The Acute Retinal Necrosis(A.R.N.) syndrome is characterized by necrotizing retinitis, vitritis, and retinal vasculitis. We experienced 5 eyes of 4 cases with Acute Retinal Necrosis in otherwise healthy patients. In this study, 3 of 4 cases(75%) were male, retinal detachment developed in 3 eyes(60%), and 3 of 4 cases(75%) were unilateral. 4 of 5 eyes(80%) had a final visual acuity of less than 0.1.
Humans ; Male ; Retinal Detachment ; Retinal Necrosis Syndrome, Acute* ; Retinal Vasculitis ; Retinaldehyde ; Retinitis ; Visual Acuity

The Acute Retinal Necrosis(ARN) is characterized by necrotizing retinitis, uveit is and retinal vasculitis occurring in otherwise healthy patients. The cause of this disorder is thought to be herpes group virus. The ARN typically presents with the incidious onset of diffuse uveitis, followed by acute retinal whitening, vasculitis, leading to severe destruction of the retinal architecture, frequent retinal detachment and consequent loss of visual function. We experienced 4 cases of ARN in otherwise healthy patients. We treated 4 cases of ARN with intravenous acyclovir(1500mg/M2/day) and oral prednisone. Among 4 cases, one case retained relatively good visual acuity(20/70), 3 cases remained light perception and 2 cases developed retinal detachment. No patient developed new retinal lesion in the fellow eye and there was no evident ocular or systemic side effect from this tyerapy. Intravenous acyclovir and oral prednisone for the treatment of early stage of ARN is not dramatic in effectiveness but seemed to be the treatment of choice at present time.
Acyclovir* ; Humans ; Prednisone ; Retinal Detachment ; Retinal Necrosis Syndrome, Acute* ; Retinal Vasculitis ; Retinaldehyde ; Retinitis ; Uveitis ; Vasculitis

The acute retinal necrosis is characterized by necrotizing retinitis, vitritis, and retinal vasculitis occurring in otherwise healthy patients. It develops into retinal necrosis and detachment. The clinical course of ARN is rapidly progressive despite therapeutic efforts. We experienced 6 eyes of 5 cases with ARN. In this study, the distribution of patients was 3 males and 2 females and they were from 23 to 53 years old in age, average 39.4 years. The duration of observation was from 3 days to 24 months and we observed retinal detachment in 2 cases(40%) that developed 2 weeks and 4 weeks after onset in each cases. One case involved both eyes, and the other, in one eye. Four of 6 eyes(65%) had a final visual acuity of less than 0.1.
Female ; Humans ; Male ; Middle Aged ; Necrosis ; Retinal Detachment ; Retinal Necrosis Syndrome, Acute* ; Retinal Vasculitis ; Retinaldehyde ; Retinitis ; Visual Acuity

Acute multifocal hemorrhagic retinal vasculitis is a disorder of abrupt onset, of unilateral or bilateral visual loss associated with mild anterior uveitis multifocal retinal vasculitis, retinal hemorrhage, retinal capiHary nonperfusion,papillitis, vitritis. After the onset of the disease, recurrent episode of intraocular inflammation, vasculitis, and visual loss ate commonly seen associated with the late complications of secondary vitreous hemorrhage, neovascular glaucoma, and epiretinal membrane formation. In 1988, Blumenkranz and associates were the first to report 7 cases of this disease in America. The mode of presentation, associated symptoms, and fundus findings are suggestive of herpes class virus infection, although the etiology remains unknown. We experienced a case of acute multifocal hemorrhagic retinal vasculitis associated with multifocal retinal vasculitis, retinal hemorrhage and neovascu lar complications.
Americas ; Epiretinal Membrane ; Glaucoma, Neovascular ; Inflammation ; Retinal Hemorrhage ; Retinal Necrosis Syndrome, Acute ; Retinal Vasculitis* ; Retinaldehyde* ; Uveitis, Anterior ; Vasculitis ; Vitreous Hemorrhage

PURPOSE: To report a case of acyclovir-induced acute renal failure (ARF) suspected as acute retinal necrosis syndrome. CASE SUMMARY: The authors report a 55-year-old male patient who presented with left eye visual disturbance due to suspected acute retinal necrosis syndrome. Non-oliguric ARF developed after the infusion of intravenous acyclovir (850 mg every 8 hours). The patient did not show any uremic symptoms or signs. The crystal was not discovered in the urine. After stopping the acyclovir infusion and hydration, acyclovir-induced ARF was reversed. CONCLUSIONS: Although possessing critical nephrotoxicity, acyclovir is a useful antiviral drug. Therefore, when using acyclovir, the importance of hydration and preventing acyclovir-induced ARF should be considered.
Acute Kidney Injury ; Acyclovir ; Eye ; Humans ; Male ; Middle Aged ; Retinal Necrosis Syndrome, Acute

