1.Value of serum miR-922 and miR-506 expression levels in the diagnosis and prognostic assessment of childhood acute lymphoblastic leukemia.
Yi-Yue ZHU ; Ri-Nuan WU ; Xia LI ; Xiang-Bi CHEN
Chinese Journal of Contemporary Pediatrics 2021;23(10):1021-1026
OBJECTIVES:
To study the value of serum miR-922 and miR-506 expression levels in the diagnosis and prognostic assessment of childhood acute lymphoblastic leukemia (ALL).
METHODS:
A total of 132 children with ALL (ALL group) and 80 healthy children (healthy control group) were prospectively selected in this study. Quantitative real-time polymerase chain reaction was used to measure the expression levels of serum miR-922 and miR-506 in both groups. Receiver operating characteristic (ROC) curves were plotted to analyze the diagnostic value of miR-922 and miR-506 for childhood ALL. The Kaplan-Meier method was used to plot survival curves, and multivariate COX regression models were used to analyze the risk factors for poor prognosis in children with ALL.
RESULTS:
The ALL group had significantly higher expression levels of serum miR-922 and miR-506 than the control group (
CONCLUSIONS
The expression levels of miR-922 and miR-506 are of good value in the diagnosis and prognostic assessment of childhood ALL.
Biomarkers, Tumor
;
Child
;
Humans
;
Kaplan-Meier Estimate
;
MicroRNAs/genetics*
;
Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics*
;
Prognosis
;
ROC Curve