEN ; Ricardo VARELA ; Amanda BAKER ; David ALTSCHUL ; Nestor R. GONZALEZ ; Markus A. MÖHLENBRUCH ; Vincent COSTALAT ; Benjamin GORY ; Christian Paul STRACKE ; Mohammad Ali AZIZ-SULTAN ; Constantin HECKER ; Hamza SHAIKH ; David S. LIEBESKIND ; Alessandro PEDICELLI ; Andrea M. ALEXANDRE ; Illario TANCREDI ; Tobias D. FAIZY ; Erwah KALSOUM ; Boris LUBICZ ; Aman B. PATEL ; Vitor Mendes PEREIRA ; Adrien GUENEGO ; Adam A. DMYTRIW ;
Journal of Stroke 2024;26(3):434-445
Background:
and Purpose The management of acute ischemic stroke (AIS) due to distal medium vessel occlusion (DMVO) remains uncertain, particularly in comparing the effectiveness of intravenous thrombolysis (IVT) plus mechanical thrombectomy (MT) versus IVT alone. This study aimed to evaluate the safety and efficacy in DMVO patients treated with either MT-IVT or IVT alone.
Methods:
This multinational study analyzed data from 37 centers across North America, Asia, and Europe. Patients with AIS due to DMVO were included, with data collected from September 2017 to July 2023. The primary outcome was functional independence, with secondary outcomes including mortality and safety measures such as types of intracerebral hemorrhage.
Results:
The study involved 1,057 patients before matching, and 640 patients post-matching. Functional outcomes at 90 days showed no significant difference between groups in achieving good functional recovery (modified Rankin Scale 0–1 and 0–2), with adjusted odds ratios (OR) of 1.21 (95% confidence interval [CI] 0.81 to 1.79; P=0.35) and 1.00 (95% CI 0.66 to 1.51; P>0.99), respectively. Mortality rates at 90 days were similar between the two groups (OR 0.75, 95% CI 0.44 to 1.29; P=0.30). The incidence of symptomatic intracerebral hemorrhage was comparable, but any type of intracranial hemorrhage was significantly higher in the MT-IVT group (OR 0.43, 95% CI 0.29 to 0.63; P<0.001).
Conclusion
The results of this study indicate that while MT-IVT and IVT alone show similar functional and mortality outcomes in DMVO patients, MT-IVT presents a higher risk of hemorrhagic complications, thus MT-IVT may not routinely offer additional benefits over IVT alone for all DMVO stroke patients. Further prospective randomized trials are needed to identify patient subgroups most likely to benefit from MT-IVT treatment in DMVO.
3.Mechanical Thrombectomy Versus Intravenous Thrombolysis in Distal Medium Vessel Acute Ischemic Stroke: A Multinational Multicenter Propensity Score-Matched Study
Hamza Adel SALIM ; Vivek YEDAVALLI ; Basel MUSMAR ; Nimer ADEEB ; Muhammed Amir ESSIBAYI ; Kareem El NAAMANI ; Nils HENNINGER ; Sri Hari SUNDARARAJAN ; Anna Luisa KÜHN ; Jane KHALIFE ; Sherief GHOZY ; Luca SCARCIA ; Benjamin Y.Q. TAN ; Benjamin PULLI ; Jeremy J. HEIT ; Robert W. REGENHARDT ; Nicole M. CANCELLIERE ; Joshua D. BERNSTOCK ; Aymeric ROUCHAUD ; Jens FIEHLER ; Sunil SHETH ; Ajit S. PURI ; Christian DYZMANN ; Marco COLASURDO ; Xavier BARREAU ; Leonardo RENIERI ; João Pedro FILIPE ; Pablo HARKER ; Razvan Alexandru RADU ; Thomas R. MAROTTA ; Julian SPEARS ; Takahiro OTA ; Ashkan MOWLA ; Pascal JABBOUR ; Arundhati BISWAS ; Frédéric CLARENÇON ; James E. SIEGLER ; Thanh N. NGUYEN ; Ricardo VARELA ; Amanda BAKER ; David ALTSCHUL ; Nestor R. GONZALEZ ; Markus A. MÖHLENBRUCH ; Vincent COSTALAT ; Benjamin GORY ; Christian Paul STRACKE ; Mohammad Ali AZIZ-SULTAN ; Constantin HECKER ; Hamza SHAIKH ; David S. LIEBESKIND ; Alessandro PEDICELLI ; Andrea M. ALEXANDRE ; Illario TANCREDI ; Tobias D. FAIZY ; Erwah KALSOUM ; Boris LUBICZ ; Aman B. PATEL ; Vitor Mendes PEREIRA ; Adrien GUENEGO ; Adam A. DMYTRIW ;
Journal of Stroke 2024;26(3):434-445
Background:
and Purpose The management of acute ischemic stroke (AIS) due to distal medium vessel occlusion (DMVO) remains uncertain, particularly in comparing the effectiveness of intravenous thrombolysis (IVT) plus mechanical thrombectomy (MT) versus IVT alone. This study aimed to evaluate the safety and efficacy in DMVO patients treated with either MT-IVT or IVT alone.