PURPOSE: We report the results in two patients received prophylactic surgery to prevent retinal detachment in the severe acute retinal necrosis. CASE SUMMARY: Two patients in whom the presumptive diagnosis of the severe acute retinal necrosis were concomitantly treated with antiviral agents, systemic steroids and anti platelet therapy. We performed vitrectomy and silicone oil tamponade as the prophylactic surgical procedure for retinal detachments. The retinas remained attached in all patients over a follow up periods. CONCLUSIONS: Retinal detachment secondary to acute retinal necrosis has a complex nature and usually results in severe visual loss. A combination of vitrectomy and silicone oil tamponade may be effective prophylaxes against retinal detachment in acute retinal necrosis.
Antiviral Agents ; Blood Platelets ; Follow-Up Studies ; Humans ; Retina ; Retinal Detachment ; Retinal Necrosis Syndrome, Acute ; Retinaldehyde ; Silicone Oils ; Steroids ; Vitrectomy

The acute retinal necrosis syndrome is a rare disease and result in poor visual prognosis in the late stage. The acute retinal necrosis syndrome occurs commonly in otherwise healthy individuals but we treated a patient with the acute retinal necrosis syndrome who had been medicated with immunosuppressive agents after kidney transplantaion.
Humans ; Immunosuppressive Agents ; Kidney Transplantation ; Kidney* ; Prognosis ; Rare Diseases ; Retinal Necrosis Syndrome, Acute*

PURPOSE: To report one case of bilateral acute retinal necrosis (ARN) syndrome in the patient with acquired immunodeficiency syndrome (AIDS). METHODS: Bilateral retinal necrosis, occlusive vasculitis, vitreous opacity and inflammatory reaction in anterior chamber were noted in a 48-years old man with AIDS. RESULTS: The patient was diagnosed as bilateral ARN, but did not respond to intravenous acyclovir therapy. However, the patient was successfully treated with intravenous ganciclovir at a dosage of 5 mg/kg/day, which resulted in resolution of retinal lesion and improvement of visual acuity without complications such as retinal detachment. CONCLUSIONS: CMV retinitis, progressive outer retinal necrosis, ocular syphilis should be considered in the differential diagnosis of ARN syndrome in the AIDS patients and alternative treatment with ganciclovir should be considered promptly when the patient do not respond to acyclovir therapy.
Acquired Immunodeficiency Syndrome* ; Acyclovir ; Anterior Chamber ; Diagnosis, Differential ; Ganciclovir ; Humans ; Middle Aged ; Necrosis ; Retinal Detachment ; Retinal Necrosis Syndrome, Acute* ; Retinaldehyde ; Retinitis ; Syphilis ; Vasculitis ; Visual Acuity

PURPOSE: Retinal detachment (RD) complicated in acute retinal necrosis (ARN) is difficult to be treated and a main cause of blindness. The factors associated with RD in ARN were investigated. METHODS: Patients with ARN who were diagnosed and treated from Jan, 2008 to Dec, 2012 were reviewed retrospectively. The eyes were classified into the group I without RD, and the group II with RD. Early vitrectomy, history of ARN in the other eye, extent of necrosis, symptom duration and intravitreal injection of anti-viral drug were evaluated. RESULTS: Of 22 eyes of 20 patients, 11 eyes were included in each group. Symptom duration of 8.0 days in the group I was shorter than 15.8 days in the group II (p = 0.005). There were no macular involvement at initial exam in the group I and 5 eyes (45%) in the group II (p = 0.017). Five eyes (45%) in the group I and 0 eye (0%) in the group II had history of ARN in the other eye (p = 0.017). Six eyes (55%) in the group I and 1 eye (9%) in the group II underwent early vitrectomy (p = 0.031). Age, baseline visual acuity, and intravitreal injection of antiviral agent were not related to RD (p = 0.294-0.699). CONCLUSIONS: Broader necrosis and longer symptoms duration were related to occurrence of RD. Correlation of Lower risk of RD with ARN history in the other eye would result from earlier diagnosis and treatment. Early vitrectomy seems to be effective to prevent RD in ARN.
Blindness ; Diagnosis ; History ; Humans ; Intravitreal Injections ; Necrosis ; Retinal Detachment* ; Retinal Necrosis Syndrome, Acute* ; Retinaldehyde* ; Retrospective Studies ; Risk Factors* ; Visual Acuity ; Vitrectomy

PURPOSE:To report the use of intravitreal antiviral injections as adjunctive therapy in the managementof two immunocompetent patients with acute retinal necrosis. CASE SUMMARY: We performed two or three intravitreal injections of gancyclovir (2,000 microg/0.05 ml) on two patients (two eyes) with acute retinal necrosis resistant to intravenous acyclovir therapy (1,500 mg/m2/day). Both patients received intravitreal antiviral injections for the treatment of retinitis that progressed despite standard intravenous acyclovir therapy. The retinitis resolved, and visual acuity improved after 18 months of follow-up in both cases. CONCLUSIONS: Intravitreal antiviral injections may be a safe and efficacious adjunctive therapy in the management of patients with acute retinal necrosis resistant to intravenous acyclovir therapy.
Acyclovir ; Antiviral Agents ; Follow-Up Studies ; Ganciclovir ; Humans ; Intravitreal Injections ; Retinal Necrosis Syndrome, Acute ; Retinitis ; Visual Acuity