Objectives: The aim of this review was to examine the effects of PDT in the treatment of neovascular ARMD.
PHOTOCHEMOTHERAPY ; RETINAL NEOVASCULARIZATION ; MACULAR DEGENERATION

Human ; Female ; Middle Aged ; RETINAL NEOVASCULARIZATION ; RETINAL NEOVASCULARIZATION/SURGERY ; RETINAL PERFORATIONS ; RETINAL PERFORATIONS/SURGERY ; HUMAN ; FEMALE

PURPOSE: To investigate the effect of curcumin, known to inhibit hypoxia-inducible factor-1, on retinal neovascularization in a mouse model of oxygen-induced retinopathy (OIR). METHODS: OIR was induced by exposing C57BL/6 mice on postnatal day 7 (P7) to 75% hyperoxia for 5 days, followed by 5 days in a room with normal oxygen level. Curcumin was administered intraperitoneally once a day for 5 days from P12 or intravitreally once on P13. Mice retinas on P17 were analyzed for retinal neovascularization, which was compared between curcumin-treated and control mice. RESULTS: After intraperitoneal and intravitreal administration of curcumin, qualitative assessment of retinal neovascularization of flat-mounted retina showed no significant difference compared to control retinas. Quantitative assessment of retinal neovascularization also showed no significant difference between curcumin-treated and control mice. CONCLUSIONS: Both intraperitoneal and intravitreal administration of curcumin did not reduce retinal neovascularization in an OIR mouse model. Further investigation including development of new formulations is required for the use of curcumin as an anti-angiogenic agent for retinal neovascularization.
Animals ; Curcumin* ; Hyperoxia ; Mice* ; Oxygen ; Retina ; Retinal Neovascularization ; Retinopathy of Prematurity

A Case of lncontinentia pigmenti. Incontinentia pigmenti is a hereditary disorder of abnormal skin pigmentation with associated ocular, skeletal, and central nervous system abnormalities. Ocular findings are present in up to 35% of cases, but in Korea only two cases have been reported. Recently, the authors have experienced one case of incontinentia pigmenti in a five-day old female patient who manifested both the typical dermatologic findings and ocular abnormalities in the right eye. The fundus showed markedly dilated and tortuous vessels with flat retinal neovascularization, scattered retinal hemorrhage of right macular area. Retinal cryopexy and posterior vitrectomy were performed.
Central Nervous System ; Female ; Humans ; Incontinentia Pigmenti* ; Korea ; Retinal Hemorrhage ; Retinal Neovascularization ; Retinaldehyde ; Skin Pigmentation ; Vitrectomy

The clinical evaluation was done in eight eyes of four patients with bilateral branch retinal vein occlusion. The onset of age was from 36 to 65 years, and three pa dents were women. Hypertension was the most common associated systemic disease. Retinal neovascularization was complicated in six eyes, and five eyes had vitreous hemorrhage. The vitrectomy was performed in three eyes. We believe that branch retinal vein occlusion associated with hypertension should be followed carefully in the fellow eyes.
Female ; Humans ; Hypertension ; Retinal Neovascularization ; Retinal Vein Occlusion ; Veins* ; Vitrectomy ; Vitreous Hemorrhage

The main cause of decreased visual acuity in branch retinal vein occlusion (BRVO) are macular edema and vitreous hemorrhage due to retinal neovascularization.We retrospec- tively studied the association of macular edema, neovas- cularization and vitreous hemorrhage according to the vitreoretinal relationship in 51 eyes of 51 BRVO patients. The eyes were classified as having vitreomacular attachment (VMA) or vitromacular separation (VMS) and posterior vitreous detachment (PVD) state and studied macular edema and retinal neovascularization development according to the vitreoretinal realtionship. The prevalence of VMA was 37 (72.5%) of the eyes and VMS was 14 (27.5%) eyes. VMA group had macular edema in 75.7% (28 of 37 eyes)and no macular edema was present in VMS group.Those 42 eyes who had partial or no PVD, 35.7% (15 of 42 eyes)developed retinal neovascularization and 9 eyes of complete PVD did not occur neovascularization. Although no significant relationship was found, vitreous hemorrhage developed in 21.4% (9 of 42 eyes) of only partial or no PVD group. VMA and PVD state may influence the presence of macular edema and retinal neovascularization in association with BRVO.
Humans ; Macular Edema* ; Prevalence ; Retinal Neovascularization ; Retinal Vein Occlusion* ; Retinal Vein* ; Retinaldehyde* ; Visual Acuity ; Vitreous Detachment ; Vitreous Hemorrhage