Methods:
This multinational study analyzed data from 37 centers across North America, Asia, and Europe. Patients with AIS due to DMVO were included, with data collected from September 2017 to July 2023. The primary outcome was functional independence, with secondary outcomes including mortality and safety measures such as types of intracerebral hemorrhage.
Results:
The study involved 1,057 patients before matching, and 640 patients post-matching. Functional outcomes at 90 days showed no significant difference between groups in achieving good functional recovery (modified Rankin Scale 0–1 and 0–2), with adjusted odds ratios (OR) of 1.21 (95% confidence interval [CI] 0.81 to 1.79; P=0.35) and 1.00 (95% CI 0.66 to 1.51; P>0.99), respectively. Mortality rates at 90 days were similar between the two groups (OR 0.75, 95% CI 0.44 to 1.29; P=0.30). The incidence of symptomatic intracerebral hemorrhage was comparable, but any type of intracranial hemorrhage was significantly higher in the MT-IVT group (OR 0.43, 95% CI 0.29 to 0.63; P<0.001).
Conclusion
The results of this study indicate that while MT-IVT and IVT alone show similar functional and mortality outcomes in DMVO patients, MT-IVT presents a higher risk of hemorrhagic complications, thus MT-IVT may not routinely offer additional benefits over IVT alone for all DMVO stroke patients. Further prospective randomized trials are needed to identify patient subgroups most likely to benefit from MT-IVT treatment in DMVO.
4.Mechanical Thrombectomy Versus Intravenous Thrombolysis in Distal Medium Vessel Acute Ischemic Stroke: A Multinational Multicenter Propensity Score-Matched Study
Hamza Adel SALIM ; Vivek YEDAVALLI ; Basel MUSMAR ; Nimer ADEEB ; Muhammed Amir ESSIBAYI ; Kareem El NAAMANI ; Nils HENNINGER ; Sri Hari SUNDARARAJAN ; Anna Luisa KÜHN ; Jane KHALIFE ; Sherief GHOZY ; Luca SCARCIA ; Benjamin Y.Q. TAN ; Benjamin PULLI ; Jeremy J. HEIT ; Robert W. REGENHARDT ; Nicole M. CANCELLIERE ; Joshua D. BERNSTOCK ; Aymeric ROUCHAUD ; Jens FIEHLER ; Sunil SHETH ; Ajit S. PURI ; Christian DYZMANN ; Marco COLASURDO ; Xavier BARREAU ; Leonardo RENIERI ; João Pedro FILIPE ; Pablo HARKER ; Razvan Alexandru RADU ; Thomas R. MAROTTA ; Julian SPEARS ; Takahiro OTA ; Ashkan MOWLA ; Pascal JABBOUR ; Arundhati BISWAS ; Frédéric CLARENÇON ; James E. SIEGLER ; Thanh N. NGUYEN ; Ricardo VARELA ; Amanda BAKER ; David ALTSCHUL ; Nestor R. GONZALEZ ; Markus A. MÖHLENBRUCH ; Vincent COSTALAT ; Benjamin GORY ; Christian Paul STRACKE ; Mohammad Ali AZIZ-SULTAN ; Constantin HECKER ; Hamza SHAIKH ; David S. LIEBESKIND ; Alessandro PEDICELLI ; Andrea M. ALEXANDRE ; Illario TANCREDI ; Tobias D. FAIZY ; Erwah KALSOUM ; Boris LUBICZ ; Aman B. PATEL ; Vitor Mendes PEREIRA ; Adrien GUENEGO ; Adam A. DMYTRIW ;
Journal of Stroke 2024;26(3):434-445
Background:
and Purpose The management of acute ischemic stroke (AIS) due to distal medium vessel occlusion (DMVO) remains uncertain, particularly in comparing the effectiveness of intravenous thrombolysis (IVT) plus mechanical thrombectomy (MT) versus IVT alone. This study aimed to evaluate the safety and efficacy in DMVO patients treated with either MT-IVT or IVT alone.
Methods:
This multinational study analyzed data from 37 centers across North America, Asia, and Europe. Patients with AIS due to DMVO were included, with data collected from September 2017 to July 2023. The primary outcome was functional independence, with secondary outcomes including mortality and safety measures such as types of intracerebral hemorrhage.
