Abstract Introduction: Occupational stress is a condition in which one or several factors in the workplace interact with workers, therefore it causes disturbance of the equilibrium both physiological and psychological matter. For a driver, occupational stress will impact on the declining performance that may threaten the safety while driving. Consequently, occupational stress becomes one of the most processes which is being related to harmful behavior to drivers that may affect the risk of accidents. This study aims to analyze the correlation between quantity and quality of sleep with occupational stress on truckload drivers. Methods: This study uses a cross-sectional method. Data instruments are utilizing a questionnaire and few additional instruments (e.g. cocoro meter, fitbit, sphygmomanometer, and oximetry) to measure the relationship between quantity and quality of sleep to occupational stress as its supporting data. The data obtained were statistically analyzed using the chi-square test and different mean test. Results: 27 respondents (60%) experiencing occupational stress at a mild level and 18 respondents (40%) experiencing occupational stress at a moderate level. Conclusion: In addition, from the results of the analysis, it was found that there is a correlation between quantity and quality of sleep with occupational stress on truckload drivers.