We did clinical analysis of 14 patients who had bilateral BRVO. The peak age distribution of the patients was between 60 and 69 years of age. In this 14 patients, there were 12 women and 2 men, and the most commonly associated systemic disease was hypertension(50%). In majority of patients, the interval of disease onset between two eyes was within two years. Complications developed, including maculopathy, retinal neovascularization, vitreous hemorrhage, glaucoma, and retinal detachment. Twenty one of 28 eyes(75%) had a final visual acuity of 0.4 or less. The larger the size of capillary nonperfusion was the higher was the incidence of neovasculgulation was an effective means of prevention of vitreous hemorrhage in BRVO with neovascularzation, and vitrectomy that was done in case of persistent vitreous hemorrhage improved final visual acuity. Our findings suggest that women with history of unilateral BRVO associated with hypertension in seventh, decade have high risk of occurrence in fellow eyes within two years.
Age Distribution ; Capillaries ; Female ; Glaucoma ; Humans ; Hypertension ; Incidence ; Male ; Prognosis ; Retinal Detachment ; Retinal Neovascularization ; Retinal Vein Occlusion* ; Retinal Vein* ; Retinaldehyde* ; Risk Factors* ; Visual Acuity ; Vitrectomy ; Vitreous Hemorrhage

The clinical results in 102 eyes of 97 patients with Branch Retinal Vein Occlusion(BRVO) were evaluated in aspect of distribution, associated findings, sequelae, early and final visual acuities, and the effect of argon laser photocoagulation. There were no significant differences in morbidity rate between male and female or between right and left eye. 68.6% of all BRVO were affected in superotemporal branch veins. As sequelae, cystoid macular edema in 58 cases, retinal neovascularization in 22 cases, vitreous hemorrhages in 14 cases, vitreous tractional band in 2 cases, and non-rhegmatogenous retinal detachment in 2 cases were found. Photocoagulation was performed with an argon laser at retinal neovascularization in 20 eyes, capillary non-perfusion and cystoid macular edema in 5 eyes, and retinal detachment in 2 eyes. Photocoagulation was an affective means of reducing macular edema and decreased the risk of neovascularization and vitreous hemorrhages from sites of large capillary non-perfusion and retinal neovascularization.
Argon ; Capillaries ; Female ; Humans ; Light Coagulation ; Macular Edema ; Male ; Retinal Detachment ; Retinal Neovascularization ; Retinal Vein Occlusion* ; Retinal Vein* ; Retinaldehyde* ; Traction ; Veins ; Visual Acuity ; Vitreous Hemorrhage

PURPOSE: To determine the clinical effect of radial optic neurotomy (RON) in central retinal vein occlusion (CRVO). METHODS: The retinal findings, visual acuity and complications were analyzed in patients who had undergone RON for the treatment of CRVO and were followed up 10 months or more after surgery. RESULTS: Of all 16 patients (16 eyes), the mean age was 55 years and the follow-up period was 14 months. Preoperative anterior segment and retinal neovascularization was observed in each three eyes. All eyes showed improvement in the retinal findings within two weeks after RON. The postoperative complications included vitreous hemorrhage in 1 eye, chorioretinal collateral circulation in 1 eye, neovascular glaucoma in 1 eye, vitreous hemorrhage and neovascular glaucoma in 1 eye. The visual acuity was counting fingers or less in 8 eyes preoperatively and in 2 eyes finally, and was less than 0.1 in 13 eyes preoperatively and in 10 eyes finally. The mean visual improvement in the 3.8 lines was in 11 eyes and a loss of 2.5 lines in 2 eyes. The maximum velocity of the blood flow of CRV improved with 1.95 +/- 0.93 cm/sec on the average in the 7 eyes examined by color doppler. CONCLUSIONS: RON appears to be safe and effective for improving the retinal findings, visual acuity and blood flow of CRV in CRVO. However, the visual recovery is limited.
Collateral Circulation ; Fingers ; Follow-Up Studies ; Glaucoma, Neovascular ; Humans ; Postoperative Complications ; Retinal Neovascularization ; Retinal Vein* ; Retinaldehyde ; Visual Acuity ; Vitreous Hemorrhage

The clinical evaluation was done in eighteen eyes of nine patients with bilateral BRVO in aspects of onset, visual acuity, interval between onset of one eye and the other, sex ratio, associated systemic diseases, location of the affected vein, the effect of macular edema on visual acuity and ocular complications. The onset of age was from fifty one to sixty eight years. Eight patients were women, and one patient was man. Hypertension was the most common associated systemic disease. Ten eyes (55.5%) of bilateral BRVO were affected the superior temporal branch vein, the sites of occlusion were not more than two disc diameters from the optic disc in fifteen eyes (83.3%). The complications of seevere visual loss had macular edema, macular capillary nonperfusion, retinal neovascularization and vitreous hemorrhage. Among of six numbers who could be followed up more than one year, and visual acuity of five eyes with macula edema were decreased than five other eyes developed one year or later. Eyes that were more than five disc diameters of capillary nonperfusion, as visualized with fluorescence angiography were thirteen (72.2%). Of these eyes, six (46.1 %) eyes occured retinal neovascularization, five of those had macular capillary nonperfusion. four of those were 0.1 in final vision. Three of four eyes with vitreous hemorrhage were very slowly improved in visual acuity, but another was decreasing in visual acuity due to other ocular complications We thought that woman with history of BRVO due to hypertension in sixth and seventh decades should be followed up the other eye for three years.
Capillaries ; Edema ; Female ; Fluorescein Angiography ; Humans ; Hypertension ; Macular Edema ; Retinal Neovascularization ; Retinal Vein Occlusion* ; Retinal Vein* ; Retinaldehyde* ; Sex Ratio ; Veins ; Visual Acuity ; Vitreous Hemorrhage