1.How are MCPIP1 and cytokines mutually regulated in cancer-related immunity?
Ruyi XU ; Yi LI ; Yang LIU ; Jianwei QU ; Wen CAO ; Enfan ZHANG ; Jingsong HE ; Zhen CAI
Protein & Cell 2020;11(12):881-893
Cytokines are secreted by various cell types and act as critical mediators in many physiological processes, including immune response and tumor progression. Cytokines production is precisely and timely regulated by multiple mechanisms at different levels, ranging from transcriptional to post-transcriptional and posttranslational processes. Monocyte chemoattractant protein-1 induced protein 1 (MCPIP1), a potent immunosuppressive protein, was first described as a transcription factor in monocytes treated with monocyte chemoattractant protein-1 (MCP-1) and subsequently found to possess intrinsic RNase and deubiquitinase activities. MCPIP1 tightly regulates cytokines expression via various functions. Furthermore, cytokines such as interleukin 1 beta (IL-1B) and MCP-1 and inflammatory cytokines inducer lipopolysaccharide (LPS) strongly induce MCPIP1 expression. Mutually regulated MCPIP1 and cytokines form a complicated network in the tumor environment. In this review, we summarize how MCPIP1 and cytokines reciprocally interact and elucidate the effect of the network formed by these components in cancer-related immunity with aim of exploring potential clinical benefits of their mutual regulation.
Chemokine CCL2/immunology*
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Humans
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Interleukin-1beta/immunology*
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Neoplasm Proteins/immunology*
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Neoplasms/pathology*
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Ribonucleases/immunology*
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Transcription Factors/immunology*
2.Role of IgG, IgA, and IgE Antibodies in Nasal Polyp Tissue: Their Relationships with Eosinophilic Infiltration and Degranulation.
Kyung Sik SUH ; Hae Sim PARK ; Dong Ho NAHM ; Yoon Keun KIM ; Young Mok LEE ; Keehyun PARK
Journal of Korean Medical Science 2002;17(3):375-380
To confirm local production of IgE, and evaluate role of immunoglobulins on eosinophil activation in nasal polyp (NP) tissue, we measured IgG, IgA, secretory IgA(sIgA), total (tIgE) and specific IgE (sIgE) to Dermatophagoides pteronyssinus(DP) by ELISA in NP tissue homogenates from 51 subjects. They were classified according to skin reactivity to DP: group I, 15 highly atopic subjects; group II, 18 weakly atopic subjects; and group III, 18 non-atopic subjects. Eosinophil cationic protein (ECP) level was measured by CAP system. Highest level of DP-sIgE was noted in group I, followed by group II and III (p<0.05). Nine (60%) of group I and 4 (22%) of group II subjects had detectable level of DP-sIgE with no significant differences in IgA, sIgA, and IgG. All of NP tissue had eosinophilic infiltration with no significant difference in activated eosinophil count or ECP level among 3 groups. A significant correlation was noted between EG2+ cell count and tIgE (r=0.55, p<0.05), and DP-sIgE level (r=0.60, p<0.05). A significant correlation was also noted between ECP and IgG (r=0.51, p<0.05) and DP-sIgE level (r=0.47, p<0.05) with no significant correlation with IgA or sIgA. These results suggest that DP-sIgE was detectable in NP tissue from weakly atopic subjects as well as highly atopic subjects. IgG and sIgE may have potential roles in eosinophil degranulation in NP tissue.
Blood Proteins/analysis
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Cell Degranulation/immunology
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Dermatophagoides pteronyssinus/immunology
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Eosinophil Granule Proteins
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Eosinophils/immunology
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Humans
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Immunoglobulin A/analysis/immunology
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Immunoglobulin E/analysis/immunology
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Immunoglobulin G/analysis/immunology
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Immunoglobulins/analysis/*immunology
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Nasal Polyps/*immunology/pathology
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*Ribonucleases
3.Hydrogen Peroxide Upregulates TNF-Related Apoptosis-Inducing Ligand (TRAIL) Expression in Human Astroglial Cells, and Augments Apoptosis of T Cells.
Yonsei Medical Journal 2006;47(4):551-557
The brain is particularly vulnerable to oxygen free radicals, and these radicals have been implicated in the pathology of several neurological disorders. In this study, the modulation of TNF-related apoptosis-inducing ligand (TRAIL) expression by oxidative stress was shown in LN215 cells, an astroglioma cell line. Hydrogen peroxide (H2O2) treatment increased TRAIL expression in LN215 cells and H2O2-induced TRAIL augmented apoptosis in Peer cells, a cell line sensitive to TRAIL- mediated cell death. Our findings suggest that the upregulation of TRAIL in astroglial cells may abrogate immune cell effector functions.
*Up-Regulation
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TNF-Related Apoptosis-Inducing Ligand/*biosynthesis
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T-Lymphocytes/*metabolism
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Ribonucleases/metabolism
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Oxidative Stress
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Immunosuppressive Agents/pharmacology
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Hydrogen Peroxide/*pharmacology
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Humans
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*Gene Expression Regulation, Neoplastic
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Cyclosporine/pharmacology
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Cell Line, Tumor
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Astrocytes/*metabolism
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*Apoptosis
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Anoxia
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Allergy and Immunology