PURPOSE: The authors used the instrument, OCT3, to evaluate the reproducibility and map the macular thickness rapidly in normal subjects METHODS: Macular thickness was measured in 120 eyes of 62 normal subjects, aged 18 to 79 years, with the macular OCT3 map. There was no history of ocular disease in any of the subjects, and routine ophthalmoscopic examination results were normal. RESULTS: The coefficient value for macular thickness was lower than 2%, indicating that OCT3 provides reliable measurements. Macular thickness of normal subjects was 193.4 +/- 14.6 micro meter in the central ring, 273.0 +/- 14.8 micro meter in the inner ring and 238.2 +/- 15.6 micro meter in the outer ring. The nasal and superior quadrants of the inner ring and the nasal quadrant of the outer ring had higher thickness measurements than another. A decrease of retinal thickness was observed in the old group. However, gender did not have a significant effect on the values. CONCLUSIONS: Macular thickness analysis with OCT3 provided a detailed map of the macular thickness. This indicates that the method may provide a sensitive detection of pathologic thickening or thinning of the retina and suggests that the macular thickness decreases with age.
Retina ; Retinaldehyde

The Naka-Rushton equation, R=R(max) I(n)/(I(n)+K(n)), has been used to describe the luminance-response function of the scotopic electroretinogram. R(max) is the asymptotic value of the b-wave amplitude as a function of stimulus luminance, K is the intensity that produces a b-wave amplitude that is one-half R(max) and n is a dimensionless contant that controls the slope of the function and represents the degree of homogeneity of retinal sensitivity. These three parameters are often used in experimental laboratories, since it can show selective changes in each parameter. The present study describes and compares the parameters of Naka-Rushton equation obtained by using ganzfeld stimuli(R(max)=363+/-32 uv, n=0.86+/-0.06, log K=-2.39+/-0.19 log cd.sec/m2) and direct flash stimuli(R(max)=354+/-28 uv, n=0.80+/-0.06, log K=-2.26+/-0.15 log cd.sec/m2) in 20 eyes of the normal pigmented rabbits respectively. The n values were significantly increased by the ganzfeld light stimuli than by the direct flash stimuli(p<0.05).
Rabbits ; Retinaldehyde

The relationship between the amount of posterior displacement of the retinal surface at the temporal disc margin and the reference height(HRef)in analyzing optic disc using Heidelberg Retina Tomograph(HRT;Heidelberg Engineering, Heidelberg, Germany)was evaluated. The displacement was measured as mean height of contour(MHC)in the temporal 40degrees C segment(20degrees C superior and 20degrees C inferior to the horizontal midline)of optic disc. HRef is a value representing the location of the standard reference plane. The accordances of HRef and stereometric parameters between right and left disc were also evaluated. MHC in the temporal 40 degrees C and nasal 40 degrees C segment, HRef, and stereometric parameters of optic disc were measured with the HRT in 244 eyes of 122 subjects. HRef was 0.376+/-0.099 mm in the right disc and 0.385+/-0.090 mm in the left disc. There was good correlation between HRef and MHC in the temporal 40degrees C segment(r=0.97, p<0.01), but poor in the nasal 40 degrees C segment(r=0.29, p<0.01). The accordances of HRef and stereometric parameters increased as the difference of MHC in the temporal 40degrees C segment between right and left disc decreased. HRef was affected by the amount of posterior displacement of the retinal surface at the temporal disc margin, which occurs in instances such as a tilted disc. We should find the method to adjust stereometric parameters to the amount of disc tilt.
Retina* ; Retinaldehyde*