Results:
The study involved 1,057 patients before matching, and 640 patients post-matching. Functional outcomes at 90 days showed no significant difference between groups in achieving good functional recovery (modified Rankin Scale 0–1 and 0–2), with adjusted odds ratios (OR) of 1.21 (95% confidence interval [CI] 0.81 to 1.79; P=0.35) and 1.00 (95% CI 0.66 to 1.51; P>0.99), respectively. Mortality rates at 90 days were similar between the two groups (OR 0.75, 95% CI 0.44 to 1.29; P=0.30). The incidence of symptomatic intracerebral hemorrhage was comparable, but any type of intracranial hemorrhage was significantly higher in the MT-IVT group (OR 0.43, 95% CI 0.29 to 0.63; P<0.001).
Conclusion
The results of this study indicate that while MT-IVT and IVT alone show similar functional and mortality outcomes in DMVO patients, MT-IVT presents a higher risk of hemorrhagic complications, thus MT-IVT may not routinely offer additional benefits over IVT alone for all DMVO stroke patients. Further prospective randomized trials are needed to identify patient subgroups most likely to benefit from MT-IVT treatment in DMVO.
5.Mechanical Thrombectomy Versus Intravenous Thrombolysis in Distal Medium Vessel Acute Ischemic Stroke: A Multinational Multicenter Propensity Score-Matched Study
Hamza Adel SALIM ; Vivek YEDAVALLI ; Basel MUSMAR ; Nimer ADEEB ; Muhammed Amir ESSIBAYI ; Kareem El NAAMANI ; Nils HENNINGER ; Sri Hari SUNDARARAJAN ; Anna Luisa KÜHN ; Jane KHALIFE ; Sherief GHOZY ; Luca SCARCIA ; Benjamin Y.Q. TAN ; Benjamin PULLI ; Jeremy J. HEIT ; Robert W. REGENHARDT ; Nicole M. CANCELLIERE ; Joshua D. BERNSTOCK ; Aymeric ROUCHAUD ; Jens FIEHLER ; Sunil SHETH ; Ajit S. PURI ; Christian DYZMANN ; Marco COLASURDO ; Xavier BARREAU ; Leonardo RENIERI ; João Pedro FILIPE ; Pablo HARKER ; Razvan Alexandru RADU ; Thomas R. MAROTTA ; Julian SPEARS ; Takahiro OTA ; Ashkan MOWLA ; Pascal JABBOUR ; Arundhati BISWAS ; Frédéric CLARENÇON ; James E. SIEGLER ; Thanh N. NGUYEN ; Ricardo VARELA ; Amanda BAKER ; David ALTSCHUL ; Nestor R. GONZALEZ ; Markus A. MÖHLENBRUCH ; Vincent COSTALAT ; Benjamin GORY ; Christian Paul STRACKE ; Mohammad Ali AZIZ-SULTAN ; Constantin HECKER ; Hamza SHAIKH ; David S. LIEBESKIND ; Alessandro PEDICELLI ; Andrea M. ALEXANDRE ; Illario TANCREDI ; Tobias D. FAIZY ; Erwah KALSOUM ; Boris LUBICZ ; Aman B. PATEL ; Vitor Mendes PEREIRA ; Adrien GUENEGO ; Adam A. DMYTRIW ;
Journal of Stroke 2024;26(3):434-445
Background:
and Purpose The management of acute ischemic stroke (AIS) due to distal medium vessel occlusion (DMVO) remains uncertain, particularly in comparing the effectiveness of intravenous thrombolysis (IVT) plus mechanical thrombectomy (MT) versus IVT alone. This study aimed to evaluate the safety and efficacy in DMVO patients treated with either MT-IVT or IVT alone.
Methods:
This multinational study analyzed data from 37 centers across North America, Asia, and Europe. Patients with AIS due to DMVO were included, with data collected from September 2017 to July 2023. The primary outcome was functional independence, with secondary outcomes including mortality and safety measures such as types of intracerebral hemorrhage.
Results:
The study involved 1,057 patients before matching, and 640 patients post-matching. Functional outcomes at 90 days showed no significant difference between groups in achieving good functional recovery (modified Rankin Scale 0–1 and 0–2), with adjusted odds ratios (OR) of 1.21 (95% confidence interval [CI] 0.81 to 1.79; P=0.35) and 1.00 (95% CI 0.66 to 1.51; P>0.99), respectively. Mortality rates at 90 days were similar between the two groups (OR 0.75, 95% CI 0.44 to 1.29; P=0.30). The incidence of symptomatic intracerebral hemorrhage was comparable, but any type of intracranial hemorrhage was significantly higher in the MT-IVT group (OR 0.43, 95% CI 0.29 to 0.63; P<0.001).
Conclusion
The results of this study indicate that while MT-IVT and IVT alone show similar functional and mortality outcomes in DMVO patients, MT-IVT presents a higher risk of hemorrhagic complications, thus MT-IVT may not routinely offer additional benefits over IVT alone for all DMVO stroke patients. Further prospective randomized trials are needed to identify patient subgroups most likely to benefit from MT-IVT treatment in DMVO.