Polypoidal choroidal vasculopathy (PCV) is a retinal disorder characterized by aneurismal polypoidal lesions in choroidal vasculature. PCV appears to preferentially affect pigmented individuals and is considerably high among Asians. Most reports on patterns of PCV around Asia are based on a homogenous race (e.g. Chinese, Japanese) and very few descriptions from a multiracial population like those seen in Malaysia. The present study aimed to describe the demographic features, clinical and investigative characteristics of PCV in a multiracial group at Universiti Kebangsaaan Malaysia Medical Centre (UKMMC). Ninety one eyes of 86 PCV patients, comprising of Chinese (65.1%), Malays (31.4%), Indians (2.3%) and Eurasian (1.2%) were retrospectively reviewed. All underwent complete ophthalmic examination and investigations. Mean patient age was 70.4 years with a male preponderance (59.3%), and mostly unilateral presentation (94.1%). The logMAR mean presenting visual acuity was 0.78 ± 0.64. Polypoidal vascular lesions were located generally within the macula area (86.8%), manifesting mainly as submacular hemorrhage (59.3%). Interestingly a number of eyes (43.9%) had associated drusen. Optical coherence tomography largely demonstrated exudative changes (75.9%) and almost all patients (97.7%) had loss of external limiting membrane (ELM) and IS/OS interface. On indocyanine green angiography, majority of eyes had multiple polyps (82.4%) with ‘cluster’ (58.2%) being the commonest configuration. In conclusion, although the patterns of PCV in UKMMC were mainly similar to other Asian patients, a number of our patients had associated drusen. This indicates that PCV in our population could be a variant of neovascular age related macular degeneration and not solely idiopathic in nature.
Retinaldehyde ; Choroid

A case of retinoblastoma and Coats' disease in the same eye is presented. Coexisitence of the retinoblastoma and Coats' disease is very rarely seen, though the retinoblastoma or the Coats' disease are not uncommon diseases. After the enucleatIon under the clinical diagnosis of retinoblastoma, the careful histopathological study disclosed the unusual findings of a typical Coats' disease containing predominent telangiectasis adjacent to the undifferentiated retinoblastoma cell mass. Differentiation of Coats' disease to the so-called Coats' reaction associated with a certain retinal disorders is emphasized on the histological view point.
Diagnosis ; Retinaldehyde ; Retinoblastoma* ; Telangiectasis

The term, "macular pucker" first is described the star-shaped folds and wrinkles which sometimes appear on or near the macula after surgery for retinal detachment by Maumenee. These puckers, which has been described by Jungshaffer (1966) and Tanenbaum, Schepens, Elzeneiny, and Freeman (1970), are one of the most frequent causes of visual deterioration after successful reatachment of retina, but may also appear spontaneously in eyes which has not undergone surgery. A case of macular Pucker after a successful reatachment of the retina is presented in this report.
Retina ; Retinal Detachment* ; Retinaldehyde*

A case of Coats' disease in 15 years old boy was presented with some clinical observation. This is a rare unilateral retinal disorder with hemorrhagic and exudative properties affecting otherwise healthy young boys. A brief review of literatures has also been described.
Adolescent ; Humans ; Male ; Retinaldehyde

PURPOSE: We investigated reproducibility and repeatability of average macular thickness and volume measurements in normal eyes with Cirrus HD OCT (optical coherence tomography). METHODS: Fifty normal eyes from twenty-five subjects without medical and ocular histories were included. Macular cube 512 x 128 combination scanning using the Cirrus HD OCT was performed for a total of three times on the same visit by an experienced technician. Then other two technicians performed one more macular scanning respectively. Within-results, the intraclass correlation coefficient (ICC) was calculated for each parameter studied to evaluate repeatability and reproducibility. The correlation between macular measurements and demographic variables (age, gender, and spherical equivalent) were also investigated. RESULTS: The ICCs for intraoperator reproducibility were 0.99 on the average macular thickness and 0.96 on the macular volume. And the ICCs for interoperator repeatability were found to be 0.98 and 0.96, respectively. The ICCs for measurements of nine regional retinal thickness also were higher than 0.90. The retinal thickness was correlated with age, gender and refractive error. However, neither age nor refractive error affected to reproducibility and repeatability. CONCLUSIONS: The retinal thickness and macular volume measurements using Cirrus HD OCT in healthy volunteers showed excellent reproducibility and repeatability. Therefore, Cirrus HD OCT has been recognized as an useful tool for diagnosis and mornitoring of variable maculopathies.
Eye ; Refractive Errors ; Retinaldehyde

No abstract available.
Retinal Detachment* ; Retinaldehyde*

No abstract available.
Retinal Detachment* ; Retinaldehyde*